Comment on: Lin et al. (2007) SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes: Diabetes 56:1177–1180

  1. Gottfried Rudofsky, Jr.,
  2. Andreas Schlotterer,
  3. Peter P. Nawroth,
  4. Angelika Bierhaus and
  5. Andreas Hamann
  1. From the Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
  1. Address correspondence to Andreas Hamann, MD, Division of Endocrinology and Metabolism, Department of Medicine, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany. E-mail: andreas_hamann{at}med.uni-heidelberg.de

Lin et al. (1) have recently reported a positive association of the SUMO4 M55V variant with diabetic nephropathy in an Asian cohort of 430 patients with type 2 diabetes. The authors found a strong association of the G allele with an increased risk for diabetic nephropathy.

Thus far, little is known about the physiologic role of …

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