Table of Contents

June 2007; 56 (6)

Banting Lecture 2006

Perspectives in Diabetes

    • Thomas A. Buchanan

    (How) Can We Prevent Type 2 Diabetes?

    Diabetes June 2007 56:1502-1507; published ahead of print March 27, 2007, doi:10.2337/db07-0140

Signal Transduction

    • Zhengping Yi,
    • Paul Langlais,
    • Elena A. De Filippis,
    • Moulun Luo,
    • Charles R. Flynn,
    • Stefanie Schroeder,
    • Susan T. Weintraub,
    • Rebekka Mapes,
    • and Lawrence J. Mandarino

    Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

    Diabetes June 2007 56:1508-1516; published ahead of print March 14, 2007, doi:10.2337/db06-1355
    • Ursula A. White,
    • Ann A. Coulter,
    • Tiffany K. Miles,
    • and Jacqueline M. Stephens

    The STAT5A-Mediated Induction of Pyruvate Dehydrogenase Kinase 4 Expression by Prolactin or Growth Hormone in Adipocytes

    Diabetes June 2007 56:1623-1629; published ahead of print March 14, 2007, doi:10.2337/db06-1286
    • Stephan Glund,
    • Atul Deshmukh,
    • Yun Chau Long,
    • Theodore Moller,
    • Heikki A. Koistinen,
    • Kenneth Caidahl,
    • Juleen R. Zierath,
    • and Anna Krook

    Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle

    Diabetes June 2007 56:1630-1637; published ahead of print March 15, 2007, doi:10.2337/db06-1733
    • Juan-Pablo del Rincon,
    • Keiji Iida,
    • Bruce D. Gaylinn,
    • Carrie E. McCurdy,
    • J. Wayne Leitner,
    • Linda A. Barbour,
    • John J. Kopchick,
    • Jacob E. Friedman,
    • Boris Draznin,
    • and Michael O. Thorner

    Growth Hormone Regulation of p85α Expression and Phosphoinositide 3-Kinase Activity in Adipose Tissue: Mechanism for Growth Hormone–Mediated Insulin Resistance

    Diabetes June 2007 56:1638-1646; published ahead of print March 15, 2007, doi:10.2337/db06-0299

Obesity Studies

    • Satoshi Nishimura,
    • Ichiro Manabe,
    • Mika Nagasaki,
    • Yumiko Hosoya,
    • Hiroshi Yamashita,
    • Hideo Fujita,
    • Mitsuru Ohsugi,
    • Kazuyuki Tobe,
    • Takashi Kadowaki,
    • Ryozo Nagai,
    • and Seiryo Sugiura

    Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels

    Diabetes June 2007 56:1517-1526; published ahead of print March 27, 2007, doi:10.2337/db06-1749
    • Yiying Zhang,
    • Kaiying Guo,
    • Robert E. LeBlanc,
    • Daniella Loh,
    • Gary J. Schwartz,
    • and Yi-Hao Yu

    Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms

    Diabetes June 2007 56:1647-1654; published ahead of print March 14, 2007, doi:10.2337/db07-0123
    • Celia M. de Souza Batista,
    • Rong-Ze Yang,
    • Mi-Jeong Lee,
    • Nicole M. Glynn,
    • Dao-Zhan Yu,
    • Jessica Pray,
    • Kelechi Ndubuizu,
    • Susheel Patil,
    • Alan Schwartz,
    • Mark Kligman,
    • Susan K. Fried,
    • Da-Wei Gong,
    • Alan R. Shuldiner,
    • Toni I. Pollin,
    • and John C. McLenithan

    Omentin Plasma Levels and Gene Expression Are Decreased in Obesity

    Diabetes June 2007 56:1655-1661; published ahead of print February 28, 2007, doi:10.2337/db06-1506
    • Takafumi Nakamachi,
    • Takashi Nomiyama,
    • Florence Gizard,
    • Elizabeth B. Heywood,
    • Karrie L. Jones,
    • Yue Zhao,
    • Lucia Fuentes,
    • Kohzo Takebayashi,
    • Yoshimasa Aso,
    • Bart Staels,
    • Toshihiko Inukai,
    • and Dennis Bruemmer

    PPARα Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes

    Diabetes June 2007 56:1662-1670; published ahead of print March 14, 2007, doi:10.2337/db06-1177
    • Young-Sun Lee,
    • Seungjin Shin,
    • Toshikatsu Shigihara,
    • Eunsil Hahm,
    • Meng-Ju Liu,
    • Jaeseok Han,
    • Ji-Won Yoon,
    • and Hee-Sook Jun

    Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis

    Diabetes June 2007 56:1671-1679; published ahead of print March 16, 2007, doi:10.2337/db06-1182
    • Wilfred Y. Fujimoto,
    • Kathleen A. Jablonski,
    • George A. Bray,
    • Andrea Kriska,
    • Elizabeth Barrett-Connor,
    • Steven Haffner,
    • Robert Hanson,
    • James O. Hill,
    • Van Hubbard,
    • E. Stamm,
    • and F. Xavier Pi-Sunyer

    Body Size and Shape Changes and the Risk of Diabetes in the Diabetes Prevention Program

    Diabetes June 2007 56:1680-1685; published ahead of print March 15, 2007, doi:10.2337/db07-0009

Immunology and Transplantation

    • Anja Mayr,
    • Michael Schlosser,
    • Natalie Grober,
    • Heidrun Kenk,
    • Anette G. Ziegler,
    • Ezio Bonifacio,
    • and Peter Achenbach

    GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes

    Diabetes June 2007 56:1527-1533; published ahead of print February 26, 2007, doi:10.2337/db06-1715
    • Aito Ueno,
    • Suzanne Cho,
    • Lu Cheng,
    • Jianxiong Wang,
    • Sheng Hou,
    • Hiroko Nakano,
    • Pere Santamaria,
    • and Yang Yang

    Transient Upregulation of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Human Chorionic Gonadotropin Downregulates Autoimmune Diabetes

    Diabetes June 2007 56:1686-1693; published ahead of print March 14, 2007, doi:10.2337/db06-1727

Islet Studies

    • Sung Sik Choe,
    • A Hyun Choi,
    • Joo-Won Lee,
    • Kang Ho Kim,
    • Jun-Jae Chung,
    • Jiyoung Park,
    • Kyeong-Min Lee,
    • Keun-Gyu Park,
    • In-Kyu Lee,
    • and Jae Bum Kim

    Chronic Activation of Liver X Receptor Induces β-Cell Apoptosis Through Hyperactivation of Lipogenesis: Liver X Receptor–Mediated Lipotoxicity in Pancreatic β-Cells

    Diabetes June 2007 56:1534-1543; published ahead of print March 16, 2007, doi:10.2337/db06-1059
    • Joey Lau,
    • Göran Mattsson,
    • Carina Carlsson,
    • Daniel Nyqvist,
    • Martin Köhler,
    • Per-Olof Berggren,
    • Leif Jansson,
    • and Per-Ola Carlsson

    Implantation Site–Dependent Dysfunction of Transplanted Pancreatic Islets

    Diabetes June 2007 56:1544-1550; published ahead of print March 30, 2007, doi:10.2337/db06-1258
    • Daniel Johnson,
    • Ruth M. Shepherd,
    • Debra Gill,
    • Tracy Gorman,
    • David M. Smith,
    • and Mark J. Dunne

    Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator

    Diabetes June 2007 56:1694-1702; published ahead of print March 14, 2007, doi:10.2337/db07-0026
    • Gerlies Bock,
    • Elizabeth Chittilapilly,
    • Rita Basu,
    • Gianna Toffolo,
    • Claudio Cobelli,
    • Visvanathan Chandramouli,
    • Bernard R. Landau,
    • and Robert A. Rizza

    Contribution of Hepatic and Extrahepatic Insulin Resistance to the Pathogenesis of Impaired Fasting Glucose: Role of Increased Rates of Gluconeogenesis

    Diabetes June 2007 56:1703-1711; published ahead of print March 23, 2007, doi:10.2337/db06-1776

Pathophysiology

    • Gang Xu,
    • Hideaki Kaneto,
    • D. Ross Laybutt,
    • Valerie F. Duvivier-Kali,
    • Nitin Trivedi,
    • Kiyoshi Suzuma,
    • George L. King,
    • Gordon C. Weir,
    • and Susan Bonner-Weir

    Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes

    Diabetes June 2007 56:1551-1558; published ahead of print March 14, 2007, doi:10.2337/db06-1033
    • Robert K. Semple,
    • Nils H. Halberg,
    • Keith Burling,
    • Maria A. Soos,
    • Todd Schraw,
    • Jian'an Luan,
    • Elaine K. Cochran,
    • David B. Dunger,
    • Nicholas J. Wareham,
    • Philipp E. Scherer,
    • Phillip Gorden,
    • and Stephen O'Rahilly

    Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies

    Diabetes June 2007 56:1712-1717; published ahead of print February 26, 2007, doi:10.2337/db06-1665

Complications

    • Yung-Hsiang Chen,
    • Shing-Jong Lin,
    • Feng-Yen Lin,
    • Tao-Cheng Wu,
    • Chen-Rong Tsao,
    • Po-Hsun Huang,
    • Po-Len Liu,
    • Yuh-Lien Chen,
    • and Jaw-Wen Chen

    High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms

    Diabetes June 2007 56:1559-1568; published ahead of print March 26, 2007, doi:10.2337/db06-1103
    • Khara M. Ramos,
    • Yun Jiang,
    • Camilla I. Svensson,
    • and Nigel A. Calcutt

    Pathogenesis of Spinally Mediated Hyperalgesia in Diabetes

    Diabetes June 2007 56:1569-1576; published ahead of print February 7, 2007, doi:10.2337/db06-1269
    • Sudha K. Iyengar,
    • Hanna E. Abboud,
    • Katrina A.B. Goddard,
    • Mohammed F. Saad,
    • Sharon G. Adler,
    • Nedal H. Arar,
    • Donald W. Bowden,
    • Ravi Duggirala,
    • Robert C. Elston,
    • Robert L. Hanson,
    • Eli Ipp,
    • W.H. Linda Kao,
    • Paul L. Kimmel,
    • Michael J. Klag,
    • William C. Knowler,
    • Lucy A. Meoni,
    • Robert G. Nelson,
    • Susanne B. Nicholas,
    • Madeleine V. Pahl,
    • Rulan S. Parekh,
    • Shannon R.E. Quade,
    • Stephen S. Rich,
    • Jerome I. Rotter,
    • Marina Scavini,
    • Jeffrey R. Schelling,
    • John R. Sedor,
    • Ashwini R. Sehgal,
    • Vallabh O. Shah,
    • Michael W. Smith,
    • Kent D. Taylor,
    • Cheryl A. Winkler,
    • Philip G. Zager,
    • and Barry I. Freedman

    Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

    Diabetes June 2007 56:1577-1585; published ahead of print March 15, 2007, doi:10.2337/db06-1154
    • Lu Qi,
    • Alessandro Doria,
    • Elena Giorgi,
    • and Frank B. Hu

    Variations in Adiponectin Receptor Genes and Susceptibility to Type 2 Diabetes in Women: A Tagging–Single Nucleotide Polymorphism Haplotype Analysis

    Diabetes June 2007 56:1586-1591; published ahead of print April 6, 2007, doi:10.2337/db06-1447
    • Erik Ingelsson,
    • Lisa M. Sullivan,
    • Joanne M. Murabito,
    • Caroline S. Fox,
    • Emelia J. Benjamin,
    • Joseph F. Polak,
    • James B. Meigs,
    • Michelle J. Keyes,
    • Christopher J. O'Donnell,
    • Thomas J. Wang,
    • Ralph B. D'Agostino, Sr.,
    • Philip A. Wolf,
    • and Ramachandran S. Vasan

    Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes

    Diabetes June 2007 56:1718-1726; published ahead of print March 16, 2007, doi:10.2337/db07-0078

Metabolism

    • Martin Mogensen,
    • Kent Sahlin,
    • Maria Fernström,
    • Dorte Glintborg,
    • Birgitte F. Vind,
    • Henning Beck-Nielsen,
    • and Kurt Højlund

    Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

    Diabetes June 2007 56:1592-1599; published ahead of print March 9, 2007, doi:10.2337/db06-0981
    • Michael Krebs,
    • Barbara Brunmair,
    • Attila Brehm,
    • Michaela Artwohl,
    • Julia Szendroedi,
    • Peter Nowotny,
    • Erich Roth,
    • Clemens Fürnsinn,
    • Miriam Promintzer,
    • Christian Anderwald,
    • Martin Bischof,
    • and Michael Roden

    The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man

    Diabetes June 2007 56:1600-1607; published ahead of print February 28, 2007, doi:10.2337/db06-1016
    • Kirsten F. Howlett,
    • Kei Sakamoto,
    • Andrew Garnham,
    • David Cameron-Smith,
    • and Mark Hargreaves

    Resistance Exercise and Insulin Regulate AS160 and Interaction With 14-3-3 in Human Skeletal Muscle

    Diabetes June 2007 56:1608-1614; published ahead of print March 16, 2007, doi:10.2337/db06-1398
    • Satoshi Fujita,
    • Blake B. Rasmussen,
    • Jerson G. Cadenas,
    • Micah J. Drummond,
    • Erin L. Glynn,
    • Fred R. Sattler,
    • and Elena Volpi

    Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling

    Diabetes June 2007 56:1615-1622; published ahead of print March 9, 2007, doi:10.2337/db06-1566

Brief Reports

    • Shin-ichi Araki,
    • Masakazu Haneda,
    • Daisuke Koya,
    • Hideki Hidaka,
    • Toshiro Sugimoto,
    • Motohide Isono,
    • Keiji Isshiki,
    • Masami Chin-Kanasaki,
    • Takashi Uzu,
    • and Atsunori Kashiwagi

    Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

    Diabetes June 2007 56:1727-1730; published ahead of print March 14, 2007, doi:10.2337/db06-1646
    • Robert H. Wallis,
    • KeSheng Wang,
    • Dominika Dabrowski,
    • Leili Marandi,
    • Terri Ning,
    • Eugene Hsieh,
    • Andrew D. Paterson,
    • John P. Mordes,
    • Elisabeth P. Blankenhorn,
    • and Philippe Poussier

    A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes

    Diabetes June 2007 56:1731-1736; published ahead of print March 27, 2007, doi:10.2337/db06-1790
    • Martine Vaxillaire,
    • Aurélie Dechaume,
    • Kanetee Busiah,
    • Hélène Cavé,
    • Sabrina Pereira,
    • Raphael Scharfmann,
    • Guiomar Perez de Nanclares,
    • Luis Castano,
    • Philippe Froguel,
    • and Michel Polak

    New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features

    Diabetes June 2007 56:1737-1741; published ahead of print March 27, 2007, doi:10.2337/db06-1540
    • Delphine Fradin,
    • Simon Heath,
    • Mark Lathrop,
    • and Pierre Bougnères

    Quantitative Trait Loci for Fasting Glucose in Young Europeans Replicate Previous Findings for Type 2 Diabetes in 2q23–24 and Other Locations

    Diabetes June 2007 56:1742-1745; published ahead of print April 6, 2007, doi:10.2337/db06-1329

Erratum

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This Issue

June 2007; 56 (6)
  1. Banting Lecture 2006
  2. Perspectives in Diabetes
  3. Signal Transduction
  4. Obesity Studies
  5. Immunology and Transplantation
  6. Islet Studies
  7. Pathophysiology
  8. Complications
  9. Metabolism
  10. Brief Reports
  11. Erratum

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