Awakening and Counterregulatory Response to Hypoglycemia During Early and Late Sleep

TABLE 1

Percent of time spent awake and in the different sleep stages (S1, S2, SWS, and REM), and percent of epochs containing movements during a 70-min interval including 60 min of insulin infusion and the succeeding 10-min period, for early and late sleep hypoglycemia and for respective intervals in the control nights

Early sleep
Late sleep
P
Control night Hypoglycemia night Control night Hypoglycemia night Early/late Hypoglycemia Early/late* hypoglycemia
Wake (%) 0 ± 0 6 ± 3 1 ± 0 6 ± 1 0.981 0.001 0.717
S1 (%) 8 ± 3 12 ± 3 16 ± 6 27 ± 6 0.023 0.053 0.429
S2 (%) 57 ± 6 54 ± 6 55 ± 7 52 ± 6 0.639 0.647 0.982
SWS (%) 33 ± 6 27 ± 7 12 ± 5 8 ± 4 <0.001 0.163 0.893
REM (%) 2 ± 2 0 ± 0 17 ± 4 8 ± 3 <0.001 0.095 0.217
Movement (%) 8 ± 1 19 ± 5 12 ± 3 20 ± 2 0.237 <0.001 0.582
  • Data are means ± SE. P values were derived from ANOVA, including a repeated-measure factor “hypo” for hypoglycemia vs. control night and “early/late” for early vs. late sleep. Early/late* hypoglycemia denotes the interaction term of both factors.

This Article

  1. Diabetes vol. 56 no. 7 1938-1942