Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

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FIG. 6.FIG. 6.FIG. 6.
FIG. 6.

CD14: the main LPS receptor sets the tone of insulin sensitivity and hepatic steatosis. A: Glucose turnover (mg · kg−1 · min−1) in WT mice or CD14 mutant fed a normal diet (CT) or fed a high-fat diet (HF) for 4 (n = 8) or 24 (n = 8) weeks (wks). B: Body weight gain (g) in WT or CD14 mutant fed a normal diet (CT) for 4 (n = 8) or 24 (n = 8) weeks or fed a high-fat diet (HF) for 4 (n = 8) or 24 (n = 8) weeks. C: Liver weight (percent of body weight) in WT or CD14 mutant mice fed a normal diet (CT) for 4 (n = 8) or 24 (n = 8) weeks or fed a high-fat diet (HF) for 4 (n = 8) or 24 (n = 8) weeks. D: Liver triglycerides (μmol/liver) in WT or CD14 mutant mice fed a normal diet (CT) for 4 (n = 6) or 24 (n = 5) weeks or fed a high-fat diet (HF) for 4 (n = 5) or 24 (n = 5) weeks. Data are means ± SE. *P < 0.05 vs. CT; §P < 0.05 vs. WT. E: Representative oil red O liver staining in 4-week–treated mice. F (see next page): Plasma glucose following an intraperitoneal glucose load (1 g/kg) in WT mice fed a normal diet (WT-CT; n = 8) or a high-fat diet (WT-HF; n = 8) for 24 weeks and CD14 mutant mice fed a normal diet (CD14-CT; n = 8) or fed a high-fat diet (CD14-HF; n = 8). The inset represents the area under curve of the same groups. G (see next page): Fasting plasma insulin (pmol/l) in WT or CD14 mutant mice fed a normal diet (CT) for 4 (n = 6) or 24 (n = 5) weeks or fed a high-fat diet (HF) for 4 (n = 5) or 24 (n = 5) weeks. Data are means ± SE. *P < 0.05 vs. CT; §P < 0.05 vs. WT. Data with different superscript letters are significantly different at P < 0.05, according to the post hoc ANOVA statistical analysis.

This Article

  1. Diabetes vol. 56 no. 7 1761-1772