Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713
- From the Endocrine Genetics Laboratory, McGill Health Center Research Institute, Montréal, Québec, Canada
- Address correspondence to Constantin Polychronakos, MD, Endocrine Genetics Laboratory, McGill Health Center Research Institute, Montréal Children's Hospital, 2300 Tupper St. Ste. C244, H3H 1P3 Montréal, Québec, Canada. E-mail: constantin.polychronakos{at}mcgill.ca
Rodriguez et al. (1) are right in pointing out that our findings (2) do not rule out with absolute certainty a role for rs689 in type 1 diabetes through the effects on splicing under conditions not reflected in the tissues we examined. In biological science, absolute certainty is difficult to attain. …
