Table of Contents

Metabolism

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- Carles Cantó,
- Sara Pich,
- José C. Paz,
- Rosario Sanches,
- Vicente Martínez,
- Meritxell Orpinell,
- Manuel Palacín,
- Antonio Zorzano,
- and Anna Gumà
Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells
Diabetes September 2007 56:2185-2193; published ahead of print June 11, 2007, doi:10.2337/db06-1726
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- April C. Inyard,
- Lucy H. Clerk,
- Michelle A. Vincent,
- and Eugene J. Barrett
Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake
Diabetes September 2007 56:2194-2200; published ahead of print June 11, 2007, doi:10.2337/db07-0020
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- Feng Dong,
- Qun Li,
- Nair Sreejayan,
- Jennifer M. Nunn,
- and Jun Ren
Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction: Role of Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and Mitochondrial Biogenesis
Diabetes September 2007 56:2201-2212; published ahead of print June 15, 2007, doi:10.2337/db06-1596
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- Heinz Weinhandl,
- Christoph Pachler,
- Julia K. Mader,
- Dimas Ikeoka,
- Agnes Mautner,
- Andreas Falk,
- Maria Suppan,
- Thomas R. Pieber,
- and Martin Ellmerer
Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans
Diabetes September 2007 56:2213-2217; published ahead of print June 29, 2007, doi:10.2337/db07-0238

Signal Transduction

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- Lisa Logie,
- Antonio J. Ruiz-Alcaraz,
- Michael Keane,
- Yvonne L. Woods,
- Jennifer Bain,
- Rudolfo Marquez,
- Dario R. Alessi,
- and Calum Sutherland
Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells
Diabetes September 2007 56:2218-2227; published ahead of print June 11, 2007, doi:10.2337/db07-0343
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- Grace S. Eng,
- Rachael A. Sheridan,
- Amanda Wyman,
- Maggie M.-Y. Chi,
- Kristin P. Bibee,
- Emily S. Jungheim,
- and Kelle H. Moley
AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations
Diabetes September 2007 56:2228-2234; published ahead of print June 15, 2007, doi:10.2337/db07-0074
Select this article
- Rolf Grempler,
- Darya Zibrova,
- Corinna Schoelch,
- André van Marle,
- Joerg F. Rippmann,
- and Norbert Redemann
Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA^y Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis
Diabetes September 2007 56:2235-2241; published ahead of print June 27, 2007, doi:10.2337/db06-1660

Obesity Studies

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- Karen E. Inouye,
- Hang Shi,
- Jane K. Howard,
- Christine H. Daly,
- Graham M. Lord,
- Barrett J. Rollins,
- and Jeffrey S. Flier
Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue
Diabetes September 2007 56:2242-2250; published ahead of print May 1, 2007, doi:10.2337/db07-0425

Immunology and Transplantation

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- Ruobing Li,
- Nicolas Perez,
- Subha Karumuthil-Melethil,
- and Chenthamarakshan Vasu
Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes
Diabetes September 2007 56:2251-2259; published ahead of print June 27, 2007, doi:10.2337/db07-0502
Select this article
- Chang Yeop Han,
- Savitha Subramanian,
- Christina K. Chan,
- Mohamed Omer,
- Tsuyoshi Chiba,
- Thomas N. Wight,
- and Alan Chait
Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion
Diabetes September 2007 56:2260-2273; published ahead of print June 11, 2007, doi:10.2337/db07-0218
Select this article
- Dongming Su,
- Nan Zhang,
- Jing He,
- Shen Qu,
- Sandra Slusher,
- Rita Bottino,
- Suzanne Bertera,
- Jonathan Bromberg,
- and H. Henry Dong
Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis
Diabetes September 2007 56:2274-2283; published ahead of print June 27, 2007, doi:10.2337/db07-0371

Islet Studies

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- Sílvia Casas,
- Ramon Gomis,
- Fiona M. Gribble,
- Jordi Altirriba,
- Sakari Knuutila,
- and Anna Novials
Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis
Diabetes September 2007 56:2284-2294; published ahead of print June 11, 2007, doi:10.2337/db07-0178
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- Young Lee,
- Mariella Ravazzola,
- Byung-Hyun Park,
- Yuriy K. Bashmakov,
- Lelio Orci,
- and Roger H. Unger
Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic β-Cells in Rats: Role of Lipotoxicity and Prevention by Leptin
Diabetes September 2007 56:2295-2301; published ahead of print June 11, 2007, doi:10.2337/db07-0460
Select this article
- Nicole Liadis,
- Leonardo Salmena,
- Edwin Kwan,
- Panteha Tajmir,
- Stephanie A. Schroer,
- Anna Radziszewska,
- Xie Li,
- Laura Sheu,
- Mohamed Eweida,
- Shilong Xu,
- Herbert Y. Gaisano,
- Razqallah Hakem,
- and Minna Woo
Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models
Diabetes September 2007 56:2302-2311; published ahead of print June 11, 2007, doi:10.2337/db06-1771
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- Aileen J.F. King,
- Justin R. Fernandes,
- Jennifer Hollister-Lock,
- Cameron E. Nienaber,
- Susan Bonner-Weir,
- and Gordon C. Weir
Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation
Diabetes September 2007 56:2312-2318; published ahead of print June 11, 2007, doi:10.2337/db07-0191
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- Katsuya Dezaki,
- Masafumi Kakei,
- and Toshihiko Yada
Ghrelin Uses Gα_i2 and Activates Voltage-Dependent K⁺ Channels to Attenuate Glucose-Induced Ca²⁺ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin
Diabetes September 2007 56:2319-2327; published ahead of print June 15, 2007, doi:10.2337/db07-0345
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- Mingming Hao,
- W. Steven Head,
- Subhadra C. Gunawardana,
- Alyssa H. Hasty,
- and David W. Piston
Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic β-Cell Dysfunction
Diabetes September 2007 56:2328-2338; published ahead of print June 15, 2007, doi:10.2337/db07-0056
Select this article
- Fei-Fei Yan,
- Yu-Wen Lin,
- Courtney MacMullen,
- Arupa Ganguly,
- Charles A. Stanley,
- and Show-Ling Shyng
Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K⁺ Channels: Identification and Rescue
Diabetes September 2007 56:2339-2348; published ahead of print June 15, 2007, doi:10.2337/db07-0150

Pathophysiology

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- Vibe Skov,
- Dorte Glintborg,
- Steen Knudsen,
- Thomas Jensen,
- Torben A. Kruse,
- Qihua Tan,
- Klaus Brusgaard,
- Henning Beck-Nielsen,
- and Kurt Højlund
Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome
Diabetes September 2007 56:2349-2355; published ahead of print June 11, 2007, doi:10.2337/db07-0275
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- Jan A. Ehses,
- Aurel Perren,
- Elisabeth Eppler,
- Pascale Ribaux,
- John A. Pospisilik,
- Ranit Maor-Cahn,
- Xavier Gueripel,
- Helga Ellingsgaard,
- Marten K.J. Schneider,
- Gregoire Biollaz,
- Adriano Fontana,
- Manfred Reinecke,
- Francoise Homo-Delarche,
- and Marc Y. Donath
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
Diabetes September 2007 56:2356-2370; published ahead of print June 19, 2007, doi:10.2337/db06-1650

Complications

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- David J. Friedman,
- Helmut G. Rennke,
- Eva Csizmadia,
- Keiichi Enjyoji,
- and Simon C. Robson
The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy
Diabetes September 2007 56:2371-2379; published ahead of print May 1, 2007, doi:10.2337/db06-1593
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- Deepti Navaratna,
- Paul G. McGuire,
- Gina Menicucci,
- and Arup Das
Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes
Diabetes September 2007 56:2380-2387; published ahead of print May 29, 2007, doi:10.2337/db06-1694

Genetics

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- Joline W.J. Beulens,
- Eric B. Rimm,
- Henk F.J. Hendriks,
- Frank B. Hu,
- JoAnn E. Manson,
- David J. Hunter,
- and Kenneth J. Mukamal
Alcohol Consumption and Type 2 Diabetes: Influence of Genetic Variation in Alcohol Dehydrogenase
Diabetes September 2007 56:2388-2394; published ahead of print June 11, 2007, doi:10.2337/db07-0181

Brief Reports

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- Michelle A. Croce,
- J. Christopher Eagon,
- Lori L. LaRiviere,
- Kevin M. Korenblat,
- Samuel Klein,
- and Brian N. Finck
Hepatic Lipin 1β Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss
Diabetes September 2007 56:2395-2399; published ahead of print June 11, 2007, doi:10.2337/db07-0480
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- Peter In't Veld,
- Dirk Lievens,
- Joeri De Grijse,
- Zhidong Ling,
- Bart Van der Auwera,
- Miriam Pipeleers-Marichal,
- Frans Gorus,
- and Daniel Pipeleers
Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
Diabetes September 2007 56:2400-2404; published ahead of print June 11, 2007, doi:10.2337/db07-0416
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- Erin E. Baschal,
- Theresa A. Aly,
- Sunanda R. Babu,
- Maria S. Fernando,
- Liping Yu,
- Dongmei Miao,
- Katherine J. Barriga,
- Jill M. Norris,
- Janelle A. Noble,
- Henry A. Erlich,
- Marian J. Rewers,
- and George S. Eisenbarth
HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population
Diabetes September 2007 56:2405-2409; published ahead of print May 18, 2007, doi:10.2337/db07-0029
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- Eva Riedl,
- Hannes Koeppel,
- Paul Brinkkoetter,
- Paula Sternik,
- Herbert Steinbeisser,
- Sibylle Sauerhoefer,
- Bart Janssen,
- Fokko J. van der Woude,
- and Benito A. Yard
A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells
Diabetes September 2007 56:2410-2413; published ahead of print June 29, 2007, doi:10.2337/db07-0128

Online Letters to the Editor

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- Paul Trayhurn,
- Bohan Wang,
- and I. Stuart Wood
Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911
Diabetes September 2007 56:e14; doi:10.2337/db07-0747
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- Kazuhiro Takahashi
Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563
Diabetes September 2007 56:e15; doi:10.2337/db07-0592
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- Santiago Rodriguez,
- Tom R. Gaunt,
- Igoř Vorechovský,
- Jana Kralovičová,
- Peter J. Wood,
- and Ian N.M. Day
Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713
Diabetes September 2007 56:e16; doi:10.2337/db07-0805
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- Luc Marchand and
- Constantin Polychronakos
Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713
Diabetes September 2007 56:e17; doi:10.2337/db07-0836

Diabetes

Metabolism

Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells

Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake

Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction: Role of Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and Mitochondrial Biogenesis

Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans

Signal Transduction

Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells

AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations

Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKAy Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis

Obesity Studies

Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

Immunology and Transplantation

Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes

Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion

Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis

Islet Studies

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis

Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic β-Cells in Rats: Role of Lipotoxicity and Prevention by Leptin

Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models

Normal Relationship of β- and Non–β-Cells Not Needed for Successful Islet Transplantation

Ghrelin Uses Gαi2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin

Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic β-Cell Dysfunction

Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K+ Channels: Identification and Rescue

Pathophysiology

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Complications

The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy

Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes

Genetics

Alcohol Consumption and Type 2 Diabetes: Influence of Genetic Variation in Alcohol Dehydrogenase

Brief Reports

Hepatic Lipin 1β Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss

Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population

A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells

Online Letters to the Editor

Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911

Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563

Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

This Issue

Current Issue

Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA^y Mice : SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis

Ghrelin Uses Gα_i2 and Activates Voltage-Dependent K⁺ Channels to Attenuate Glucose-Induced Ca²⁺ Signaling and Insulin Release in Islet β-Cells: Novel Signal Transduction of Ghrelin

Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K⁺ Channels: Identification and Rescue

HLA-DPB10402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB10201/DR4-DQB1*0302 DAISY Population