Comment on: Lachin et al. (2007) The Hemoglobin Glycation Index Is Not an Independent Predictor of the Risk of Microvascular Complications in the Diabetes Control and Complications Trial: Diabetes 56:1913–1921, 2007
- Stuart Chalew1,
- James Hempe2 and
- Robert McCarter3
- 1Department of Endocrinology, Children's Hospital, New Orleans, Louisiana
- 2Research Institute for Children, Children's Hospital, New Orleans, Louisiana
- 3Bioinformatics and Statistics Unit, Children's National Medical Center, Washington, D.C
- Address correspondence to Stuart Chalew, Children's Hospital, Endocrinology, 200 Henry Clay Ave., New Orleans, Louisiana 70118. E-mail: schale{at}lsuhsc.edu
Recently, Lachin et al. (1) published a reassessment of the role of the hemoglobin glycation index (HGI) for prediction of microvascular complications in the Diabetes Control and Complications Trial (DCCT). They conclude that HGI is not a useful predictor because it is not statistically independent of A1C. Their analysis was based on work from a prior publication of ours, in which we came to the conclusion that between-patient biological variation in A1C, as quantified by HGI, along with mean blood glucose (MBG) were both important predictors of complications (2). We believe that the difference in conclusions is due to a difference in the …
