Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

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FIG. 4.
FIG. 4.

CD14 mutant mice are protected against LPS-induced inflammation. mRNA concentrations of IL-6, PAI-1, and IL-1 in adipose tissue 3 h after a saline (control [CT]; n = 6) or an LPS (n = 6) infusion in WT (A) and CD14 mutant (B) mice. *P < 0.05 vs. CT; §P < 0.05 vs. WT. C: Representative Western blot analysis of p-NFk-B and p-IKK-b and p-IKK-a in the liver of mice from the same experiment. Protein Ct corresponds to a loading control of major protein, which cross-reacts nonspecifically with the anti–p-IKK-a antibody.

This Article

  1. Diabetes vol. 56 no. 7 1761-1772