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Table of Contents

August 2007; 56 (8)

Metabolism

    • Filip K. Knop,
    • Tina Vilsbøll,
    • Patricia V. Højberg,
    • Steen Larsen,
    • Sten Madsbad,
    • Aage Vølund,
    • Jens J. Holst,
    • and Thure Krarup

    Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State?

    Diabetes August 2007 56:1951-1959; published ahead of print May 18, 2007, doi:10.2337/db07-0100
    • Maria Kolak,
    • Jukka Westerbacka,
    • Vidya R. Velagapudi,
    • Dick Wågsäter,
    • Laxman Yetukuri,
    • Janne Makkonen,
    • Aila Rissanen,
    • Anna-Maija Häkkinen,
    • Monica Lindell,
    • Robert Bergholm,
    • Anders Hamsten,
    • Per Eriksson,
    • Rachel M. Fisher,
    • Matej Orešic̆,
    • and Hannele Yki-Järvinen

    Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity

    Diabetes August 2007 56:1960-1968; published ahead of print July 9, 2007, doi:10.2337/db07-0111
    • Leonie K. Heilbronn,
    • Søren Gregersen,
    • Deepali Shirkhedkar,
    • Dachun Hu,
    • and Lesley V. Campbell

    Impaired Fat Oxidation After a Single High-Fat Meal in Insulin-Sensitive Nondiabetic Individuals With a Family History of Type 2 Diabetes

    Diabetes August 2007 56:2046-2053; published ahead of print April 24, 2007, doi:10.2337/db06-1687
    • Clinton C. Mason,
    • Robert L. Hanson,
    • and William C. Knowler

    Progression to Type 2 Diabetes Characterized by Moderate Then Rapid Glucose Increases

    Diabetes August 2007 56:2054-2061; published ahead of print May 1, 2007, doi:10.2337/db07-0053
    • Katja S.C. Röckl,
    • Michael F. Hirshman,
    • Josef Brandauer,
    • Nobuharu Fujii,
    • Lee A. Witters,
    • and Laurie J. Goodyear

    Skeletal Muscle Adaptation to Exercise Training: AMP-Activated Protein Kinase Mediates Muscle Fiber Type Shift

    Diabetes August 2007 56:2062-2069; published ahead of print May 18, 2007, doi:10.2337/db07-0255
    • Birgitte Lindegaard,
    • Christian Frøsig,
    • Anne Marie W. Petersen,
    • Peter Plomgaard,
    • Susanne Ditlevsen,
    • Bettina Mittendorfer,
    • Gerrit Van Hall,
    • Jørgen F.P. Wojtaszewski,
    • and Bente K. Pedersen

    Inhibition of Lipolysis Stimulates Peripheral Glucose Uptake but Has No Effect on Endogenous Glucose Production in HIV Lipodystrophy

    Diabetes August 2007 56:2070-2077; published ahead of print June 29, 2007, doi:10.2337/db07-0144
    • Daniel J. Cuthbertson,
    • John A. Babraj,
    • Kirsteen J.W. Mustard,
    • Mhairi C. Towler,
    • Kevin A. Green,
    • Henning Wackerhage,
    • Graeme P. Leese,
    • Keith Baar,
    • Michaela Thomason-Hughes,
    • Calum Sutherland,
    • D. Grahame Hardie,
    • and Michael J. Rennie

    5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men

    Diabetes August 2007 56:2078-2084; published ahead of print May 18, 2007, doi:10.2337/db06-1716
    • Nigel Turner,
    • Clinton R. Bruce,
    • Susan M. Beale,
    • Kyle L. Hoehn,
    • Trina So,
    • Michael S. Rolph,
    • and Gregory J. Cooney

    Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle: Evidence Against a Role for Reduced Fatty Acid Oxidation in Lipid-Induced Insulin Resistance in Rodents

    Diabetes August 2007 56:2085-2092; published ahead of print May 22, 2007, doi:10.2337/db07-0093

Signal Transduction

    • Hua V. Lin,
    • Ja-Young Kim,
    • Alessandro Pocai,
    • Luciano Rossetti,
    • Lawrence Shapiro,
    • Philipp E. Scherer,
    • and Domenico Accili

    Adiponectin Resistance Exacerbates Insulin Resistance in Insulin Receptor Transgenic/Knockout Mice

    Diabetes August 2007 56:1969-1976; published ahead of print May 2, 2007, doi:10.2337/db07-0127
    • Li-Bin Liu,
    • Waka Omata,
    • Itaru Kojima,
    • and Hiroshi Shibata

    The SUMO Conjugating Enzyme Ubc9 is a Regulator of GLUT4 Turnover and Targeting to the Insulin-Responsive Storage Compartment in 3T3-L1 Adipocytes

    Diabetes August 2007 56:1977-1985; published ahead of print May 29, 2007, doi:10.2337/db06-1100
    • Christian Frøsig,
    • Adam J. Rose,
    • Jonas T. Treebak,
    • Bente Kiens,
    • Erik A. Richter,
    • and Jørgen F.P. Wojtaszewski

    Effects of Endurance Exercise Training on Insulin Signaling in Human Skeletal Muscle: Interactions at the Level of Phosphatidylinositol 3-Kinase, Akt, and AS160

    Diabetes August 2007 56:2093-2102; published ahead of print May 18, 2007, doi:10.2337/db06-1698

Obesity Studies

    • Daniela M.L. Tsukumo,
    • Marco A. Carvalho-Filho,
    • José B.C. Carvalheira,
    • Patrícia O. Prada,
    • Sandro M. Hirabara,
    • André A. Schenka,
    • Eliana P. Araújo,
    • José Vassallo,
    • Rui Curi,
    • Lício A. Velloso,
    • and Mario J.A. Saad

    Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

    Diabetes August 2007 56:1986-1998; published ahead of print May 22, 2007, doi:10.2337/db06-1595

Islet Studies

    • Michelle J. Doyle and
    • Lori Sussel

    Nkx2.2 Regulates β-Cell Function in the Mature Islet

    Diabetes August 2007 56:1999-2007; published ahead of print April 24, 2007, doi:10.2337/db06-1766
    • Sanja Cabric,
    • Javier Sanchez,
    • Torbjörn Lundgren,
    • Aksel Foss,
    • Marie Felldin,
    • Ragnar Källen,
    • Kaija Salmela,
    • Annika Tibell,
    • Gunnar Tufveson,
    • Rolf Larsson,
    • Olle Korsgren,
    • and Bo Nilsson

    Islet Surface Heparinization Prevents the Instant Blood-Mediated Inflammatory Reaction in Islet Transplantation

    Diabetes August 2007 56:2008-2015; published ahead of print May 31, 2007, doi:10.2337/db07-0358
    • Chang-jiang Huang,
    • Chia-yu Lin,
    • Leena Haataja,
    • Tatyana Gurlo,
    • Alexandra E. Butler,
    • Robert A. Rizza,
    • and Peter C. Butler

    High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

    Diabetes August 2007 56:2016-2027; published ahead of print May 2, 2007, doi:10.2337/db07-0197
    • Betty Ng,
    • Youhou Kang,
    • Chadwick L. Elias,
    • Yan He,
    • Huanli Xie,
    • John B. Hansen,
    • Philip Wahl,
    • and Herbert Y. Gaisano

    The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1

    Diabetes August 2007 56:2124-2134; published ahead of print May 11, 2007, doi:10.2337/db07-0030

Pathophysiology

    • The Soluble Insulin Receptor Study Group

    Soluble Insulin Receptor Ectodomain Is Elevated in the Plasma of Patients With Diabetes

    Diabetes August 2007 56:2028-2035; published ahead of print June 11, 2007, doi:10.2337/db07-0394
    • Carla J. Gallagher,
    • Carl D. Langefeld,
    • Candace J. Gordon,
    • Joel K. Campbell,
    • Josyf C. Mychalecky,
    • Michael Bryer-Ash,
    • Stephen S. Rich,
    • Donald W. Bowden,
    • and Michèle M. Sale

    Association of the Estrogen Receptor-α Gene With the Metabolic Syndrome and Its Component Traits in African-American Families: The Insulin Resistance Atherosclerosis Family Study

    Diabetes August 2007 56:2135-2141; published ahead of print May 18, 2007, doi:10.2337/db06-1017
    • Frederico G.S. Toledo,
    • Elizabeta V. Menshikova,
    • Vladimir B. Ritov,
    • Koichiro Azuma,
    • Zofia Radikova,
    • James DeLany,
    • and David E. Kelley

    Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes

    Diabetes August 2007 56:2142-2147; published ahead of print May 29, 2007, doi:10.2337/db07-0141

Complications

    • Dae Ryong Cha,
    • Xiaoyan Zhang,
    • Yahua Zhang,
    • Jing Wu,
    • Dongming Su,
    • Jee Young Han,
    • Xuefen Fang,
    • Bo Yu,
    • Matthew D. Breyer,
    • and Youfei Guan

    Peroxisome Proliferator–Activated Receptor α/γ Dual Agonist Tesaglitazar Attenuates Diabetic Nephropathy in db/db Mice

    Diabetes August 2007 56:2036-2045; published ahead of print May 29, 2007, doi:10.2337/db06-1134
    • Cristian Quattrini,
    • Mitra Tavakoli,
    • Maria Jeziorska,
    • Panagiotis Kallinikos,
    • Solomon Tesfaye,
    • Joanne Finnigan,
    • Andrew Marshall,
    • Andrew J.M. Boulton,
    • Nathan Efron,
    • and Rayaz A. Malik

    Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy

    Diabetes August 2007 56:2148-2154; published ahead of print May 18, 2007, doi:10.2337/db07-0285
    • Masao Toyoda,
    • Behzad Najafian,
    • Youngki Kim,
    • M. Luiza Caramori,
    • and Michael Mauer

    Podocyte Detachment and Reduced Glomerular Capillary Endothelial Fenestration in Human Type 1 Diabetic Nephropathy

    Diabetes August 2007 56:2155-2160; published ahead of print May 29, 2007, doi:10.2337/db07-0019

Immunology and Transplantation

    • Hiroki Ishikawa,
    • Hirofumi Ochi,
    • Mei-Ling Chen,
    • Dan Frenkel,
    • Ruth Maron,
    • and Howard L. Weiner

    Inhibition of Autoimmune Diabetes by Oral Administration of Anti-CD3 Monoclonal Antibody

    Diabetes August 2007 56:2103-2109; published ahead of print April 24, 2007, doi:10.2337/db06-1632
    • Amit Goel,
    • Harvey Chiu,
    • Jamie Felton,
    • Jerry P. Palmer,
    • and Barbara Brooks-Worrell

    T-Cell Responses to Islet Antigens Improves Detection of Autoimmune Diabetes and Identifies Patients With More Severe β-Cell Lesions in Phenotypic Type 2 Diabetes

    Diabetes August 2007 56:2110-2115; published ahead of print May 1, 2007, doi:10.2337/db06-0552
    • Chang-Qing Xia,
    • Ruihua Peng,
    • Yushi Qiu,
    • Mani Annamalai,
    • David Gordon,
    • and Michael J. Clare-Salzler

    Transfusion of Apoptotic β-Cells Induces Immune Tolerance to β-Cell Antigens and Prevents Type 1 Diabetes in NOD Mice

    Diabetes August 2007 56:2116-2123; published ahead of print May 11, 2007, doi:10.2337/db06-0825

Genetics

    • Hussam Al-Kateb,
    • Lucia Mirea,
    • Xinlei Xie,
    • Lei Sun,
    • Michelle Liu,
    • Hongtao Chen,
    • Shelley B. Bull,
    • Andrew P. Boright,
    • and Andrew D. Paterson

    Multiple Variants in Vascular Endothelial Growth Factor (VEGFA) Are Risk Factors for Time to Severe Retinopathy in Type 1 Diabetes: The DCCT/EDIC Genetics Study

    Diabetes August 2007 56:2161-2168; published ahead of print May 18, 2007, doi:10.2337/db07-0376

Brief Reports

    • Hanne I. Callewaert,
    • Conny A. Gysemans,
    • Laurence Ladrière,
    • Wannes D'Hertog,
    • Julianna Hagenbrock,
    • Lutgart Overbergh,
    • Decio L. Eizirik,
    • and Chantal Mathieu

    Deletion of STAT-1 Pancreatic Islets Protects Against Streptozotocin-Induced Diabetes and Early Graft Failure but Not Against Late Rejection

    Diabetes August 2007 56:2169-2173; published ahead of print May 1, 2007, doi:10.2337/db07-0052
    • Rita Basu,
    • Utpal B. Pajvani,
    • Robert A. Rizza,
    • and Philipp E. Scherer

    Selective Downregulation of the High–Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes: Differential Regulation From Nondiabetic Subjects

    Diabetes August 2007 56:2174-2177; published ahead of print May 18, 2007, doi:10.2337/db07-0185
    • Ewan R. Pearson,
    • Louise A. Donnelly,
    • Charlotte Kimber,
    • Adrian Whitley,
    • Alex S.F. Doney,
    • Mark I. McCarthy,
    • Andrew T. Hattersley,
    • Andrew D. Morris,
    • and Colin N.A. Palmer

    Variation in TCF7L2 Influences Therapeutic Response to Sulfonylureas: A GoDARTs Study

    Diabetes August 2007 56:2178-2182; published ahead of print May 22, 2007, doi:10.2337/db07-0440

Online Letters to the Editor

    • Gottfried Rudofsky, Jr.,
    • Andreas Schlotterer,
    • Peter P. Nawroth,
    • Angelika Bierhaus,
    • and Andreas Hamann

    Comment on: Lin et al. (2007) SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes: Diabetes 56:1177–1180

    Diabetes August 2007 56:e11; doi:10.2337/db07-0237
    • Shyi-Jang Shin,
    • Hsing-Yi Lin,
    • Chiao-Ling Wang,
    • Pi-Jung Hsiao,
    • and Kun-Der Lin

    Response to Comment on: Lin et al. (2007) SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes: Diabetes 56:1177–1180

    Diabetes August 2007 56:e12-e13; doi:10.2337/db07-0547
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This Issue

August 2007; 56 (8)
  1. Metabolism
  2. Signal Transduction
  3. Obesity Studies
  4. Islet Studies
  5. Pathophysiology
  6. Complications
  7. Immunology and Transplantation
  8. Genetics
  9. Brief Reports
  10. Online Letters to the Editor

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