Women With Mitochondrial Haplogroup N9a Are Protected Against Metabolic Syndrome
- Masashi Tanaka1,
- Noriyuki Fuku1,
- Yutaka Nishigaki1,
- Hitoshi Matsuo2,
- Tomonori Segawa2,
- Sachiro Watanabe2,
- Kimihiko Kato3,
- Kiyoshi Yoko3,
- Masafumi Ito4,
- Yoshinori Nozawa4 and
- Yoshiji Yamada5
- 1Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
- 2Department of Cardiology, Gifu Prefectural Gifu Hospital, Gifu, Japan
- 3Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
- 4Gifu International Institute of Biotechnology, Kakamigahara, Japan
- 5Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
- Address correspondence and reprint requests to Masashi Tanaka, MD, PhD, Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. E-mail: mtanaka{at}tmig.or.jp
Abstract
To identify mitochondrial haplogroups that confer resistance against or susceptibility to metabolic syndrome, we performed a large-scale association study on 1,337 unrelated Japanese individuals, including 871 subjects with metabolic syndrome and 466 control subjects. Metabolic syndrome was diagnosed according to modified National Cholesterol Education Program Adult Treatment Panel III guidelines, using the cutoff point for obesity as a BMI of ≥25 kg/m2 instead of waist circumference. The genotypes for 25 polymorphisms in the coding region of the mitochondrial genome were determined, and the haplotypes were classified into 10 major haplogroups, i.e., F, B, A, N9a, M7a, M7b, G1, G2, D5, and D4. Multivariate logistic regression analysis revealed that the haplogroup N9a was significantly associated with resistance against metabolic syndrome in women with an odds ratio (OR) of 0.21 (95% CI 0.07–0.58, P = 0.0042). Women with haplogroups G1 and D5 tended to be resistant against metabolic syndrome with an OR of 0.22 (0.06–0.68, P = 0.0129) for G1 and with an OR of 0.32 (0.10–0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women.
Footnotes
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Additional information for this article can be found in an online appendix at http://dx.doi.org/10.2337/db06-1105.
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Accepted November 3, 2006.
- Received August 8, 2006.
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