Response to Comment on: Wanic et al. (2008) Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes: Results of Large Case-Control and Follow-Up Studies: Diabetes 57:2547–2551, 2008
- 1Research Division, Joslin Diabetes Center, Boston, Massachusetts
- 2Department of Medicine, Harvard Medical School, Boston, Massachusetts
- Corresponding author: Andrzej S. Krolewski, andrzej.krolewski{at}joslin.harvard.edu
We thank Bakker et al. (1) for their concern about the factors affecting risk of end-stage renal disease (ESRD) and their appreciation of the issues relating to survival bias. In the original report (2), the Cox proportional hazards regression model of ESRD risk according to carnosinase genotype was adjusted for sex, duration of diabetes, age at examination, age at diagnosis of diabetes, and use of ACE inhibitor treatment. As reported, there was no effect of genotype on the risk. …
