Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

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FIG. 8.FIG. 8.
FIG. 8.

Metabolic endotoxemia impairs adipocyte morphology. A: Adipocyte size distribution (%) in WT mice fed a normal diet (WT-CT; n = 765) (□) or a high-fat diet (WT-HF; n = 661) (▪) for 4 weeks or CD14 mutant mice fed a normal diet (CD14-CT; n = 1,032) ( ▒) or a high-fat diet (CD14-HF; n = 729) (Graphic) for 4 weeks. B: Adipocyte size distribution (%) in WT mice infused with saline (WT-CT; n = 765) (□) or LPS (WT-LPS; n = 750) (▪) and CD14 mutant mice infused with saline (CD14-CT; n = 1,032) (▒) or LPS (CD14-LPS; n = 585) (Graphic) for 4 weeks using subcutaneous osmotic pumps. C: Adipocyte mean area (μm2) in WT-CT (n = 765), WT-HF (n = 661), WT-LPS (n = 750), CD14-CT (n = 1,032), CD14-HF (n = 729), or CD14-LPS (n = 585) mice. D: Representative adipose tissue staining in 4-week–treated mice. E: F4/80-positive cells (+ cells/total cells) of all above groups. Data are means ± SE. Data with different superscript letters are significantly different at P < 0.05, according to the post hoc ANOVA statistical analysis.

This Article

  1. Diabetes vol. 56 no. 7 1761-1772