Table of Contents

Commentaries

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- Stuart P. Weisberg and
- Rudolph L. Leibel
An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse : Parsing the Supporting Genetic Data
Diabetes January 2008 57:1-2; doi:10.2337/db07-1592
Select this article
- Niels Møller and
- K. Sreekumaran Nair
Diabetes and Protein Metabolism
Diabetes January 2008 57:3-4; doi:10.2337/db07-1581

Metabolism

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- Susanna M. Hofmann,
- Diego Perez-Tilve,
- Todd M. Greer,
- Beth A. Coburn,
- Erin Grant,
- Joshua E. Basford,
- Matthias H. Tschöp,
- and David Y. Hui
Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice
Diabetes January 2008 57:5-12; published ahead of print October 3, 2007, doi:10.2337/db07-0403
Select this article
- Hans P.M. Mortensen Lauritzen,
- Thorkil Ploug,
- Hua Ai,
- Morten Donsmark,
- Clara Prats,
- and Henrik Galbo
Denervation and High-Fat Diet Reduce Insulin Signaling in T-Tubules in Skeletal Muscle of Living Mice
Diabetes January 2008 57:13-23; published ahead of print October 3, 2007, doi:10.2337/db07-0516
Select this article
- Rita Basu,
- Pankaj Shah,
- Ananda Basu,
- Barbara Norby,
- Betty Dicke,
- Visvanathan Chandramouli,
- Ohad Cohen,
- Bernard R. Landau,
- and Robert A. Rizza
Comparison of the Effects of Pioglitazone and Metformin on Hepatic and Extra-Hepatic Insulin Action in People With Type 2 Diabetes
Diabetes January 2008 57:24-31; published ahead of print October 3, 2007, doi:10.2337/db07-0827
Select this article
- Linda R. Peterson,
- Pilar Herrero,
- Janet McGill,
- Kenneth B. Schechtman,
- Zulfia Kisrieva-Ware,
- Donna Lesniak,
- and Robert J. Gropler
Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes
Diabetes January 2008 57:32-40; published ahead of print October 3, 2007, doi:10.2337/db07-1199
Select this article
- Matthew Blatnik,
- Norma Frizzell,
- Suzanne R. Thorpe,
- and John W. Baynes
Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes: Formation of S-(2-Succinyl)Cysteine, a Novel Chemical Modification of Protein and Possible Biomarker of Mitochondrial Stress
Diabetes January 2008 57:41-49; published ahead of print October 12, 2007, doi:10.2337/db07-0838
Select this article
- Gerlies Bock,
- William C. Schumann,
- Rita Basu,
- Shawn C. Burgess,
- Zheng Yan,
- Visvanathan Chandramouli,
- Robert A. Rizza,
- and Bernard R. Landau
Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose: Implications for the Use of ²H₂O to Measure Gluconeogenesis in Humans
Diabetes January 2008 57:50-55; published ahead of print October 12, 2007, doi:10.2337/db07-0694
Select this article
- Sandra Pereira,
- Errol B. Marliss,
- José A. Morais,
- Stéphanie Chevalier,
- and Réjeanne Gougeon
Insulin Resistance of Protein Metabolism in Type 2 Diabetes
Diabetes January 2008 57:56-63; published ahead of print October 16, 2007, doi:10.2337/db07-0887
Select this article
- Min Suk Kim,
- Girish Kewalramani,
- Prasanth Puthanveetil,
- Vivian Lee,
- Ujendra Kumar,
- Ding An,
- Ashraf Abrahani,
- and Brian Rodrigues
Acute Diabetes Moderates Trafficking of Cardiac Lipoprotein Lipase Through p38 Mitogen-Activated Protein Kinase–Dependent Actin Cytoskeleton Organization
Diabetes January 2008 57:64-76; published ahead of print October 17, 2007, doi:10.2337/db07-0832

Signal Transduction

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- Xinyan Huang,
- Raelene A. Charbeneau,
- Ying Fu,
- Kuljeet Kaur,
- Isabelle Gerin,
- Ormond A. MacDougald,
- and Richard R. Neubig
Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele
Diabetes January 2008 57:77-85; published ahead of print October 10, 2007, doi:10.2337/db07-0599

Obesity Studies

Select this article
- Virginie Tolle and
- Malcolm J. Low
In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice
Diabetes January 2008 57:86-94; published ahead of print October 1, 2007, doi:10.2337/db07-0733
Select this article
- Camilla H. Andreasen,
- Kirstine L. Stender-Petersen,
- Mette S. Mogensen,
- Signe S. Torekov,
- Lise Wegner,
- Gitte Andersen,
- Arne L. Nielsen,
- Anders Albrechtsen,
- Knut Borch-Johnsen,
- Signe S. Rasmussen,
- Jesper O. Clausen,
- Annelli Sandbæk,
- Torsten Lauritzen,
- Lars Hansen,
- Torben Jørgensen,
- Oluf Pedersen,
- and Torben Hansen
Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation
Diabetes January 2008 57:95-101; published ahead of print October 17, 2007, doi:10.2337/db07-0910

Immunology and Transplantation

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- Christopher D. Sharp,
- Meng Huang,
- John Glawe,
- D. Ross Patrick,
- Sible Pardue,
- Shayne C. Barlow,
- and Christopher G. Kevil
Stromal Cell–Derived Factor-1/CXCL12 Stimulates Chemorepulsion of NOD/LtJ T-Cell Adhesion to Islet Microvascular Endothelium
Diabetes January 2008 57:102-112; published ahead of print October 1, 2007, doi:10.2337/db07-0494
Select this article
- Michael Tritt,
- Evridiki Sgouroudis,
- Eva d'Hennezel,
- Alexandre Albanese,
- and Ciriaco A. Piccirillo
Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes
Diabetes January 2008 57:113-123; published ahead of print October 10, 2007, doi:10.2337/db06-1700

Islet Studies

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- Kari T. Chambers,
- Julie A. Unverferth,
- Sarah M. Weber,
- Ronald C. Wek,
- Fumihiko Urano,
- and John A. Corbett
The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death
Diabetes January 2008 57:124-132; published ahead of print October 10, 2007, doi:10.2337/db07-0944
Select this article
- Yingda Wang,
- Brian P. Flemming,
- Cyrus C. Martin,
- Shelley R. Allen,
- Jay Walters,
- James K. Oeser,
- John C. Hutton,
- and Richard M. O'Brien
Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo
Diabetes January 2008 57:133-141; published ahead of print October 17, 2007, doi:10.2337/db07-0092
Select this article
- Bjoern A. Menge,
- Andrea Tannapfel,
- Orlin Belyaev,
- Robert Drescher,
- Christophe Müller,
- Waldemar Uhl,
- Wolfgang E. Schmidt,
- and Juris J. Meier
Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell Regeneration
Diabetes January 2008 57:142-149; published ahead of print October 24, 2007, doi:10.2337/db07-1294

Pathophysiology

Select this article
- Ursula Hiden,
- Elisabeth Glitzner,
- Marina Ivanisevic,
- Josip Djelmis,
- Christian Wadsack,
- Uwe Lang,
- and Gernot Desoye
MT1-MMP Expression in First-Trimester Placental Tissue Is Upregulated in Type 1 Diabetes as a Result of Elevated Insulin and Tumor Necrosis Factor-α Levels
Diabetes January 2008 57:150-157; published ahead of print October 10, 2007, doi:10.2337/db07-0903
Select this article
- Jonathan Lu,
- Wei Jiang,
- Jun-Hai Yang,
- Po-Yuan Chang,
- Jeffrey P. Walterscheid,
- Hsin-Hung Chen,
- Marco Marcelli,
- Daming Tang,
- Yuan-Teh Lee,
- Warren S.L. Liao,
- Chao-Yuh Yang,
- and Chu-Huang Chen
Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation
Diabetes January 2008 57:158-166; published ahead of print October 24, 2007, doi:10.2337/db07-1287
Select this article
- Francesco Perticone,
- Raffele Maio,
- Angela Sciacqua,
- Francesco Andreozzi,
- Giuseppina Iemma,
- Maria Perticone,
- Carmine Zoccali,
- and Giorgio Sesti
Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension
Diabetes January 2008 57:167-171; published ahead of print October 10, 2007, doi:10.2337/db07-1189

Complications

Select this article
- Maristela L. Onozato,
- Akihiro Tojo,
- James Leiper,
- Toshiro Fujita,
- Fredrik Palm,
- and Christopher S. Wilcox
Expression of N^G,N^G-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers
Diabetes January 2008 57:172-180; published ahead of print October 1, 2007, doi:10.2337/db06-1772
Select this article
- Eugenia Karamoysoyli,
- Rebecca C. Burnand,
- David R. Tomlinson,
- and Natalie J. Gardiner
Neuritin Mediates Nerve Growth Factor–Induced Axonal Regeneration and Is Deficient in Experimental Diabetic Neuropathy
Diabetes January 2008 57:181-189; published ahead of print October 1, 2007, doi:10.2337/db07-0895

Pharmacology and Therapeutics

Select this article
- Benjamin J. Lamont and
- Daniel J. Drucker
Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice
Diabetes January 2008 57:190-198; published ahead of print October 10, 2007, doi:10.2337/db07-1202

Genetics

Online Letters to the Editor

Select this article
- Simeon Pierre Choukem and
- Jean-François Gautier
Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959
Diabetes January 2008 57:e1; doi:10.2337/db07-1470
Select this article
- Filip K. Knop,
- Tina Vilsbøll,
- Sten Madsbad,
- Thure Krarup,
- and Jens J. Holst
Response to Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959
Diabetes January 2008 57:e2-e3; doi:10.2337/db07-1522

Diabetes

Commentaries

An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse : Parsing the Supporting Genetic Data

Diabetes and Protein Metabolism

Metabolism

Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice

Denervation and High-Fat Diet Reduce Insulin Signaling in T-Tubules in Skeletal Muscle of Living Mice

Comparison of the Effects of Pioglitazone and Metformin on Hepatic and Extra-Hepatic Insulin Action in People With Type 2 Diabetes

Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes

Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes: Formation of S-(2-Succinyl)Cysteine, a Novel Chemical Modification of Protein and Possible Biomarker of Mitochondrial Stress

Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose: Implications for the Use of 2H2O to Measure Gluconeogenesis in Humans

Insulin Resistance of Protein Metabolism in Type 2 Diabetes

Acute Diabetes Moderates Trafficking of Cardiac Lipoprotein Lipase Through p38 Mitogen-Activated Protein Kinase–Dependent Actin Cytoskeleton Organization

Signal Transduction

Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele

Obesity Studies

In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice

Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation

Immunology and Transplantation

Stromal Cell–Derived Factor-1/CXCL12 Stimulates Chemorepulsion of NOD/LtJ T-Cell Adhesion to Islet Microvascular Endothelium

Functional Waning of Naturally Occurring CD4+ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes

Islet Studies

The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death

Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo

Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell Regeneration

Pathophysiology

MT1-MMP Expression in First-Trimester Placental Tissue Is Upregulated in Type 1 Diabetes as a Result of Elevated Insulin and Tumor Necrosis Factor-α Levels

Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation

Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension

Complications

Expression of NG,NG-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers

Neuritin Mediates Nerve Growth Factor–Induced Axonal Regeneration and Is Deficient in Experimental Diabetic Neuropathy

Pharmacology and Therapeutics

Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice

Genetics

Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

Genetic Variants Within the LPIN1 Gene, Encoding Lipin, Are Influencing Phenotypes of the Metabolic Syndrome in Humans

Multiple Superoxide Dismutase 1/Splicing Factor Serine Alanine 15 Variants Are Associated With the Development and Progression of Diabetic Nephropathy: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics Study

Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes

Genome-Wide Scan for Estimated Glomerular Filtration Rate in Multi-Ethnic Diabetic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Mosaic Paternal Uniparental Isodisomy and an ABCC8 Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy

An ABCC8 Gene Mutation and Mosaic Uniparental Isodisomy Resulting in Atypical Diffuse Congenital Hyperinsulinism

Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population

Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor

Online Letters to the Editor

Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

Response to Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

This Issue

Current Issue

Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose: Implications for the Use of ²H₂O to Measure Gluconeogenesis in Humans

Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes

Expression of N^G,N^G-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers