Multiple Superoxide Dismutase 1/Splicing Factor Serine Alanine 15 Variants Are Associated With the Development and Progression of Diabetic Nephropathy

Online-Only Appendix

Files in this Data Supplement:

• OLA21. Figure 21. LDselect for SOD1 SNPs sequenced in PDR90 samples from SeattleSNPs.
• OLA29. Figure of r2 for CEU HapMap samples from Haploview using data from SNPs.
• OLA30. Distributions of Serum SOD1 activity, SOD mass and SOD1 expression in EBV cells by genotype.
• Supplementary Text with Materials and Methods; Supplementary Figure Set Legends
• OLA Supplementary Dataset 1. Variables in univariate Cox PH model without markers.
• OLA Supplementary Dataset 2. Variables in multivariate Cox PH model without markers.
• OLA Supplementary Dataset 3. Descriptive information of 1441 autosomal SNPs genotyped using Illumina technology.
• OLA Supplementary Dataset 4. Association of 1342 autosomal SNPs genotyped using Illumina with categorical and continuous baseline variables.
• OLA Supplementary Dataset 5. Univariate and multivariate Cox PH models association of 1342 autosomal SNPs genotyped using with renal and retinal outcomes.
• OLA Supplementary Dataset 6. Descriptive information of 9 X chromosome SNPs genotyped using Illumina technology.
• OLA Supplementary Dataset 7. Association in Females of 7 X chromosome SNPs genotyped using Illumina with categorical and continuous baseline variables.
• OLA Supplementary Dataset 8. Association in Males of 7 X chromosome SNPs genotyped using Illumina with categorical and continuous baseline variables.
• OLA Supplementary Dataset 9. Univariate and multivariate association of 7 X chromosome SNPs with renal and retinal outcomes.
• OLA Supplementary Dataset 10. Analysis of 62 low minor allele frequency SNPs ( <_1 genotyped="genotyped" using="using" illumina="illumina" with="with" categorical="categorical" and="and" continuous="continuous" baseline="baseline" variables.--="variables.--" end="end" link="link" db071059ola10.xls="db071059ola10.xls" _--="_--">
• OLA Appendix Dataset 11. Analysis of 62 low minor allele frequency SNPs ( <_1 univariate="univariate" and="and" multivariate="multivariate" cox="cox" proportional="proportional" hazards="hazards" association="association" of="of" snps="snps" genotyped="genotyped" using="using" with="with" renal="renal" retinal="retinal" outcomes.--="outcomes.--" end="end" link="link" db071059ola11.xls="db071059ola11.xls" _--="_--">
• OLA Appendix Dataset 12. Analysis of low minor allele frequency SNPs ( <_1 with="with" renal="renal" and="and" retinal="retinal" outcomes="outcomes" using="using" fcmacro.--="fcmacro.--" end="end" link="link" db071059ola12.xls="db071059ola12.xls" _--="_--">
• OLA Supplementary Dataset 13. Descriptive information of additional SOD1 and SFRS15 SNPs genotyped using Taqman technology.
• OLA Supplementary Dataset 14. Descriptive information of additional SOD1 and SFRS15 SNPs genotyped using Taqman technology with categorical and continuous baseline variables.
• OLA Supplementary Dataset 15. Univariate and multivariate Cox PH models association of additional SOD1 and SFRS15 SNPs.
• OLA Table 16. Multi-marker SOD1/SFRS15 selection results
• OLA Table 17. Sequences of primers and probes used for SNP genotyping on Taqman platform
• OLA Table 18 SOD1/SFRS15 sequencing primers
• OLA Table 19. SOD1/SFRS15 sequencing results.
• OLA20 Table 20. World-wide distribution of allele frequencies at 4 SOD1 SNPs.
• OLA22. Non-additivity.
• OLA23. Multivariate models for each of the 3 retinal and 2 renal outcomes without SNPs.
• OLA 24. Renal and retinal status in DCCT/EDIC probands for 1390 white DCCT/EDIC probands, and separately by cohort and treatment.
• OLA 25. Family-based association for SOD1 SNPs with renal outcomes in DCCT/EDIC
• OLA26. Details about the structures of families DCCT/EDIC probands where the relatives have been genotyped at SOD1 SNPs.
• OLA27. SOD1 SNP by DCCT treatment interaction. A SNP-by-treatment interaction term was added to the univariate model for the PM and SN outcomes.
• OLA28. HapMap input format data for Haploview for 6 SOD1/SFRS15 SNPs genotyped by us in CEU HapMap samples.
• OLA31. Statistical analysis of Serum SOD1 activity, SOD mass and SOD1 expression in EBV cells by genotype.