Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911
- From the Obesity Biology Unit, Division of Metabolic and Cellular Medicine, University Clinical Departments, University of Liverpool, Liverpool, U.K
- Address correspondence to Professor Paul Trayhurn, FRSE, Obesity Biology Unit, Division of Metabolic and Cellular Medicine, University of Liverpool, University Clinical Departments, Duncan Building, Liverpool L69 3GA, U.K. E-mail: p.trayhurn{at}liverpool.ac.uk
We noted with interest the article (1) where evidence for hypoxia in white adipose tissue (WAT) of two mouse models of obesity was presented. This study indicated that the expression of some adipokine genes, including leptin and plasminogen activator inhibitor-1, are increased in WAT of obese animals, that adiponectin is decreased, and that the effects mirrored those in studies on mouse 3T3-L1 cells (1).
These findings are consistent with …
