Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP
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- Supplemental FIG. 1. AMPK activation induces AMPK phosphorylation and represses hepatic gluconeogenic gene expression via SHP.
- Supplemental FIG. 2. Metformin inhibits the promoter activities and gene expression of hepatic gluconeogenic genes.
- Supplemental FIG. 3. Downregulations of PEPCK and G6Pase gene expression by metformin are mediated via SHP.
- Supplemental FIG. 4. Metformin increases the phosphorylation of ACC and AMPK in liver of B6-Lepob/ob mice in a dose-dependent manner.
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Diabetes February 2008 vol. 57 no. 2 306-314
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