Table of Contents

• Romain Harmancey,
• Jean-Michel Senard,
• Philippe Rouet,
• Atul Pathak,
• and Fatima Smih

Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin

• Kimberly R. Coenen,
• Marnie L. Gruen,
• Alan Chait,
• and Alyssa H. Hasty

Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue

• Fiona Moloney,
• Sinead Toomey,
• Enda Noone,
• Anne Nugent,
• Bernard Allan,
• Christine E. Loscher,
• and Helen M. Roche

Antidiabetic Effects of cis-9, trans-11–Conjugated Linoleic Acid May Be Mediated via Anti-Inflammatory Effects in White Adipose Tissue

• Mikael Bjursell,
• Andrea Ahnmark,
• Mohammad Bohlooly-Y,
• Lena William-Olsson,
• Magdalena Rhedin,
• Xiao-Rong Peng,
• Karolina Ploj,
• Anna-Karin Gerdin,
• Gunnel Arnerup,
• Anders Elmgren,
• Anna-Lena Berg,
• Jan Oscarsson,
• and Daniel Lindén

Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism

• Roger Lehmann,
• Richard A. Zuellig,
• Patrick Kugelmeier,
• Philipp B. Baenninger,
• Wolfgang Moritz,
• Aurel Perren,
• Pierre-Alain Clavien,
• Markus Weber,
• and Giatgen A. Spinas

Superiority of Small Islets in Human Islet Transplantation

• Todd Brusko,
• Clive Wasserfall,
• Kieran McGrail,
• Richard Schatz,
• Hilla Lee Viener,
• Desmond Schatz,
• Michael Haller,
• Jennifer Rockell,
• Peter Gottlieb,
• Michael Clare-Salzler,
• and Mark Atkinson

No Alterations in the Frequency of FOXP3⁺ Regulatory T-Cells in Type 1 Diabetes

• Roberto Mallone,
• Emanuela Martinuzzi,
• Philippe Blancou,
• Giulia Novelli,
• Georgia Afonso,
• Manuel Dolz,
• Graziella Bruno,
• Lucy Chaillous,
• Lucienne Chatenoud,
• Jean-Marie Bach,
• and Peter van Endert

CD8⁺ T-Cell Responses Identify β-Cell Autoimmunity in Human Type 1 Diabetes

• Craig Meagher,
• Guillermo Arreaza,
• Andrew Peters,
• Craig A. Strathdee,
• Philippe A. Gilbert,
• Qing-Sheng Mi,
• Pere Santamaria,
• Gregory A. Dekaban,
• and Terry L. Delovitch

CCL4 Protects From Type 1 Diabetes by Altering Islet β-Cell–Targeted Inflammatory Responses

• Claudia Miele,
• Gregory Alexander Raciti,
• Angela Cassese,
• Chiara Romano,
• Ferdinando Giacco,
• Francesco Oriente,
• Flora Paturzo,
• Francesco Andreozzi,
• Assunta Zabatta,
• Giancarlo Troncone,
• Fatima Bosch,
• Anna Pujol,
• Hervé Chneiweiss,
• Pietro Formisano,
• and Francesco Beguinot

PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic β-Cells

• Jenny M. Phillips,
• Lorraine O’Reilly,
• Chris Bland,
• Alan K. Foulis,
• and Anne Cooke

Patients With Chronic Pancreatitis Have Islet Progenitor Cells in Their Ducts, but Reversal of Overt Diabetes in NOD Mice by Anti-CD3 Shows No Evidence for Islet Regeneration

• Sophia Thore,
• Anne Wuttke,
• and Anders Tengholm

Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca²⁺ and the ATP-to-ADP Ratio

• Carmella Evans-Molina,
• James C. Garmey,
• Robert Ketchum,
• Kenneth L. Brayman,
• Shaoping Deng,
• and Raghavendra G. Mirmira

Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets

• Dirk Westermann,
• Susanne Rutschow,
• Sebastian Jäger,
• Anne Linderer,
• Stefan Anker,
• Alexander Riad,
• Thomas Unger,
• Heinz-Peter Schultheiss,
• Matthias Pauschinger,
• and Carsten Tschöpe

Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy: The Role of Angiotensin Type 1 Receptor Antagonism

• James L. Figarola,
• Narkunaraja Shanmugam,
• Rama Natarajan,
• and Samuel Rahbar

Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes

• Yongjun Li,
• Surovi Hazarika,
• Donghua Xie,
• Anne M. Pippen,
• Christopher D. Kontos,
• and Brian H. Annex

In Mice With Type 2 Diabetes, a Vascular Endothelial Growth Factor (VEGF)-Activating Transcription Factor Modulates VEGF Signaling and Induces Therapeutic Angiogenesis After Hindlimb Ischemia

• Thomas Thum,
• Daniela Fraccarollo,
• Maximilian Schultheiss,
• Sabrina Froese,
• Paolo Galuppo,
• Julian D. Widder,
• Dimitrios Tsikas,
• Georg Ertl,
• and Johann Bauersachs

Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes

• Theodore Mazzone,
• Peter M. Meyer,
• George T. Kondos,
• Michael H. Davidson,
• Steven B. Feinstein,
• Ralph B. D’Agostino, Sr.,
• Alfonso Perez,
• and Steven M. Haffner

Relationship of Traditional and Nontraditional Cardiovascular Risk Factors to Coronary Artery Calcium in Type 2 Diabetes

• Carla J. Gallagher,
• Keith L. Keene,
• Josyf C. Mychaleckyj,
• Carl D. Langefeld,
• Joel N. Hirschhorn,
• Brian E. Henderson,
• Candace J. Gordon,
• Barry I. Freedman,
• Stephen S. Rich,
• Donald W. Bowden,
• and Michèle M. Sale

Investigation of the Estrogen Receptor-α Gene With Type 2 Diabetes and/or Nephropathy in African-American and European-American Populations

• Wendy Winckler,
• Michael N. Weedon,
• Robert R. Graham,
• Steven A. McCarroll,
• Shaun Purcell,
• Peter Almgren,
• Tiinamaija Tuomi,
• Daniel Gaudet,
• Kristina Bengtsson Boström,
• Mark Walker,
• Graham Hitman,
• Andrew T. Hattersley,
• Mark I. McCarthy,
• Kristin G. Ardlie,
• Joel N. Hirschhorn,
• Mark J. Daly,
• Timothy M. Frayling,
• Leif Groop,
• and David Altshuler

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

• Winston S. Chu,
• Swapan Kumar Das,
• Hua Wang,
• Juliana C. Chan,
• Panos Deloukas,
• Philippe Froguel,
• Leslie J. Baier,
• Weiping Jia,
• Mark I. McCarthy,
• Maggie C.Y. Ng,
• Coleen Damcott,
• Alan R. Shuldiner,
• Eleftheria Zeggini,
• and Steven C. Elbein

Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits

• Adam Kretowski,
• Kim McFann,
• John E. Hokanson,
• David Maahs,
• Gregory Kinney,
• Janet K. Snell-Bergeon,
• R. Paul Wadwa,
• Robert H. Eckel,
• Lorraine Ogden,
• Satish Garg,
• Jia Li,
• Suzanne Cheng,
• Henry A. Erlich,
• and Marian Rewers

Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis

• Abbas Dehghan,
• Isabella Kardys,
• Moniek P.M. de Maat,
• Andre G. Uitterlinden,
• Eric J.G. Sijbrands,
• Aart H. Bootsma,
• Theo Stijnen,
• Albert Hofman,
• Miranda T. Schram,
• and Jacqueline C.M. Witteman

Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes

• Lise Wegner,
• Gitte Andersen,
• Thomas Sparsø,
• Niels Grarup,
• Charlotte Glümer,
• Knut Borch-Johnsen,
• Torben Jørgensen,
• Torben Hansen,
• and Oluf Pedersen

Common Variation in LMNA Increases Susceptibility to Type 2 Diabetes and Associates With Elevated Fasting Glycemia and Estimates of Body Fat and Height in the General Population: Studies of 7,495 Danish Whites

• Fouad Atouf,
• Cheol Hong Park,
• Klaus Pechhold,
• Malancha Ta,
• Yong Choi,
• and Nadya L. Lumelsky

No Evidence for Mouse Pancreatic β-Cell Epithelial-Mesenchymal Transition In Vitro

• Ayse G. Kayali,
• Luis E. Flores,
• Ana D. Lopez,
• Burak Kutlu,
• Emmanuel Baetge,
• Ryuichi Kitamura,
• Ergeng Hao,
• Gillian M. Beattie,
• and Alberto Hayek

Limited Capacity of Human Adult Islets Expanded In Vitro to Redifferentiate Into Insulin-Producing β-Cells

• Luc Marchand and
• Constantin Polychronakos

Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene With Diabetes

• Karen Tan,
• Wendy A. Kimber,
• Jian’an Luan,
• Maria A. Soos,
• Robert K. Semple,
• Nicholas J. Wareham,
• Stephen O’Rahilly,
• and Inês Barroso

Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes

• Katharine R. Owen,
• Christopher J. Groves,
• Robert L. Hanson,
• William C. Knowler,
• Alan R. Shuldiner,
• Steven C. Elbein,
• Braxton D. Mitchell,
• Philippe Froguel,
• Maggie C.Y. Ng,
• Juliana C. Chan,
• Weiping Jia,
• Panos Deloukas,
• Graham A. Hitman,
• Mark Walker,
• Timothy M. Frayling,
• Andrew T. Hattersley,
• Eleftheria Zeggini,
• and Mark I. McCarthy

Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes: Association Analyses in 9,518 Subjects

• José L. Mesa,
• Ruth J.F. Loos,
• Paul W. Franks,
• Ken K. Ong,
• Jian’an Luan,
• Stephen O’Rahilly,
• Nicholas J. Wareham,
• and Inês Barroso

Lamin A/C Polymorphisms, Type 2 Diabetes, and the Metabolic Syndrome: Case-Control and Quantitative Trait Studies

• Alka Malhotra,
• Steven C. Elbein,
• Maggie C.Y. Ng,
• Ravindranath Duggirala,
• Rector Arya,
• Giuseppina Imperatore,
• Adebowale Adeyemo,
• Toni I. Pollin,
• Wen-Chi Hsueh,
• Juliana C.N. Chan,
• Charles Rotimi,
• Robert L. Hanson,
• Sandra J. Hasstedt,
• Johanna K. Wolford,
• and and the American Diabetes Association GENNID Study Group

Meta-Analysis of Genome-Wide Linkage Studies of Quantitative Lipid Traits in Families Ascertained for Type 2 Diabetes

• Barbara Ukropcova,
• Olga Sereda,
• Lilian de Jonge,
• Iwona Bogacka,
• Tuong Nguyen,
• Hui Xie,
• George A. Bray,
• and Steven R. Smith

Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle

• Amale Lteif,
• Prashant Vaishnava,
• Alain D. Baron,
• and Kieren J. Mather

Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans

• Edward Lin,
• Lawrence S. Phillips,
• Thomas R. Ziegler,
• Brian Schmotzer,
• Kongjun Wu,
• Li H. Gu,
• Leena Khaitan,
• Scott A. Lynch,
• William E. Torres,
• C. Daniel Smith,
• and Nana Gletsu-Miller

Increases in Adiponectin Predict Improved Liver, but Not Peripheral, Insulin Sensitivity in Severely Obese Women During Weight Loss

• Mandeep Bajaj,
• Rafael Medina-Navarro,
• Swangjit Suraamornkul,
• Christian Meyer,
• Ralph A. DeFronzo,
• and Lawrence J. Mandarino

Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration

• Rita Basu,
• Chiara Dalla Man,
• Marco Campioni,
• Ananda Basu,
• K. Sree Nair,
• Michael D. Jensen,
• Sundeep Khosla,
• George Klee,
• Gianna Toffolo,
• Claudio Cobelli,
• and Robert A. Rizza

Two Years of Treatment With Dehydroepiandrosterone Does Not Improve Insulin Secretion, Insulin Action, or Postprandial Glucose Turnover in Elderly Men or Women

• Wagner S. da-Silva,
• John W. Harney,
• Brian W. Kim,
• Jing Li,
• Suzy D.C. Bianco,
• Alessandra Crescenzi,
• Marcelo A. Christoffolete,
• Stephen A. Huang,
• and Antonio C. Bianco

The Small Polyphenolic Molecule Kaempferol Increases Cellular Energy Expenditure and Thyroid Hormone Activation

• Eunsook S. Jin,
• Byung-Hyun Park,
• A. Dean Sherry,
• and Craig R. Malloy

Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Pre-Diabetic and Diabetic Zucker (fa/fa) Rats

• Yoni Athéa,
• Benoît Viollet,
• Philippe Mateo,
• Delphine Rousseau,
• Marta Novotova,
• Anne Garnier,
• Sophie Vaulont,
• James R. Wilding,
• Alain Grynberg,
• Vladimir Veksler,
• Jacqueline Hoerter,
• and Renée Ventura-Clapier

AMP-Activated Protein Kinase α2 Deficiency Affects Cardiac Cardiolipin Homeostasis and Mitochondrial Function

• Yukiko Kanatani,
• Isao Usui,
• Ken Ishizuka,
• Agussalim Bukhari,
• Shiho Fujisaka,
• Masaharu Urakaze,
• Tetsuro Haruta,
• Tadamitsu Kishimoto,
• Tetsuji Naka,
• and Masashi Kobayashi

Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression: Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression

• Yoshiyuki Hattori,
• Sachiko Hattori,
• Kazumi Akimoto,
• Toshio Nishikimi,
• Kunihiro Suzuki,
• Hiroaki Matsuoka,
• and Kikuo Kasai

Globular Adiponectin Activates Nuclear Factor-κB and Activating Protein-1 and Enhances Angiotensin II–Induced Proliferation in Cardiac Fibroblasts

• Apiradee Sriwijitkamol,
• Dawn K. Coletta,
• Estela Wajcberg,
• Gabriela B. Balbontin,
• Sara M. Reyna,
• John Barrientes,
• Phyllis A. Eagan,
• Christopher P. Jenkinson,
• Eugenio Cersosimo,
• Ralph A. DeFronzo,
• Kei Sakamoto,
• and Nicolas Musi

Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes: A Time-Course and Dose-Response Study

Errata