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Table of Contents

February 2007; 56 (2)

Obesity Studies

    • Stephen B. Wheatcroft,
    • Mark T. Kearney,
    • Ajay M. Shah,
    • Vivienne A. Ezzat,
    • John R. Miell,
    • Michael Modo,
    • Stephen C.R. Williams,
    • Will P. Cawthorn,
    • Gema Medina-Gomez,
    • Antonio Vidal-Puig,
    • Jaswinder K. Sethi,
    • and Paul A. Crossey

    IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance

    Diabetes February 2007 56:285-294; doi:10.2337/db06-0436
    • Wendy S. Wright,
    • Kenneth A. Longo,
    • Vernon W. Dolinsky,
    • Isabelle Gerin,
    • Sona Kang,
    • Christina N. Bennett,
    • Shian-Huey Chiang,
    • Tyler C. Prestwich,
    • Catherine Gress,
    • Charles F. Burant,
    • Vedrana S. Susulic,
    • and Ormond A. MacDougald

    Wnt10b Inhibits Obesity in ob/ob and Agouti Mice

    Diabetes February 2007 56:295-303; doi:10.2337/db06-1339

Islet Studies

    • Sakeneh Zraika,
    • Rebecca L. Hull,
    • Jayalakshmi Udayasankar,
    • Anne Clark,
    • Kristina M. Utzschneider,
    • Jenny Tong,
    • Fernando Gerchman,
    • and Steven E. Kahn

    Identification of the Amyloid-Degrading Enzyme Neprilysin in Mouse Islets and Potential Role in Islet Amyloidogenesis

    Diabetes February 2007 56:304-310; doi:10.2337/db06-0430
    • Pavlos Pissios,
    • Umut Ozcan,
    • Efi Kokkotou,
    • Terumasa Okada,
    • Chong Wee Liew,
    • Siming Liu,
    • Jennifer N. Peters,
    • Gabriella Dahlgren,
    • Jason Karamchandani,
    • Yogish C. Kudva,
    • Amarnath J. Kurpad,
    • Robert T. Kennedy,
    • Eleftheria Maratos-Flier,
    • and Rohit N. Kulkarni

    Melanin Concentrating Hormone Is a Novel Regulator of Islet Function and Growth

    Diabetes February 2007 56:311-319; doi:10.2337/db06-0708
    • Sarah J. Bailey,
    • Magalie A. Ravier,
    • and Guy A. Rutter

    Glucose-Dependent Regulation of γ-Aminobutyric Acid (GABAA) Receptor Expression in Mouse Pancreatic Islet α-Cells

    Diabetes February 2007 56:320-327; doi:10.2337/db06-0712
    • Ricard Masia,
    • Joseph C. Koster,
    • Stefano Tumini,
    • Francesco Chiarelli,
    • Carlo Colombo,
    • Colin G. Nichols,
    • and Fabrizio Barbetti

    An ATP-Binding Mutation (G334D) in KCNJ11 Is Associated With a Sulfonylurea-Insensitive Form of Developmental Delay, Epilepsy, and Neonatal Diabetes

    Diabetes February 2007 56:328-336; doi:10.2337/db06-1275
    • Keun-Gyu Park,
    • Kyeong-Min Lee,
    • Hye-Young Seo,
    • Ji-Ho Suh,
    • Hye-Soon Kim,
    • Li Wang,
    • Kyu-Chang Won,
    • Hyoung-Woo Lee,
    • Joong-Yeol Park,
    • Ki-Up Lee,
    • Jung-Guk Kim,
    • Bo-Wan Kim,
    • Hueng-Sik Choi,
    • and In-Kyu Lee

    Glucotoxicity in the INS-1 Rat Insulinoma Cell Line Is Mediated by the Orphan Nuclear Receptor Small Heterodimer Partner

    Diabetes February 2007 56:431-437; doi:10.2337/db06-0753
    • Jocelyn de Heer and
    • Jens J. Holst

    Sulfonylurea Compounds Uncouple the Glucose Dependence of the Insulinotropic Effect of Glucagon-Like Peptide 1

    Diabetes February 2007 56:438-443; doi:10.2337/db06-0738

Complications

    • Ling Zheng,
    • Scott J. Howell,
    • Denise A. Hatala,
    • Kun Huang,
    • and Timothy S. Kern

    Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy

    Diabetes February 2007 56:337-345; doi:10.2337/db06-0789
    • Matthias Meier,
    • Joon-Keun Park,
    • Daniel Overheu,
    • Torsten Kirsch,
    • Carsten Lindschau,
    • Faikah Gueler,
    • Michael Leitges,
    • Jan Menne,
    • and Hermann Haller

    Deletion of Protein Kinase C-β Isoform In Vivo Reduces Renal Hypertrophy but Not Albuminuria in the Streptozotocin-Induced Diabetic Mouse Model

    Diabetes February 2007 56:346-354; doi:10.2337/db06-0891
    • Eric P. Davidson,
    • Travis L. Kleinschmidt,
    • Christine L. Oltman,
    • Donald D. Lund,
    • and Mark A. Yorek

    Treatment of Streptozotocin-Induced Diabetic Rats With AVE7688, a Vasopeptidase Inhibitor: Effect on Vascular and Neural Disease

    Diabetes February 2007 56:355-362; doi:10.2337/db06-1180
    • Hitomi Kataoka Usui,
    • Kenichi Shikata,
    • Motofumi Sasaki,
    • Shinichi Okada,
    • Mitsuhiro Matsuda,
    • Yasushi Shikata,
    • Daisuke Ogawa,
    • Yuichi Kido,
    • Ryo Nagase,
    • Kosuke Yozai,
    • Sakiko Ohga,
    • Atsuhito Tone,
    • Jun Wada,
    • Motohiro Takeya,
    • Seikoh Horiuchi,
    • Tatsuhiko Kodama,
    • and Hirofumi Makino

    Macrophage Scavenger Receptor-A–Deficient Mice Are Resistant Against Diabetic Nephropathy Through Amelioration of Microinflammation

    Diabetes February 2007 56:363-372; doi:10.2337/db06-0359
    • Timothy S. Kern,
    • Casey M. Miller,
    • Yunpeng Du,
    • Ling Zheng,
    • Susanne Mohr,
    • Sherry L. Ball,
    • M. Kim,
    • Jeffrey A. Jamison,
    • and David P. Bingaman

    Topical Administration of Nepafenac Inhibits Diabetes-Induced Retinal Microvascular Disease and Underlying Abnormalities of Retinal Metabolism and Physiology

    Diabetes February 2007 56:373-379; doi:10.2337/db05-1621
    • Leileata M. Russo,
    • Elisabetta del Re,
    • Dennis Brown,
    • and Herbert Y. Lin

    Evidence for a Role of Transforming Growth Factor (TGF)-β1 in the Induction of Postglomerular Albuminuria in Diabetic Nephropathy: Amelioration by Soluble TGF-β Type II Receptor

    Diabetes February 2007 56:380-388; doi:10.2337/db06-1018
    • Anna Michno,
    • Hanna Bielarczyk,
    • Tadeusz Pawełczyk,
    • Agnieszka Jankowska-Kulawy,
    • Joanna Klimaszewska,
    • and Andrzej Szutowicz

    Alterations of Adenine Nucleotide Metabolism and Function of Blood Platelets in Patients With Diabetes

    Diabetes February 2007 56:462-467; doi:10.2337/db06-0390
    • Mette M. Madsen,
    • Hanne M. Søndergaard,
    • Morten Bøttcher,
    • Niels H. Buus,
    • Ole Schmitz,
    • Hans E. Bøtker,
    • and Torsten T. Nielsen

    Impact of Type 2 Diabetes on Nitric Oxide and Adrenergic Modulation of Myocardial Perfusion

    Diabetes February 2007 56:468-475; doi:10.2337/db06-0635
    • Meenalakshmi M. Mariappan,
    • Denis Feliers,
    • Srinivas Mummidi,
    • Goutam Ghosh Choudhury,
    • and Balakuntalam S. Kasinath

    High Glucose, High Insulin, and Their Combination Rapidly Induce Laminin-β1 Synthesis by Regulation of mRNA Translation in Renal Epithelial Cells

    Diabetes February 2007 56:476-485; doi:10.2337/db05-1334

Brief Reports

    • Donna M. Lehman,
    • Kelly J. Hunt,
    • Robin J. Leach,
    • Jeanette Hamlington,
    • Rector Arya,
    • Hanna E. Abboud,
    • Ravindranath Duggirala,
    • John Blangero,
    • Harald H.H. Göring,
    • and Michael P. Stern

    Haplotypes of Transcription Factor 7–Like 2 (TCF7L2) Gene and Its Upstream Region Are Associated With Type 2 Diabetes and Age of Onset in Mexican Americans

    Diabetes February 2007 56:389-393; doi:10.2337/db06-0860
    • Donna M. Lehman,
    • Dawn K. Richardson,
    • Chris P. Jenkinson,
    • Kelly J. Hunt,
    • Thomas D. Dyer,
    • Robin J. Leach,
    • Rector Arya,
    • Hanna E. Abboud,
    • John Blangero,
    • Ravindranath Duggirala,
    • and Michael P. Stern

    P2 Promoter Variants of the Hepatocyte Nuclear Factor 4α Gene Are Associated With Type 2 Diabetes in Mexican Americans

    Diabetes February 2007 56:513-517; doi:10.2337/db06-0881
    • Masashi Tanaka,
    • Noriyuki Fuku,
    • Yutaka Nishigaki,
    • Hitoshi Matsuo,
    • Tomonori Segawa,
    • Sachiro Watanabe,
    • Kimihiko Kato,
    • Kiyoshi Yoko,
    • Masafumi Ito,
    • Yoshinori Nozawa,
    • and Yoshiji Yamada

    Women With Mitochondrial Haplogroup N9a Are Protected Against Metabolic Syndrome

    Diabetes February 2007 56:518-521; doi:10.2337/db06-1105
    • Claude Chelala,
    • Sabine Duchatelet,
    • Marie-Line Joffret,
    • Regine Bergholdt,
    • Danièle Dubois-Laforgue,
    • Pegah Ghandil,
    • Flemming Pociot,
    • Sophie Caillat-Zucman,
    • José Timsit,
    • and Cécile Julier

    PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits

    Diabetes February 2007 56:522-526; doi:10.2337/db06-0942
    • Robert H. Nelson,
    • Abhiram Prasad,
    • Amir Lerman,
    • and John M. Miles

    Myocardial Uptake of Circulating Triglycerides in Nondiabetic Patients With Heart Disease

    Diabetes February 2007 56:527-530; doi:10.2337/db06-1552
    • Jose C. Florez,
    • Kathleen A. Jablonski,
    • Steven E. Kahn,
    • Paul W. Franks,
    • Dana Dabelea,
    • Richard F. Hamman,
    • William C. Knowler,
    • David M. Nathan,
    • and David Altshuler

    Type 2 Diabetes–Associated Missense Polymorphisms KCNJ11 E23K and ABCC8 A1369S Influence Progression to Diabetes and Response to Interventions in the Diabetes Prevention Program

    Diabetes February 2007 56:531-536; doi:10.2337/db06-0966
    • Ilija P. Kovac,
    • Richard J. Havlik,
    • Daniel Foley,
    • Rita Peila,
    • Dena Hernandez,
    • Fabienne Wavrant-De Vrièze,
    • Andrew Singleton,
    • Josephine Egan,
    • Dennis Taub,
    • Beatriz Rodriguez,
    • Kamal Masaki,
    • J. David Curb,
    • Wilfred Y. Fujimoto,
    • and Alexander F. Wilson

    Linkage and Association Analyses of Type 2 Diabetes/Impaired Glucose Metabolism and Adiponectin Serum Levels in Japanese Americans From Hawaii

    Diabetes February 2007 56:537-540; doi:10.2337/db06-0443

Signal Transduction

    • Lellean JeBailey,
    • Oshrit Wanono,
    • Wenyan Niu,
    • Jessica Roessler,
    • Assaf Rudich,
    • and Amira Klip

    Ceramide- and Oxidant-Induced Insulin Resistance Involve Loss of Insulin-Dependent Rac-Activation and Actin Remodeling in Muscle Cells

    Diabetes February 2007 56:394-403; doi:10.2337/db06-0823
    • Iria Nieto-Vazquez,
    • Sonia Fernández-Veledo,
    • Cristina de Alvaro,
    • Cristina M. Rondinone,
    • Angela M. Valverde,
    • and Margarita Lorenzo

    Protein–Tyrosine Phosphatase 1B–Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-α–Induced Insulin Resistance

    Diabetes February 2007 56:404-413; doi:10.2337/db06-0989
    • Farah S.L. Thong,
    • Philip J. Bilan,
    • and Amira Klip

    The Rab GTPase-Activating Protein AS160 Integrates Akt, Protein Kinase C, and AMP-Activated Protein Kinase Signals Regulating GLUT4 Traffic

    Diabetes February 2007 56:414-423; doi:10.2337/db06-0900

Immunology and Transplantation

    • Yi-Guang Chen,
    • Pablo A. Silveira,
    • Melissa A. Osborne,
    • Harold D. Chapman,
    • and David V. Serreze

    Cellular Expression Requirements for Inhibition of Type 1 Diabetes by a Dominantly Protective Major Histocompatibility Complex Haplotype

    Diabetes February 2007 56:424-430; doi:10.2337/db06-1303

Pathophysiology

    • Helge Ræder,
    • Ingfrid S. Haldorsen,
    • Lars Ersland,
    • Renate Grüner,
    • Torfinn Taxt,
    • Oddmund Søvik,
    • Anders Molven,
    • and Pål R. Njølstad

    Pancreatic Lipomatosis Is a Structural Marker in Nondiabetic Children With Mutations in Carboxyl-Ester Lipase

    Diabetes February 2007 56:444-449; doi:10.2337/db06-0859
    • Bolin Qin,
    • Wei Qiu,
    • Rita Kohen Avramoglu,
    • and Khosrow Adeli

    Tumor Necrosis Factor-α Induces Intestinal Insulin Resistance and Stimulates the Overproduction of Intestinal Apolipoprotein B48-Containing Lipoproteins

    Diabetes February 2007 56:450-461; doi:10.2337/db06-0518

Pharmacology and Therapeutics

    • Silvia García-Vicente,
    • Francesc Yraola,
    • Luc Marti,
    • Elena González-Muñoz,
    • María José García-Barrado,
    • Carles Cantó,
    • Anna Abella,
    • Sandy Bour,
    • Rafael Artuch,
    • Cristina Sierra,
    • Nuria Brandi,
    • Christian Carpéné,
    • Julio Moratinos,
    • Marta Camps,
    • Manuel Palacín,
    • Xavier Testar,
    • Anna Gumà,
    • Fernando Albericio,
    • Miriam Royo,
    • Alec Mian,
    • and Antonio Zorzano

    Oral Insulin-Mimetic Compounds That Act Independently of Insulin

    Diabetes February 2007 56:486-493; doi:10.2337/db06-0269

Genetics

    • Aline Meirhaeghe,
    • Colin A.G. Boreham,
    • Liam J. Murray,
    • Florence Richard,
    • George Davey Smith,
    • Ian S. Young,
    • and Philippe Amouyel

    A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth

    Diabetes February 2007 56:494-498; doi:10.2337/db06-0915
    • Watip Boonyasrisawat,
    • Delphine Eberle,
    • Simonetta Bacci,
    • Yuan-Yuan Zhang,
    • David Nolan,
    • Ernest V. Gervino,
    • Michael T. Johnstone,
    • Vincenzo Trischitta,
    • Steven E. Shoelson,
    • and Alessandro Doria

    Tag Polymorphisms at the A20 (TNFAIP3) Locus Are Associated With Lower Gene Expression and Increased Risk of Coronary Artery Disease in Type 2 Diabetes

    Diabetes February 2007 56:499-505; doi:10.2337/db06-0946
    • Norihide Yokoi,
    • Chihiro Hayashi,
    • Yuuka Fujiwara,
    • He-Yao Wang,
    • and Susumu Seino

    Genetic Reconstitution of Autoimmune Type 1 Diabetes With Two Major Susceptibility Genes in the Rat

    Diabetes February 2007 56:506-512; doi:10.2337/db06-1027

Perspectives in Diabetes

    • Sif G. Rønn,
    • Nils Billestrup,
    • and Thomas Mandrup-Poulsen

    Diabetes and Suppressors of Cytokine Signaling Proteins

    Diabetes February 2007 56:541-548; doi:10.2337/db06-1068

Erratum

  • Errata

    Diabetes February 2007 56:549; doi:10.2337/db07-er02
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This Issue

February 2007; 56 (2)
  1. Obesity Studies
  2. Islet Studies
  3. Complications
  4. Brief Reports
  5. Signal Transduction
  6. Immunology and Transplantation
  7. Pathophysiology
  8. Pharmacology and Therapeutics
  9. Genetics
  10. Perspectives in Diabetes
  11. Erratum

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