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Table of Contents

November 2008; 57 (11)

Perspectives in Diabetes

    • Christophe M. Filippi and
    • Matthias G. von Herrath

    Viral Trigger for Type 1 Diabetes: Pros and Cons

    Diabetes November 2008 57:2863-2871; doi:10.2337/db07-1023
    • Massimo Pietropaolo,
    • Julie M. Surhigh,
    • Patrick W. Nelson,
    • and George S. Eisenbarth

    Primer: Immunity and Autoimmunity

    Diabetes November 2008 57:2872-2882; doi:10.2337/db07-1691
    • Eitan Akirav,
    • Jake A. Kushner,
    • and Kevan C. Herold

    β-Cell Mass and Type 1 Diabetes: Going, Going, Gone?

    Diabetes November 2008 57:2883-2888; doi:10.2337/db07-1817
    • Mark I. McCarthy and
    • Andrew T. Hattersley

    Learning From Molecular Genetics: Novel Insights Arising From the Definition of Genes for Monogenic and Type 2 Diabetes

    Diabetes November 2008 57:2889-2898; doi:10.2337/db08-0343
    • Susan Bonner-Weir and
    • Timothy D. O'Brien

    Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner

    Diabetes November 2008 57:2899-2904; doi:10.2337/db07-1842
    • Stephen O'Rahilly and
    • I. Sadaf Farooqi

    Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions

    Diabetes November 2008 57:2905-2910; doi:10.2337/db08-0210

Commentaries

    • Muin J. Khoury,
    • Rodolfo Valdez,
    • and Ann Albright

    Public Health Genomics Approach to Type 2 Diabetes

    Diabetes November 2008 57:2911-2914; doi:10.2337/db08-1045
    • Stephen S. Rich,
    • Jill M. Norris,
    • and Jerome I. Rotter

    Genes Associated With Risk of Type 2 Diabetes Identified by a Candidate-Wide Association Scan: As a Trickle Becomes a Flood

    Diabetes November 2008 57:2915-2917; doi:10.2337/db08-0941
    • Stephen O'Rahilly,
    • Gordon C. Weir,
    • and David R. Matthews

    An Appreciation of Robert Turner

    Diabetes November 2008 57:2918-2921; doi:10.2337/db07-1644
    • Li-Jun Yang

    Big Mac Attack: Does It Play a Direct Role for Monocytes/Macrophages in Type 1 Diabetes?

    Diabetes November 2008 57:2922-2923; doi:10.2337/db08-1007

Metabolism

    • Heiko Bugger,
    • Sihem Boudina,
    • Xiao Xuan Hu,
    • Joseph Tuinei,
    • Vlad G. Zaha,
    • Heather A. Theobald,
    • Ui Jeong Yun,
    • Alfred P. McQueen,
    • Benjamin Wayment,
    • Sheldon E. Litwin,
    • and E. Dale Abel

    Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

    Diabetes November 2008 57:2924-2932; published ahead of print August 4, 2008, doi:10.2337/db08-0079
    • Ian R. Lanza,
    • Daniel K. Short,
    • Kevin R. Short,
    • Sreekumar Raghavakaimal,
    • Rita Basu,
    • Michael J. Joyner,
    • Joseph P. McConnell,
    • and K. Sreekumaran Nair

    Endurance Exercise as a Countermeasure for Aging

    Diabetes November 2008 57:2933-2942; published ahead of print August 20, 2008, doi:10.2337/db08-0349
    • Esther Phielix,
    • Vera B. Schrauwen-Hinderling,
    • Marco Mensink,
    • Ellen Lenaers,
    • Ruth Meex,
    • Joris Hoeks,
    • Marianne Eline Kooi,
    • Esther Moonen-Kornips,
    • Jean-Pierre Sels,
    • Matthijs K.C. Hesselink,
    • and Patrick Schrauwen

    Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

    Diabetes November 2008 57:2943-2949; published ahead of print August 4, 2008, doi:10.2337/db08-0391
    • Bernhard O. Boehm,
    • Peter Möller,
    • Josef Högel,
    • Bernhard R. Winkelmann,
    • Wilfried Renner,
    • Silke Rosinger,
    • Ursula Seelhorst,
    • Britta Wellnitz,
    • Winfried März,
    • Julia Melzner,
    • and Silke Brüderlein

    Lymphocytes of Type 2 Diabetic Women Carry a High Load of Stable Chromosomal Aberrations: A Novel Risk Factor for Disease-Related Early Death

    Diabetes November 2008 57:2950-2957; published ahead of print July 23, 2008, doi:10.2337/db08-0274
    • Nobuharu Fujii,
    • Richard C. Ho,
    • Yasuko Manabe,
    • Niels Jessen,
    • Taro Toyoda,
    • William L. Holland,
    • Scott A. Summers,
    • Michael F. Hirshman,
    • and Laurie J. Goodyear

    Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice

    Diabetes November 2008 57:2958-2966; published ahead of print August 26, 2008, doi:10.2337/db07-1187

Signal Transduction

    • Takafumi Senokuchi,
    • Chien-Ping Liang,
    • Tracie A. Seimon,
    • Seongah Han,
    • Michihiro Matsumoto,
    • Alexander S. Banks,
    • Ji-Hye Paik,
    • Ronald A. DePinho,
    • Domenico Accili,
    • Ira Tabas,
    • and Alan R. Tall

    Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress

    Diabetes November 2008 57:2967-2976; published ahead of print August 26, 2008, doi:10.2337/db08-0520

Obesity Studies

    • Ruben Nogueiras,
    • Christelle Veyrat-Durebex,
    • Paula M. Suchanek,
    • Marcella Klein,
    • Johannes Tschöp,
    • Charles Caldwell,
    • Stephen C. Woods,
    • Gabor Wittmann,
    • Masahiko Watanabe,
    • Zsolt Liposits,
    • Csaba Fekete,
    • Ofer Reizes,
    • Francoise Rohner-Jeanrenaud,
    • and Matthias H. Tschöp

    Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats

    Diabetes November 2008 57:2977-2991; published ahead of print August 20, 2008, doi:10.2337/db08-0161
    • Doris Joy Espiritu and
    • Theodore Mazzone

    Oxidative Stress Regulates Adipocyte Apolipoprotein E and Suppresses Its Expression in Obesity

    Diabetes November 2008 57:2992-2998; published ahead of print August 4, 2008, doi:10.2337/db08-0592
    • Hong Lan,
    • Lizbeth M. Hoos,
    • Li Liu,
    • Glen Tetzloff,
    • Weiwen Hu,
    • Susan J. Abbondanzo,
    • Galya Vassileva,
    • Eric L. Gustafson,
    • Joseph A. Hedrick,
    • and Harry R. Davis

    Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease

    Diabetes November 2008 57:2999-3006; published ahead of print August 4, 2008, doi:10.2337/db08-0596
    • Michael I. Goran,
    • Christianne Lane,
    • Claudia Toledo-Corral,
    • and Marc J. Weigensberg

    Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children: Association With Progressive Insulin Resistance, Poor β-Cell Function, and Increasing Visceral Fat

    Diabetes November 2008 57:3007-3012; published ahead of print August 4, 2008, doi:10.2337/db08-0445

Immunology and Transplantation

    • Paolo Fiorina,
    • Andrea Vergani,
    • Shirine Dada,
    • Mollie Jurewicz,
    • Masie Wong,
    • Kenneth Law,
    • Erxi Wu,
    • Ze Tian,
    • Reza Abdi,
    • Indira Guleria,
    • Scott Rodig,
    • Kyri Dunussi-Joannopoulos,
    • Jeffrey Bluestone,
    • and Mohamed H. Sayegh

    Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

    Diabetes November 2008 57:3013-3024; published ahead of print August 8, 2008, doi:10.2337/db08-0420
    • Andrea P. Martin,
    • Sara Rankin,
    • Simon Pitchford,
    • Israel F. Charo,
    • Glaucia C. Furtado,
    • and Sergio A. Lira

    Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

    Diabetes November 2008 57:3025-3033; published ahead of print July 15, 2008, doi:10.2337/db08-0625

Islet Studies

    • Mia C. Åkerfeldt,
    • Jennifer Howes,
    • Jeng Yie Chan,
    • Veronica A. Stevens,
    • Nacer Boubenna,
    • Helen M. McGuire,
    • Cecile King,
    • Trevor J. Biden,
    • and D. Ross Laybutt

    Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

    Diabetes November 2008 57:3034-3044; published ahead of print June 30, 2008, doi:10.2337/db07-1802
    • Lucy Marzban,
    • Alejandra Tomas,
    • Thomas C. Becker,
    • Lawrence Rosenberg,
    • Jose Oberholzer,
    • Paul E. Fraser,
    • Philippe A. Halban,
    • and C. Bruce Verchere

    Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

    Diabetes November 2008 57:3045-3055; published ahead of print August 11, 2008, doi:10.2337/db08-0485
    • Irene Cozar-Castellano,
    • George Harb,
    • Karen Selk,
    • Karen Takane,
    • Rupangi Vasavada,
    • Brian Sicari,
    • Brian Law,
    • Pili Zhang,
    • Donald K. Scott,
    • Nathalie Fiaschi-Taesch,
    • and Andrew F. Stewart

    Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

    Diabetes November 2008 57:3056-3068; published ahead of print July 23, 2008, doi:10.2337/db08-0393
    • Amanda Ackermann Misfeldt,
    • Robert H. Costa,
    • and Maureen Gannon

    β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1

    Diabetes November 2008 57:3069-3077; published ahead of print August 26, 2008, doi:10.2337/db08-0878

Pathophysiology

    • Anders R. Nielsen,
    • Christian Erikstrup,
    • Julia S. Johansen,
    • Christian P. Fischer,
    • Peter Plomgaard,
    • Rikke Krogh-Madsen,
    • Sarah Taudorf,
    • Birgitte Lindegaard,
    • and Bente K. Pedersen

    Plasma YKL-40: A BMI-Independent Marker of Type 2 Diabetes

    Diabetes November 2008 57:3078-3082; published ahead of print July 23, 2008, doi:10.2337/db08-0182

Complications

    • Christopher T. Kodl,
    • Daniel T. Franc,
    • Jyothi P. Rao,
    • Fiona S. Anderson,
    • William Thomas,
    • Bryon A. Mueller,
    • Kelvin O. Lim,
    • and Elizabeth R. Seaquist

    Diffusion Tensor Imaging Identifies Deficits in White Matter Microstructure in Subjects With Type 1 Diabetes That Correlate With Reduced Neurocognitive Function

    Diabetes November 2008 57:3083-3089; published ahead of print August 11, 2008, doi:10.2337/db08-0724
    • Mohan R. Dasu,
    • Sridevi Devaraj,
    • Ling Zhao,
    • Daniel H. Hwang,
    • and Ishwarlal Jialal

    High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

    Diabetes November 2008 57:3090-3098; published ahead of print July 23, 2008, doi:10.2337/db08-0564
    • Taiga Shibata,
    • Keiko Naruse,
    • Hideki Kamiya,
    • Mika Kozakae,
    • Masaki Kondo,
    • Yutaka Yasuda,
    • Nobuhisa Nakamura,
    • Kimiko Ota,
    • Takahiro Tosaki,
    • Takashi Matsuki,
    • Eitaro Nakashima,
    • Yoji Hamada,
    • Yutaka Oiso,
    • and Jiro Nakamura

    Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats

    Diabetes November 2008 57:3099-3107; published ahead of print August 26, 2008, doi:10.2337/db08-0031
    • Duk-Hee Lee,
    • David R. Jacobs, Jr.,
    • and Michael Steffes

    Association of Organochlorine Pesticides with Peripheral Neuropathy in Patients with Diabetes or Impaired Fasting Glucose

    Diabetes November 2008 57:3108-3111; published ahead of print July 22, 2008, doi:10.2337/db08-0668

Genetics

    • Marju Orho-Melander,
    • Olle Melander,
    • Candace Guiducci,
    • Pablo Perez-Martinez,
    • Dolores Corella,
    • Charlotta Roos,
    • Ryan Tewhey,
    • Mark J. Rieder,
    • Jennifer Hall,
    • Goncalo Abecasis,
    • E. Shyong Tai,
    • Cullan Welch,
    • Donna K. Arnett,
    • Valeriya Lyssenko,
    • Eero Lindholm,
    • Richa Saxena,
    • Paul I.W. de Bakker,
    • Noel Burtt,
    • Benjamin F. Voight,
    • Joel N. Hirschhorn,
    • Katherine L. Tucker,
    • Thomas Hedner,
    • Tiinamaija Tuomi,
    • Bo Isomaa,
    • Karl-Fredrik Eriksson,
    • Marja-Riitta Taskinen,
    • Björn Wahlstrand,
    • Thomas E. Hughes,
    • Laurence D. Parnell,
    • Chao-Qiang Lai,
    • Göran Berglund,
    • Leena Peltonen,
    • Erkki Vartiainen,
    • Pekka Jousilahti,
    • Aki S. Havulinna,
    • Veikko Salomaa,
    • Peter Nilsson,
    • Leif Groop,
    • David Altshuler,
    • Jose M. Ordovas,
    • and Sekar Kathiresan

    Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

    Diabetes November 2008 57:3112-3121; published ahead of print August 4, 2008, doi:10.2337/db08-0516
    • Mandy van Hoek,
    • Abbas Dehghan,
    • Jacqueline C.M. Witteman,
    • Cornelia M. van Duijn,
    • André G. Uitterlinden,
    • Ben A. Oostra,
    • Albert Hofman,
    • Eric J.G. Sijbrands,
    • and A. Cecile J.W. Janssens

    Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies: A Population-Based Study

    Diabetes November 2008 57:3122-3128; published ahead of print August 11, 2008, doi:10.2337/db08-0425
    • Hana Lango,
    • Colin N.A. Palmer,
    • Andrew D. Morris,
    • Eleftheria Zeggini,
    • Andrew T. Hattersley,
    • Mark I. McCarthy,
    • Timothy M. Frayling,
    • and Michael N. Weedon

    Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

    Diabetes November 2008 57:3129-3135; published ahead of print June 30, 2008, doi:10.2337/db08-0504
    • Kyle J. Gaulton,
    • Cristen J. Willer,
    • Yun Li,
    • Laura J. Scott,
    • Karen N. Conneely,
    • Anne U. Jackson,
    • William L. Duren,
    • Peter S. Chines,
    • Narisu Narisu,
    • Lori L. Bonnycastle,
    • Jingchun Luo,
    • Maurine Tong,
    • Andrew G. Sprau,
    • Elizabeth W. Pugh,
    • Kimberly F. Doheny,
    • Timo T. Valle,
    • Gonçalo R. Abecasis,
    • Jaakko Tuomilehto,
    • Richard N. Bergman,
    • Francis S. Collins,
    • Michael Boehnke,
    • and Karen L. Mohlke

    Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes

    Diabetes November 2008 57:3136-3144; published ahead of print August 4, 2008, doi:10.2337/db07-1731
    • Lu Qi,
    • Kihwa Kang,
    • Cuilin Zhang,
    • Rob M. van Dam,
    • Peter Kraft,
    • David Hunter,
    • Chih-Hao Lee,
    • and Frank B. Hu

    Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test

    Diabetes November 2008 57:3145-3151; published ahead of print July 22, 2008, doi:10.2337/db08-0006
    • Jennifer M. Barker,
    • Taylor M. Triolo,
    • Theresa A. Aly,
    • Erin E. Baschal,
    • Sunanda R. Babu,
    • Adam Kretowski,
    • Marian J. Rewers,
    • and George S. Eisenbarth

    Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Potential for Rapid Screening

    Diabetes November 2008 57:3152-3155; published ahead of print August 11, 2008, doi:10.2337/db08-0605
    • Lijun Ma,
    • Robert L. Hanson,
    • Lorem N. Que,
    • Yan Guo,
    • Sayuko Kobes,
    • Clifton Bogardus,
    • and Leslie J. Baier

    PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians

    Diabetes November 2008 57:3156-3160; published ahead of print July 22, 2008, doi:10.2337/db07-1800
    • Inês Barroso,
    • Jian’an Luan,
    • Eleanor Wheeler,
    • Pamela Whittaker,
    • Jon Wasson,
    • Eleftheria Zeggini,
    • Michael N. Weedon,
    • Sarah Hunt,
    • Ranganath Venkatesh,
    • Timothy M. Frayling,
    • Marcos Delgado,
    • Rosalind J. Neuman,
    • Jinghua Zhao,
    • Richard Sherva,
    • Benjamin Glaser,
    • Mark Walker,
    • Graham Hitman,
    • Mark I. McCarthy,
    • Andrew T. Hattersley,
    • M. Alan Permutt,
    • Nicholas J. Wareham,
    • and Panagiotis Deloukas

    Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants: A Lesson for Replication Studies

    Diabetes November 2008 57:3161-3165; published ahead of print August 26, 2008, doi:10.2337/db08-0719

Erratum

  • Erratum

    Diabetes November 2008 57:3166; doi:10.2337/db08-er11

Online Letters to the Editor

    • Maria Rita Negrão,
    • Rosário Monteiro,
    • Conceição Calhau,
    • Raquel Soares,
    • and Isabel Azevedo

    Comment on: Hosogai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation. Diabetes 56:901–911, 2007

    Diabetes November 2008 57:e15; doi:10.2337/db08-0603
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This Issue

November 2008; 57 (11)
  1. Perspectives in Diabetes
  2. Commentaries
  3. Metabolism
  4. Signal Transduction
  5. Obesity Studies
  6. Immunology and Transplantation
  7. Islet Studies
  8. Pathophysiology
  9. Complications
  10. Genetics
  11. Erratum
  12. Online Letters to the Editor

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