Table of Contents

Obesity Studies

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- Naomi Hosogai,
- Atsunori Fukuhara,
- Kazuya Oshima,
- Yugo Miyata,
- Sachiyo Tanaka,
- Katsumori Segawa,
- Shigetada Furukawa,
- Yoshihiro Tochino,
- Ryutaro Komuro,
- Morihiro Matsuda,
- and Iichiro Shimomura
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Diabetes April 2007 56:901-911; doi:10.2337/db06-0911
Select this article
- Emmanuel Chevillotte,
- Marta Giralt,
- Bruno Miroux,
- Daniel Ricquier,
- and Francesc Villarroya
Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production
Diabetes April 2007 56:1042-1050; doi:10.2337/db06-1300
Select this article
- Deborah J. Clegg,
- Lynda M. Brown,
- Jeffrey M. Zigman,
- Christopher J. Kemp,
- April D. Strader,
- Stephen C. Benoit,
- Stephen C. Woods,
- Michela Mangiaracina,
- and Nori Geary
Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats
Diabetes April 2007 56:1051-1058; published ahead of print January 24, 2007, doi:10.2337/db06-0015

Immunology and Transplantation

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- Paolo Fiorina,
- Mollie Jurewicz,
- Katsunori Tanaka,
- Negin Behazin,
- Andrea Augello,
- Andrea Vergani,
- Uli Von Adrian,
- Neal R. Smith,
- Mohamed H. Sayegh,
- and Reza Abdi
Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21: A Novel Strategy to Prolong Islet Allograft Survival
Diabetes April 2007 56:912-920; published ahead of print February 7, 2007, doi:10.2337/db06-1445
Select this article
- Marianne M. Martinic,
- Amy E. Juedes,
- Damien Bresson,
- Dirk Homann,
- Kresten Skak,
- Christoph Huber,
- Eleanor Ling,
- Mette Ejrnaes,
- Tom Wolfe,
- Lisa Togher,
- Urs Christen,
- and Matthias G. von Herrath
Minimal Impact of a De Novo–Expressed β-Cell Autoantigen on Spontaneous Diabetes Development in NOD Mice
Diabetes April 2007 56:1059-1068; doi:10.2337/db05-0062

Islet Studies

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- Hsun Teresa Ku,
- Jing Chai,
- Yoon-Jung Kim,
- Peter White,
- Sheetal Purohit-Ghelani,
- Klaus H. Kaestner,
- and Jonathan S. Bromberg
Insulin-Expressing Colonies Developed From Murine Embryonic Stem Cell–Derived Progenitors
Diabetes April 2007 56:921-929; doi:10.2337/db06-0468
Select this article
- Natalia A. Kaniuk,
- Michael Kiraly,
- Holly Bates,
- Mladen Vranic,
- Allen Volchuk,
- and John H. Brumell
Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy
Diabetes April 2007 56:930-939; doi:10.2337/db06-1160
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- Maria Carmen Puertas,
- Jorge Carrillo,
- Xavier Pastor,
- Rosa Maria Ampudia,
- Aurora Alba,
- Raquel Planas,
- Ricardo Pujol-Borrell,
- Marta Vives-Pi,
- and Joan Verdaguer
Phenotype and Functional Characteristics of Islet-Infiltrating B-Cells Suggest the Existence of Immune Regulatory Mechanisms in Islet Milieu
Diabetes April 2007 56:940-949; doi:10.2337/db06-0428
Select this article
- Aouatef Ait-Lounis,
- Dominique Baas,
- Emmanuèle Barras,
- Carine Benadiba,
- Anne Charollais,
- Rachel Nlend Nlend,
- Delphine Liègeois,
- Paolo Meda,
- Bénédicte Durand,
- and Walter Reith
Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas
Diabetes April 2007 56:950-959; published ahead of print January 17, 2007, doi:10.2337/db06-1187
Select this article
- Pierre Pirot,
- Fernanda Ortis,
- Miriam Cnop,
- Yanjun Ma,
- Linda M. Hendershot,
- Décio L. Eizirik,
- and Alessandra K. Cardozo
Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells
Diabetes April 2007 56:1069-1077; doi:10.2337/db06-1253
Select this article
- Stephan Speier,
- Asllan Gjinovci,
- Anne Charollais,
- Paolo Meda,
- and Marjan Rupnik
Cx36-Mediated Coupling Reduces β-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics
Diabetes April 2007 56:1078-1086; doi:10.2337/db06-0232
Select this article
- Martin G. Latour,
- Thierry Alquier,
- Elizabeth Oseid,
- Caroline Tremblay,
- Thomas L. Jetton,
- Jian Luo,
- Daniel C.-H. Lin,
- and Vincent Poitout
GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo
Diabetes April 2007 56:1087-1094; doi:10.2337/db06-1532
Select this article
- Zuheng Ma,
- Neil Portwood,
- David Brodin,
- Valdemar Grill,
- and Anneli Björklund
Effects of Diazoxide on Gene Expression in Rat Pancreatic Islets Are Largely Linked to Elevated Glucose and Potentially Serve to Enhance β-Cell Sensitivity
Diabetes April 2007 56:1095-1106; published ahead of print January 17, 2007, doi:10.2337/db06-0322
Select this article
- Huarong Zhou,
- Tao Zhang,
- Jamie S. Harmon,
- Joseph Bryan,
- and R. Paul Robertson
Zinc, Not Insulin, Regulates the Rat α-Cell Response to Hypoglycemia In Vivo
Diabetes April 2007 56:1107-1112; published ahead of print February 22, 2007, doi:10.2337/db06-1454

Complications

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- Sergio Caballero,
- Nilanjana Sengupta,
- Aqeela Afzal,
- Kyung-Hee Chang,
- Sergio Li Calzi,
- Dennis L. Guberski,
- Timothy S. Kern,
- and Maria B. Grant
Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells
Diabetes April 2007 56:960-967; doi:10.2337/db06-1254
Select this article
- Richard J.M. Coward,
- Gavin I. Welsh,
- Ania Koziell,
- Sagair Hussain,
- Rachel Lennon,
- Lan Ni,
- Jeremy M. Tavaré,
- Peter W. Mathieson,
- and Moin A. Saleem
Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes
Diabetes April 2007 56:1127-1135; doi:10.2337/db06-0693
Select this article
- Jérémy Fauconnier,
- Daniel C. Andersson,
- Shi-Jin Zhang,
- Johanna T. Lanner,
- Rolf Wibom,
- Abram Katz,
- Joseph D. Bruton,
- and Håkan Westerblad
Effects of Palmitate on Ca²⁺ Handling in Adult Control and ob/ob Cardiomyocytes : Impact of Mitochondrial Reactive Oxygen Species
Diabetes April 2007 56:1136-1142; published ahead of print January 17, 2007, doi:10.2337/db06-0739
Select this article
- Bardia Askari,
- Jenny E. Kanter,
- Ashley M. Sherrid,
- Deidre L. Golej,
- Andrew T. Bender,
- Joey Liu,
- Willa A. Hsueh,
- Joseph A. Beavo,
- Rosalind A. Coleman,
- and Karin E. Bornfeldt
Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor-γ–Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages
Diabetes April 2007 56:1143-1152; published ahead of print January 26, 2007, doi:10.2337/db06-0267

Pharmacology and Therapeutics

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- Katarína Šebeková,
- Timo Eifert,
- André Klassen,
- August Heidland,
- and Kerstin Amann
Renal Effects of S18886 (Terutroban), a TP Receptor Antagonist, in an Experimental Model of Type 2 Diabetes
Diabetes April 2007 56:968-974; published ahead of print January 31, 2007, doi:10.2337/db06-1136
Select this article
- John M. Lachin,
- Costas A. Christophi,
- Sharon L. Edelstein,
- David A. Ehrmann,
- Richard F. Hamman,
- Steven E. Kahn,
- William C. Knowler,
- and David M. Nathan
Factors Associated With Diabetes Onset During Metformin Versus Placebo Therapy in the Diabetes Prevention Program
Diabetes April 2007 56:1153-1159; doi:10.2337/db06-0918

Genetics

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- Robert L. Hanson,
- David W. Craig,
- Meredith P. Millis,
- Kimberly A. Yeatts,
- Sayuko Kobes,
- John V. Pearson,
- Anne M. Lee,
- William C. Knowler,
- Robert G. Nelson,
- and Johanna K. Wolford
Identification of PVT1 as a Candidate Gene for End-Stage Renal Disease in Type 2 Diabetes Using a Pooling-Based Genome-Wide Single Nucleotide Polymorphism Association Study
Diabetes April 2007 56:975-983; doi:10.2337/db06-1072
Select this article
- Helen C. Looker,
- Robert G. Nelson,
- Emily Chew,
- Ronald Klein,
- Barbara E.K. Klein,
- William C. Knowler,
- and Robert L. Hanson
Genome-Wide Linkage Analyses to Identify Loci for Diabetic Retinopathy
Diabetes April 2007 56:1160-1166; doi:10.2337/db06-1299
Select this article
- D. Michael Hallman,
- Eric Boerwinkle,
- Victor H. Gonzalez,
- Barbara E. K. Klein,
- Ronald Klein,
- and Craig L. Hanis
A Genome-Wide Linkage Scan for Diabetic Retinopathy Susceptibility Genes in Mexican Americans With Type 2 Diabetes From Starr County, Texas
Diabetes April 2007 56:1167-1173; published ahead of print January 24, 2007, doi:10.2337/db06-1373

Metabolism

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- Naveed Sattar,
- Alex McConnachie,
- Ian Ford,
- Allan Gaw,
- Stephen J. Cleland,
- Nita G. Forouhi,
- Peter McFarlane,
- James Shepherd,
- Stuart Cobbe,
- and Chris Packard
Serial Metabolic Measurements and Conversion to Type 2 Diabetes in the West of Scotland Coronary Prevention Study: Specific Elevations in Alanine Aminotransferase and Triglycerides Suggest Hepatic Fat Accumulation as a Potential Contributing Factor
Diabetes April 2007 56:984-991; doi:10.2337/db06-1256
Select this article
- Emmanuelle Meugnier,
- May Faraj,
- Sophie Rome,
- Geneviève Beauregard,
- Angélique Michaut,
- Véronique Pelloux,
- Jean-Louis Chiasson,
- Martine Laville,
- Karine Clement,
- Hubert Vidal,
- and Rémi Rabasa-Lhoret
Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects
Diabetes April 2007 56:992-999; published ahead of print February 15, 2007, doi:10.2337/db06-1242
Select this article
- Yasuo Okamoto,
- Wataru Ogawa,
- Akihiko Nishizawa,
- Hiroshi Inoue,
- Kiyoshi Teshigawara,
- Shinichi Kinoshita,
- Yasushi Matsuki,
- Eijiro Watanabe,
- Ryuji Hiramatsu,
- Hiroshi Sakaue,
- Tetsuo Noda,
- and Masato Kasuga
Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1
Diabetes April 2007 56:1000-1009; published ahead of print January 31, 2007, doi:10.2337/db06-1322
Select this article
- Luigi Fontana,
- J. Christopher Eagon,
- Maria E. Trujillo,
- Philipp E. Scherer,
- and Samuel Klein
Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans
Diabetes April 2007 56:1010-1013; published ahead of print February 7, 2007, doi:10.2337/db06-1656

Signal Transduction

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- Henrique G. Zecchin,
- Fernanda B.M. Priviero,
- Claudio T. Souza,
- Karina G. Zecchin,
- Patrícia O. Prada,
- José B.C. Carvalheira,
- Licio A. Velloso,
- Edson Antunes,
- and Mario J.A. Saad
Defective Insulin and Acetylcholine Induction of Endothelial Cell–Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats
Diabetes April 2007 56:1014-1024; published ahead of print January 17, 2007, doi:10.2337/db05-1147
Select this article
- Julio E. Ayala,
- Deanna P. Bracy,
- Brianna M. Julien,
- Jeffrey N. Rottman,
- Patrick T. Fueger,
- and David H. Wasserman
Chronic Treatment With Sildenafil Improves Energy Balance and Insulin Action in High Fat–Fed Conscious Mice
Diabetes April 2007 56:1025-1033; published ahead of print January 17, 2007, doi:10.2337/db06-0883
Select this article
- Susanne Neschen,
- Katsutaro Morino,
- Jianying Dong,
- Yanlin Wang-Fischer,
- Gary W. Cline,
- Anthony J. Romanelli,
- Jörg C. Rossbacher,
- Irene K. Moore,
- Werner Regittnig,
- David S. Munoz,
- Jung H. Kim,
- and Gerald I. Shulman
n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner
Diabetes April 2007 56:1034-1041; published ahead of print January 24, 2007, doi:10.2337/db06-1206

Pathophysiology

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- Gerlies Bock,
- Chiara Dalla Man,
- Marco Campioni,
- Elizabeth Chittilapilly,
- Rita Basu,
- Gianna Toffolo,
- Claudio Cobelli,
- and Robert Rizza
Effects of Nonglucose Nutrients on Insulin Secretion and Action in People With Pre-Diabetes
Diabetes April 2007 56:1113-1119; doi:10.2337/db06-1272
Select this article
- Owen Chan,
- Marcus Lawson,
- Wanling Zhu,
- Joseph Lee Beverly,
- and Robert S. Sherwin
ATP-Sensitive K⁺ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia
Diabetes April 2007 56:1120-1126; published ahead of print January 24, 2007, doi:10.2337/db06-1102

Brief Reports

Select this article
- Hui-Qi Qu,
- Alexander Montpetit,
- Bing Ge,
- Thomas J. Hudson,
- and Constantin Polychronakos
Toward Further Mapping of the Association Between the IL2RA Locus and Type 1 Diabetes
Diabetes April 2007 56:1174-1176; doi:10.2337/db06-1555
Select this article
- Hsing-Yi Lin,
- Chiao-Ling Wang,
- Pi-Jung Hsiao,
- Yung-Chuan Lu,
- Su-Yu Chen,
- Kun-Der Lin,
- Shih-Chie Hsin,
- Ming-Chia Hsieh,
- and Shyi-Jang Shin
SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes
Diabetes April 2007 56:1177-1180; published ahead of print January 17, 2007, doi:10.2337/db06-1283
Select this article
- Laura Andrulionytė,
- Teemu Kuulasmaa,
- Jean-Louis Chiasson,
- and Markku Laakso
Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor-α Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes : The STOP-NIDDM Trial
Diabetes April 2007 56:1181-1186; published ahead of print February 22, 2007, doi:10.2337/db06-1110

Diabetes

Obesity Studies

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production

Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats

Immunology and Transplantation

Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21: A Novel Strategy to Prolong Islet Allograft Survival

Minimal Impact of a De Novo–Expressed β-Cell Autoantigen on Spontaneous Diabetes Development in NOD Mice

Islet Studies

Insulin-Expressing Colonies Developed From Murine Embryonic Stem Cell–Derived Progenitors

Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy

Phenotype and Functional Characteristics of Islet-Infiltrating B-Cells Suggest the Existence of Immune Regulatory Mechanisms in Islet Milieu

Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

Cx36-Mediated Coupling Reduces β-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

Effects of Diazoxide on Gene Expression in Rat Pancreatic Islets Are Largely Linked to Elevated Glucose and Potentially Serve to Enhance β-Cell Sensitivity

Zinc, Not Insulin, Regulates the Rat α-Cell Response to Hypoglycemia In Vivo

Complications

Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

Effects of Palmitate on Ca2+ Handling in Adult Control and ob/ob Cardiomyocytes : Impact of Mitochondrial Reactive Oxygen Species

Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor-γ–Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages

Pharmacology and Therapeutics

Renal Effects of S18886 (Terutroban), a TP Receptor Antagonist, in an Experimental Model of Type 2 Diabetes

Factors Associated With Diabetes Onset During Metformin Versus Placebo Therapy in the Diabetes Prevention Program

Genetics

Identification of PVT1 as a Candidate Gene for End-Stage Renal Disease in Type 2 Diabetes Using a Pooling-Based Genome-Wide Single Nucleotide Polymorphism Association Study

Genome-Wide Linkage Analyses to Identify Loci for Diabetic Retinopathy

A Genome-Wide Linkage Scan for Diabetic Retinopathy Susceptibility Genes in Mexican Americans With Type 2 Diabetes From Starr County, Texas

Metabolism

Serial Metabolic Measurements and Conversion to Type 2 Diabetes in the West of Scotland Coronary Prevention Study: Specific Elevations in Alanine Aminotransferase and Triglycerides Suggest Hepatic Fat Accumulation as a Potential Contributing Factor

Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects

Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1

Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans

Signal Transduction

Defective Insulin and Acetylcholine Induction of Endothelial Cell–Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats

Chronic Treatment With Sildenafil Improves Energy Balance and Insulin Action in High Fat–Fed Conscious Mice

n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Pathophysiology

Effects of Nonglucose Nutrients on Insulin Secretion and Action in People With Pre-Diabetes

ATP-Sensitive K+ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia

Brief Reports

Toward Further Mapping of the Association Between the IL2RA Locus and Type 1 Diabetes

SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes

Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor-α Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes : The STOP-NIDDM Trial

This Issue

Current Issue

Effects of Palmitate on Ca²⁺ Handling in Adult Control and ob/ob Cardiomyocytes : Impact of Mitochondrial Reactive Oxygen Species

ATP-Sensitive K⁺ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia