Comment on: Hosogai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation. Diabetes 56:901–911, 2007
- From the Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal
- Corresponding author: Isabel Azevedo, isabelaz{at}med.up.pt
In their most opportune and valuable article (1), Hosogai et al. provide a clear and quite extensive concatenation of data that indicate a very important role for hypoperfusion and hypoxia of adipose tissue in the dysregulated production of adipocytokines and metabolic syndrome. We had previously published a study on the role of adipocyte rupture—the more facile the bigger the adipocyte—in the inflammatory process …
