Table of Contents

October 2008; 57 (10)

Perspectives in Diabetes

    • Outi Vaarala,
    • Mark A. Atkinson,
    • and Josef Neu

    The “Perfect Storm” for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

    Diabetes October 2008 57:2555-2562; doi:10.2337/db08-0331

Commentaries

    • Jack L. Leahy

    Mary, Mary, Quite Contrary, How Do Your β-Cells Fail?

    Diabetes October 2008 57:2563-2564; doi:10.2337/db08-0869
    • Robert Scragg

    Vitamin D and Type 2 Diabetes: Are We Ready for a Prevention Trial?

    Diabetes October 2008 57:2565-2566; doi:10.2337/db08-0879
    • Michael D. Walker

    Role of MicroRNA in Pancreatic β-Cells: Where More Is Less

    Diabetes October 2008 57:2567-2568; doi:10.2337/db08-0934

Metabolism

    • J. Antonio González,
    • Lise T. Jensen,
    • Lars Fugger,
    • and Denis Burdakov

    Metabolism-Independent Sugar Sensing in Central Orexin Neurons

    Diabetes October 2008 57:2569-2576; published ahead of print June 30, 2008, doi:10.2337/db08-0548
    • Cendrine Cabou,
    • Gérard Campistron,
    • Nicolas Marsollier,
    • Corinne Leloup,
    • Celine Cruciani-Guglielmacci,
    • Luc Pénicaud,
    • Daniel J. Drucker,
    • Christophe Magnan,
    • and Rémy Burcelin

    Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity

    Diabetes October 2008 57:2577-2587; published ahead of print July 15, 2008, doi:10.2337/db08-0121
    • Natalie Yuen,
    • Steven E. Anderson,
    • Nicole Glaser,
    • Daniel J. Tancredi,
    • and Martha E. O'Donnell

    Cerebral Blood Flow and Cerebral Edema in Rats With Diabetic Ketoacidosis

    Diabetes October 2008 57:2588-2594; published ahead of print July 15, 2008, doi:10.2337/db07-1410
    • Sara M. Reyna,
    • Sangeeta Ghosh,
    • Puntip Tantiwong,
    • C.S. Reddy Meka,
    • Phyllis Eagan,
    • Christopher P. Jenkinson,
    • Eugenio Cersosimo,
    • Ralph A. DeFronzo,
    • Dawn K. Coletta,
    • Apiradee Sriwijitkamol,
    • and Nicolas Musi

    Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

    Diabetes October 2008 57:2595-2602; published ahead of print July 15, 2008, doi:10.2337/db08-0038
    • Claude Knauf,
    • Patrice D. Cani,
    • Dong-Hoon Kim,
    • Miguel A. Iglesias,
    • Chantal Chabo,
    • Aurélie Waget,
    • André Colom,
    • Sophie Rastrelli,
    • Nathalie M. Delzenne,
    • Daniel J. Drucker,
    • Randy J. Seeley,
    • and Remy Burcelin

    Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing

    Diabetes October 2008 57:2603-2612; published ahead of print June 2, 2008, doi:10.2337/db07-1788
    • Beverley Balkau,
    • Leila Mhamdi,
    • Jean-Michel Oppert,
    • John Nolan,
    • Alain Golay,
    • Francesca Porcellati,
    • Markku Laakso,
    • and Ele Ferrannini

    Physical Activity and Insulin Sensitivity: The RISC Study

    Diabetes October 2008 57:2613-2618; published ahead of print June 30, 2008, doi:10.2337/db07-1605

Signal Transduction

    • Nita G. Forouhi,
    • Jian'an Luan,
    • Andrew Cooper,
    • Barbara J. Boucher,
    • and Nicholas J. Wareham

    Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance: The Medical Research Council Ely Prospective Study 1990–2000

    Diabetes October 2008 57:2619-2625; published ahead of print June 30, 2008, doi:10.2337/db08-0593
    • Simona Simone,
    • Yves Gorin,
    • Chakradhar Velagapudi,
    • Hanna E. Abboud,
    • and Samy L. Habib

    Mechanism of Oxidative DNA Damage in Diabetes: Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase

    Diabetes October 2008 57:2626-2636; published ahead of print July 3, 2008, doi:10.2337/db07-1579
    • Laura A. Maile,
    • Byron E. Capps,
    • Emily C. Miller,
    • Ariel W. Aday,
    • and David R. Clemmons

    Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo

    Diabetes October 2008 57:2637-2643; published ahead of print July 15, 2008, doi:10.2337/db08-0326
    • Katsutaro Morino,
    • Susanne Neschen,
    • Stefan Bilz,
    • Saki Sono,
    • Dimitrios Tsirigotis,
    • Richard M. Reznick,
    • Irene Moore,
    • Yoshio Nagai,
    • Varman Samuel,
    • David Sebastian,
    • Morris White,
    • William Philbrick,
    • and Gerald I. Shulman

    Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

    Diabetes October 2008 57:2644-2651; published ahead of print July 15, 2008, doi:10.2337/db06-0454

Obesity Studies

    • Jeremy W. Tomlinson,
    • Joanne Finney,
    • Christopher Gay,
    • Beverly A. Hughes,
    • Susan V. Hughes,
    • and Paul M. Stewart

    Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

    Diabetes October 2008 57:2652-2660; published ahead of print July 15, 2008, doi:10.2337/db08-0495
    • Yuki Nakamura,
    • Keisuke Sanematsu,
    • Rie Ohta,
    • Shinya Shirosaki,
    • Kiyoshi Koyano,
    • Kazuaki Nonaka,
    • Noriatsu Shigemura,
    • and Yuzo Ninomiya

    Diurnal Variation of Human Sweet Taste Recognition Thresholds Is Correlated With Plasma Leptin Levels

    Diabetes October 2008 57:2661-2665; published ahead of print July 15, 2008, doi:10.2337/db07-1103

Immunology and Transplantation

    • Jianming Tan,
    • Shunliang Yang,
    • Jinquan Cai,
    • Junqi Guo,
    • Lianghu Huang,
    • Zhixian Wu,
    • Jin Chen,
    • and Lianming Liao

    Simultaneous Islet and Kidney Transplantation in Seven Patients With Type 1 Diabetes and End-Stage Renal Disease Using a Glucocorticoid-Free Immunosuppressive Regimen With Alemtuzumab Induction

    Diabetes October 2008 57:2666-2671; published ahead of print July 15, 2008, doi:10.2337/db08-0358
    • Mark R. Rigby,
    • Alison M. Trexler,
    • Thomas C. Pearson,
    • and Christian P. Larsen

    CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion

    Diabetes October 2008 57:2672-2683; published ahead of print May 20, 2008, doi:10.2337/db07-1712
    • Christophe M. Filippi,
    • Amy E. Juedes,
    • Janine E. Oldham,
    • Ellie Ling,
    • Lisa Togher,
    • Yufeng Peng,
    • Richard A. Flavell,
    • and Matthias G. von Herrath

    Transforming Growth Factor-β Suppresses the Activation of CD8+ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity

    Diabetes October 2008 57:2684-2692; published ahead of print August 8, 2008, doi:10.2337/db08-0609
    • Janet M. Wenzlau,
    • Yu Liu,
    • Liping Yu,
    • Ong Moua,
    • Kimberly T. Fowler,
    • Sampathkumar Rangasamy,
    • Jay Walters,
    • George S. Eisenbarth,
    • Howard W. Davidson,
    • and John C. Hutton

    A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes

    Diabetes October 2008 57:2693-2697; published ahead of print June 30, 2008, doi:10.2337/db08-0522

Islet Studies

    • Manu V. Chakravarthy,
    • Yimin Zhu,
    • Mitchell B. Wice,
    • Trey Coleman,
    • Kirk L. Pappan,
    • Connie A. Marshall,
    • Michael L. McDaniel,
    • and Clay F. Semenkovich

    Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age

    Diabetes October 2008 57:2698-2707; published ahead of print June 30, 2008, doi:10.2337/db08-0404
    • Abdelfattah El Ouaamari,
    • Nadine Baroukh,
    • Geert A. Martens,
    • Patricia Lebrun,
    • Daniel Pipeleers,
    • and Emmanuel van Obberghen

    miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells

    Diabetes October 2008 57:2708-2717; published ahead of print June 30, 2008, doi:10.2337/db07-1614
    • Yuying Jiang,
    • Wataru Nishimura,
    • Deborah Devor-Henneman,
    • Donna Kusewitt,
    • Haijuan Wang,
    • Michael P. Holloway,
    • Takehiko Dohi,
    • Edmond Sabo,
    • Michael L. Robinson,
    • Dario C. Altieri,
    • Arun Sharma,
    • and Rachel A. Altura

    Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin

    Diabetes October 2008 57:2718-2727; published ahead of print July 3, 2008, doi:10.2337/db08-0170
    • Pascal Lovis,
    • Elodie Roggli,
    • D. Ross Laybutt,
    • Sonia Gattesco,
    • Jiang-Yan Yang,
    • Christian Widmann,
    • Amar Abderrahmani,
    • and Romano Regazzi

    Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

    Diabetes October 2008 57:2728-2736; published ahead of print July 15, 2008, doi:10.2337/db07-1252
    • Winifred P.S. Wong,
    • David W. Scott,
    • Chia-Lin Chuang,
    • Shaoping Zhang,
    • Hong Liu,
    • Athena Ferreira,
    • Etuate L. Saafi,
    • Yee Soon Choong,
    • and Garth J.S. Cooper

    Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance

    Diabetes October 2008 57:2737-2744; published ahead of print July 15, 2008, doi:10.2337/db06-1755
    • Nathalie M. Fiaschi-Taesch,
    • Dora M. Berman,
    • Brian M. Sicari,
    • Karen K. Takane,
    • Adolfo Garcia-Ocaña,
    • Camillo Ricordi,
    • Norma S. Kenyon,
    • and Andrew F. Stewart

    Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets

    Diabetes October 2008 57:2745-2754; published ahead of print July 15, 2008, doi:10.2337/db07-1085
    • Kirstine Juhl,
    • Suparna A. Sarkar,
    • Randall Wong,
    • Jan Jensen,
    • and John C. Hutton

    Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

    Diabetes October 2008 57:2755-2761; published ahead of print July 3, 2008, doi:10.2337/db07-1126

Pathophysiology

    • Norbert Stefan,
    • Andreas Fritsche,
    • Cornelia Weikert,
    • Heiner Boeing,
    • Hans-Georg Joost,
    • Hans-Ulrich Häring,
    • and Matthias B. Schulze

    Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes

    Diabetes October 2008 57:2762-2767; published ahead of print July 15, 2008, doi:10.2337/db08-0538
    • Roos C. Padmos,
    • Nanette C. Schloot,
    • Huriya Beyan,
    • Cindy Ruwhof,
    • Frank J.T. Staal,
    • Dick de Ridder,
    • Henk-Jan Aanstoot,
    • Wai Kwan Lam-Tse,
    • Harm de Wit,
    • Christian de Herder,
    • Roos C. Drexhage,
    • Barbara Menart,
    • R. David Leslie,
    • Hemmo A. Drexhage,
    • and the LADA Consortium

    Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes

    Diabetes October 2008 57:2768-2773; published ahead of print July 3, 2008, doi:10.2337/db08-0496

Complications

    • Nino Mzhavia,
    • Shuiqing Yu,
    • Shota Ikeda,
    • Tehua T. Chu,
    • Ira Goldberg,
    • and Hayes M. Dansky

    Neuronatin: A New Inflammation Gene Expressed on the Aortic Endothelium of Diabetic Mice

    Diabetes October 2008 57:2774-2783; published ahead of print June 30, 2008, doi:10.2337/db07-1746
    • Shuhei Kawahara,
    • Yasuaki Hata,
    • Takeshi Kita,
    • Ryoichi Arita,
    • Muneki Miura,
    • Shintaro Nakao,
    • Yasutaka Mochizuki,
    • Hiroshi Enaida,
    • Tadahisa Kagimoto,
    • Yoshinobu Goto,
    • Ali Hafezi-Moghadam,
    • and Tatsuro Ishibashi

    Potent Inhibition of Cicatricial Contraction in Proliferative Vitreoretinal Diseases by Statins

    Diabetes October 2008 57:2784-2793; published ahead of print July 3, 2008, doi:10.2337/db08-0302
    • Rabea Asleh,
    • Shany Blum,
    • Shiri Kalet-Litman,
    • Jonia Alshiek,
    • Rachel Miller-Lotan,
    • Roy Asaf,
    • Wasseem Rock,
    • Michael Aviram,
    • Uzi Milman,
    • Chen Shapira,
    • Zaid Abassi,
    • and Andrew P. Levy

    Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 Genotype

    Diabetes October 2008 57:2794-2800; published ahead of print July 3, 2008, doi:10.2337/db08-0450
    • Liliana N. Berti-Mattera,
    • Timothy S. Kern,
    • Ruth E. Siegel,
    • Ina Nemet,
    • and Rochanda Mitchell

    Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats

    Diabetes October 2008 57:2801-2808; published ahead of print July 15, 2008, doi:10.2337/db07-1274
    • Mingzhan Xue,
    • Qingwen Qian,
    • Antonysunil Adaikalakoteswari,
    • Naila Rabbani,
    • Roya Babaei-Jadidi,
    • and Paul J. Thornalley

    Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease

    Diabetes October 2008 57:2809-2817; published ahead of print July 15, 2008, doi:10.2337/db06-1003
    • Jolanda M. van Golde,
    • Matthijs S. Ruiter,
    • Nicolaas C. Schaper,
    • Stefan Vöö,
    • Johannes Waltenberger,
    • Walter H. Backes,
    • Mark J. Post,
    • and Maya S. Huijberts

    Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes

    Diabetes October 2008 57:2818-2823; published ahead of print July 15, 2008, doi:10.2337/db08-0229
    • Ching-Hsin Ku,
    • Kathryn E. White,
    • Alessandra Dei Cas,
    • Anthea Hayward,
    • Zoe Webster,
    • Rudy Bilous,
    • Sally Marshall,
    • Giancarlo Viberti,
    • and Luigi Gnudi

    Inducible Overexpression of sFlt-1 in Podocytes Ameliorates Glomerulopathy in Diabetic Mice

    Diabetes October 2008 57:2824-2833; published ahead of print July 22, 2008, doi:10.2337/db08-0647

Genetics

    • Ying Wu,
    • Huaixing Li,
    • Ruth J.F. Loos,
    • Zhijie Yu,
    • Xingwang Ye,
    • Lihua Chen,
    • An Pan,
    • Frank B. Hu,
    • and Xu Lin

    Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population

    Diabetes October 2008 57:2834-2842; published ahead of print July 15, 2008, doi:10.2337/db08-0047
    • David-Alexandre Trégouet,
    • Per-Henrik Groop,
    • Steven McGinn,
    • Carol Forsblom,
    • Samy Hadjadj,
    • Michel Marre,
    • Hans-Henrik Parving,
    • Lise Tarnow,
    • Ralph Telgmann,
    • Tiphaine Godefroy,
    • Viviane Nicaud,
    • Rachel Rousseau,
    • Maikki Parkkonen,
    • Anna Hoverfält,
    • Ivo Gut,
    • Simon Heath,
    • Fumihiko Matsuda,
    • Roger Cox,
    • Gbenga Kazeem,
    • Martin Farrall,
    • Dominique Gauguier,
    • Stefan-Martin Brand-Herrmann,
    • François Cambien,
    • Mark Lathrop,
    • and Nathalie Vionnet

    G/T Substitution in Intron 1 of the UNC13B Gene Is Associated With Increased Risk of Nephropathy in Patients With Type 1 Diabetes

    Diabetes October 2008 57:2843-2850; published ahead of print July 15, 2008, doi:10.2337/db08-0073
    • Jonathan T. Tan,
    • Rajkumar Dorajoo,
    • Mark Seielstad,
    • Xue Ling Sim,
    • Rick Twee-Hee Ong,
    • Kee Seng Chia,
    • Tien Yin Wong,
    • Seang Mei Saw,
    • Suok Kai Chew,
    • Tin Aung,
    • and E-Shyong Tai

    FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore

    Diabetes October 2008 57:2851-2857; published ahead of print July 3, 2008, doi:10.2337/db08-0214
    • Patrick Concannon,
    • Suna Onengut-Gumuscu,
    • John A. Todd,
    • Deborah J. Smyth,
    • Flemming Pociot,
    • Regine Bergholdt,
    • Beena Akolkar,
    • Henry A. Erlich,
    • Joan E. Hilner,
    • Cécile Julier,
    • Grant Morahan,
    • Jørn Nerup,
    • Concepcion R. Nierras,
    • Wei-Min Chen,
    • Stephen S. Rich,
    • and the Type 1 Diabetes Genetics Consortium

    A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

    Diabetes October 2008 57:2858-2861; published ahead of print July 22, 2008, doi:10.2337/db08-0753
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This Issue

October 2008; 57 (10)
  1. Perspectives in Diabetes
  2. Commentaries
  3. Metabolism
  4. Signal Transduction
  5. Obesity Studies
  6. Immunology and Transplantation
  7. Islet Studies
  8. Pathophysiology
  9. Complications
  10. Genetics

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