Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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High-fat feeding increased endotoxemia and changed intestinal microbiota. A: Plasma LPS concentration (EU/ml) was assessed every 4 h throughout the day in normal diet (CT; n = 9) (▪) and 4-week high-fat–fed (HF; n = 9) (○) mice. B: Groups of bacteria in the caecal content of mice fed the normal diet (CT; n = 8) or the high-fat diet (HF; n = 8) for 4 weeks. Bacterial numbers are expressed as log10 (bacterial cells per gram caecal content wet weight). *P < 0.05 vs. CT. C: Delta plasma LPS concentration in (EU/ml) in mice before and 30 min after an oral administration of LPS diluted in corn
oil (n = 6) (oil-LPS) or in water (n = 6) (H2O-LPS) or an administration of oil alone (n = 6) (oil). *P < 0.05 vs. H2O-LPS. Data are means ± SE.