Response to Comment on: Goldstein et al. (2007) Globular Adiponectin Activates Nuclear Factor-κB and Activating Protein-1 and Enhances Angiotensin II–Induced Proliferation in Cardiac Fibroblasts: Diabetes 56:804–808
- 1Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
- 2Department of Medicinal Information, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
- Address correspondence to Yoshiyuki Hattori, MD, Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan. E-mail: yhattori{at}dokkyomed.ac.jp
Goldstein et al. (1) expressed concern that our findings of nuclear factor-κB (NF-κB) activation by the globular domain adiponectin appear to contradict a substantial body of published and ongoing work. We showed that globular adiponectin activates redox-sensitive transcription factors in two different cell types: vascular endothelial cells and cardiac fibroblasts (2,3). These findings do not always contrast with a substantial body of published work. Indeed, a very recent report suggests that adiponectin exerts proinflammatory activities in colon by inducing production of proinflammatory cytokines and inhibiting bioactivity of protective growth factors (4). As initially reported by Ouchi et al. (5), adiponectin suppresses …
