Comment on: Hosogai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation. Diabetes 56:901–911, 2007

  1. Maria Rita Negrão,
  2. Rosário Monteiro,
  3. Conceição Calhau,
  4. Raquel Soares and
  5. Isabel Azevedo
  1. From the Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal
  1. Corresponding author: Isabel Azevedo, isabelaz{at}

In their most opportune and valuable article (1), Hosogai et al. provide a clear and quite extensive concatenation of data that indicate a very important role for hypoperfusion and hypoxia of adipose tissue in the dysregulated production of adipocytokines and metabolic syndrome. We had previously published a study on the role of adipocyte rupture—the more facile the bigger the adipocyte—in the inflammatory process …

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