Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008
- 1Kidney Center, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands
- 2Steno Diabetes Center, Gentofte, Denmark
- Corresponding author: Stephan J.L. Bakker, s.j.l.bakker{at}int.umcg.nl
We read with interest the article by Wanic et al. (1) in which they present the first prospective data on polymorphisms in carnosinase genes and progression of diabetic nephropathy in diabetic patients. Prior studies, in which a polymorphism in carnosinase gene CNDP1 was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes (2–4). At variance with …
