Metabolic endotoxemia triggers the expression of inflammatory factors similarly to high-fat feeding. TNF-α, IL-1, IL-6, and
PAI-1 mRNA concentrations (A, E, and I) in liver (B, F, and J), visceral adipose tissue (C, G, and K), subcutaneous adipose tissue (D, H, and L), and muscle in normal diet–fed (n = 8) (□) or high-fat diet–fed (n = 8) (▪) mice for 2 weeks (A–D) and 4 weeks (n = 8) (E–H) and in LPS-infused mice (n = 5) (I–L). Data are means ± SE. *P < 0.05 vs. normal chow–fed mice.