Table of Contents

Online Letters to the Editor

Select this article
- David C. Thomas,
- Richard J. Mellanby,
- and Anne Cooke
Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4⁺ Regulatory T-cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007
Diabetes March 2008 57:e6; doi:10.2337/db07-1572
Select this article
- Michael Tritt,
- Evridiki Sgouroudis,
- Eva d’Hennezel,
- Alexandre Albanese,
- and Ciriaco A. Piccirillo
Response to Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007
Diabetes March 2008 57:e7-e8; doi:10.2337/db07-1710

Commentaries

Select this article
- Georgia Fousteri and
- Matthias von Herrath
First-Trimester Human Fetal Pancreas Transplantation for Type 1 Diabetes Treatment: An Alternative Approach for Achieving Long-Term Graft Survival?
Diabetes March 2008 57:525-526; doi:10.2337/db07-1409
Select this article
- Leslie J. Raffel,
- Janelle A. Noble,
- and Jerome I. Rotter
HLA on Chromosome 6: The Story Gets Longer and Longer
Diabetes March 2008 57:527-528; doi:10.2337/db07-1756
Select this article
- Frans C. Schuit and
- Daniel J. Drucker
β-Cell Replication by Loosening the Brakes of Glucagon-Like Peptide-1 Receptor Signaling
Diabetes March 2008 57:529-531; doi:10.2337/db07-1578
Select this article
- Leon A. Bach
Rho Kinase Inhibition: A New Approach for Treating Diabetic Nephropathy?
Diabetes March 2008 57:532-533; doi:10.2337/db07-1768
Select this article
- Christopher Morrison
Interaction Between Exercise and Leptin in the Treatment of Obesity
Diabetes March 2008 57:534-535; doi:10.2337/db08-0007

New Methodologies and Databases

Select this article
- Thanh T. Nguyen,
- Jie Jin Wang,
- F.M. Amirul Islam,
- Paul Mitchell,
- Robyn J. Tapp,
- Paul Z. Zimmet,
- Richard Simpson,
- Jonathan Shaw,
- and Tien Y. Wong
Retinal Arteriolar Narrowing Predicts Incidence of Diabetes: The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study
Diabetes March 2008 57:536-539; published ahead of print December 17, 2007, doi:10.2337/db07-1376

Metabolism

Select this article
- Hong Wang,
- Aileen X. Wang,
- Zhenqi Liu,
- and Eugene J. Barrett
Insulin Signaling Stimulates Insulin Transport by Bovine Aortic Endothelial Cells
Diabetes March 2008 57:540-547; published ahead of print October 31, 2007, doi:10.2337/db07-0967
Select this article
- James A. Levine,
- Shelly K. McCrady,
- Lorraine M. Lanningham-Foster,
- Paul H. Kane,
- Randal C. Foster,
- and Chinmay U. Manohar
The Role of Free-Living Daily Walking in Human Weight Gain and Obesity
Diabetes March 2008 57:548-554; published ahead of print November 14, 2007, doi:10.2337/db07-0815
Select this article
- Vanessa Tobin,
- Maude Le Gall,
- Xavier Fioramonti,
- Emilie Stolarczyk,
- Alba G. Blazquez,
- Christophe Klein,
- Magali Prigent,
- Patricia Serradas,
- Marie-Hélène Cuif,
- Christophe Magnan,
- Armelle Leturque,
- and Edith Brot-Laroche
Insulin Internalizes GLUT2 in the Enterocytes of Healthy but Not Insulin-Resistant Mice
Diabetes March 2008 57:555-562; published ahead of print December 5, 2007, doi:10.2337/db07-0928
Select this article
- Jun Nakae,
- Yongheng Cao,
- Miyo Oki,
- Yasuko Orba,
- Hirofumi Sawa,
- Hiroshi Kiyonari,
- Kristy Iskandar,
- Koji Suga,
- Marc Lombes,
- and Yoshitake Hayashi
Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure
Diabetes March 2008 57:563-576; published ahead of print December 27, 2007, doi:10.2337/db07-0698

Signal Transduction

Select this article
- Maria Teresa Gentile,
- Carmine Vecchione,
- Gennaro Marino,
- Alessandra Aretini,
- Alba Di Pardo,
- Giovanna Antenucci,
- Angelo Maffei,
- Giuseppe Cifelli,
- Luca Iorio,
- Alessandro Landolfi,
- Giacomo Frati,
- and Giuseppe Lembo
Resistin Impairs Insulin-Evoked Vasodilation
Diabetes March 2008 57:577-583; published ahead of print December 7, 2007, doi:10.2337/db07-0557
Select this article
- Sonia Klinger,
- Carine Poussin,
- Marie-Bernard Debril,
- Wanda Dolci,
- Philippe A. Halban,
- and Bernard Thorens
Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14
Diabetes March 2008 57:584-593; published ahead of print November 19, 2007, doi:10.2337/db07-1414

Obesity Studies

Select this article
- Eduardo R. Ropelle,
- José R. Pauli,
- Maria Fernanda A. Fernandes,
- Silvana A. Rocco,
- Rodrigo M. Marin,
- Joseane Morari,
- Kellen K. Souza,
- Marília M. Dias,
- Maria C. Gomes-Marcondes,
- José A.R. Gontijo,
- Kleber G. Franchini,
- Lício A. Velloso,
- Mario J.A. Saad,
- and José B.C. Carvalheira
A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss
Diabetes March 2008 57:594-605; published ahead of print December 5, 2007, doi:10.2337/db07-0573
Select this article
- Jacob E. Friedman,
- John P. Kirwan,
- Ming Jing,
- Larraine Presley,
- and Patrick M. Catalano
Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum
Diabetes March 2008 57:606-613; published ahead of print December 14, 2007, doi:10.2337/db07-1356
Select this article
- Alexandra Shapiro,
- Michael Matheny,
- Yi Zhang,
- Nihal Tümer,
- Kit-Yan Cheng,
- Enda Rogrigues,
- Sergei Zolotukhin,
- and Philip J. Scarpace
Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats
Diabetes March 2008 57:614-622; published ahead of print December 17, 2007, doi:10.2337/db07-0863
Select this article
- Thomas Reinehr,
- Anke Hinney,
- Thuy Trang Nguyen,
- and Johannes Hebebrand
Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents
Diabetes March 2008 57:623-626; published ahead of print November 14, 2007, doi:10.2337/db07-0408

Immunology and Transplantation

Select this article
- Kerstin Brands,
- Emily Colvin,
- Lindy J. Williams,
- Rennian Wang,
- Richard B. Lock,
- and Bernard E. Tuch
Reduced Immunogenicity of First-Trimester Human Fetal Pancreas
Diabetes March 2008 57:627-634; published ahead of print December 7, 2007, doi:10.2337/db07-0720a

Islet Studies

Select this article
- Dan Li,
- Xin Yin,
- Erik J. Zmuda,
- Christopher C. Wolford,
- Xiaocheng Dong,
- Morris F. White,
- and Tsonwin Hai
The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic β-Cell Apoptosis
Diabetes March 2008 57:635-644; published ahead of print December 5, 2007, doi:10.2337/db07-0717
Select this article
- Luan Shu,
- Nadine S. Sauter,
- Fabienne T. Schulthess,
- Aleksey V. Matveyenko,
- José Oberholzer,
- and Kathrin Maedler
Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets
Diabetes March 2008 57:645-653; published ahead of print December 10, 2007, doi:10.2337/db07-0847
Select this article
- Peter White,
- Catherine Lee May,
- Rodrigo N. Lamounier,
- John E. Brestelli,
- and Klaus H. Kaestner
Defining Pancreatic Endocrine Precursors and Their Descendants
Diabetes March 2008 57:654-668; published ahead of print December 10, 2007, doi:10.2337/db07-1362

Pathophysiology

Select this article
- Sandrine Boullu-Ciocca,
- Vincent Achard,
- Virginie Tassistro,
- Anne Dutour,
- and Michel Grino
Postnatal Programming of Glucocorticoid Metabolism in Rats Modulates High-Fat Diet–Induced Regulation of Visceral Adipose Tissue Glucocorticoid Exposure and Sensitivity and Adiponectin and Proinflammatory Adipokines Gene Expression in Adulthood
Diabetes March 2008 57:669-677; published ahead of print December 5, 2007, doi:10.2337/db07-1316
Select this article
- Kirsten Vollmer,
- Jens J. Holst,
- Birgit Baller,
- Mark Ellrichmann,
- Michael A. Nauck,
- Wolfgang E. Schmidt,
- and Juris J. Meier
Predictors of Incretin Concentrations in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance
Diabetes March 2008 57:678-687; published ahead of print December 5, 2007, doi:10.2337/db07-1124
Select this article
- David Z.I. Cherney,
- Judith A. Miller,
- James W. Scholey,
- Timothy J. Bradley,
- Cameron Slorach,
- Jaqueline R. Curtis,
- Maria G. Dekker,
- Rania Nasrallah,
- Richard L. Hébert,
- and Etienne B. Sochett
The Effect of Cyclooxygenase-2 Inhibition on Renal Hemodynamic Function in Humans With Type 1 Diabetes
Diabetes March 2008 57:688-695; published ahead of print December 14, 2007, doi:10.2337/db07-1230
Select this article
- John W. Calvert,
- Susheel Gundewar,
- Saurabh Jha,
- James J.M. Greer,
- William H. Bestermann,
- Rong Tian,
- and David J. Lefer
Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling
Diabetes March 2008 57:696-705; published ahead of print December 14, 2007, doi:10.2337/db07-1098
Select this article
- Wineke Bakker,
- Pieter Sipkema,
- Coen D.A. Stehouwer,
- Erik H. Serne,
- Yvo M. Smulders,
- Victor W.M. van Hinsbergh,
- and Etto C. Eringa
Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries
Diabetes March 2008 57:706-713; published ahead of print December 17, 2007, doi:10.2337/db07-0792

Complications

Select this article
- Vasantha Kolavennu,
- Lixia Zeng,
- Hui Peng,
- Yin Wang,
- and Farhad R. Danesh
Targeting of RhoA/ROCK Signaling Ameliorates Progression of Diabetic Nephropathy Independent of Glucose Control
Diabetes March 2008 57:714-723; published ahead of print December 14, 2007, doi:10.2337/db07-1241
Select this article
- David A. Ingram,
- Izlin Z. Lien,
- Laura E. Mead,
- Myka Estes,
- Daniel N. Prater,
- Ethel Derr-Yellin,
- Linda A. DiMeglio,
- and Laura S. Haneline
In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function
Diabetes March 2008 57:724-731; published ahead of print December 17, 2007, doi:10.2337/db07-1507
Select this article
- Nicola N. Zammitt,
- Roderick E. Warren,
- Ian J. Deary,
- and Brian M. Frier
Delayed Recovery of Cognitive Function Following Hypoglycemia in Adults With Type 1 Diabetes: Effect of Impaired Awareness of Hypoglycemia
Diabetes March 2008 57:732-736; published ahead of print November 26, 2007, doi:10.2337/db07-0695

Pharmacology and Therapeutics

Select this article
- Kyu Lee Han,
- Joo Sun Choi,
- Jae Young Lee,
- Jihyun Song,
- Myung Kuk Joe,
- Myeong Ho Jung,
- and Jae-Kwan Hwang
Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes
Diabetes March 2008 57:737-745; published ahead of print December 7, 2007, doi:10.2337/db07-0972
Select this article
- Paolo Rossetti,
- Francesca Porcellati,
- Natalia Busciantella Ricci,
- Paola Candeloro,
- Patrizia Cioli,
- Geremia B. Bolli,
- and Carmine G. Fanelli
Different Brain Responses to Hypoglycemia Induced by Equipotent Doses of the Long-Acting Insulin Analog Detemir and Human Regular Insulin in Humans
Diabetes March 2008 57:746-756; published ahead of print December 14, 2007, doi:10.2337/db07-1433
Select this article
- Vijay Koya,
- Shun Lu,
- Yu-Ping Sun,
- Daniel L. Purich,
- Mark A. Atkinson,
- Shi-Wu Li,
- and Li-Jun Yang
Reversal of Streptozotocin-Induced Diabetes in Mice by Cellular Transduction With Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1: A Novel Protein Transduction Domain–Based Therapy
Diabetes March 2008 57:757-769; published ahead of print December 17, 2007, doi:10.2337/db07-1441

Genetics

Select this article
- Theresa A. Aly,
- Erin E. Baschal,
- Mohamed M. Jahromi,
- Maria S. Fernando,
- Sunanda R. Babu,
- Tasha E. Fingerlin,
- Adam Kretowski,
- Henry A. Erlich,
- Pamela R. Fain,
- Marian J. Rewers,
- and George S. Eisenbarth
Analysis of Single Nucleotide Polymorphisms Identifies Major Type 1A Diabetes Locus Telomeric of the Major Histocompatibility Complex
Diabetes March 2008 57:770-776; published ahead of print December 7, 2007, doi:10.2337/db07-0900
Select this article
- Yang Liu,
- Nifang Niu,
- Xilin Zhu,
- Te Du,
- Xin Wang,
- Dongmei Chen,
- Xiaopan Wu,
- Harvest F. Gu,
- and Ying Liu
Genetic Variation and Association Analyses of the Nuclear Respiratory Factor 1 (nRF1) Gene in Chinese Patients With Type 2 Diabetes
Diabetes March 2008 57:777-782; published ahead of print December 10, 2007, doi:10.2337/db07-0008
Select this article
- Marina Ciullo,
- Teresa Nutile,
- Cyril Dalmasso,
- Rossella Sorice,
- Céline Bellenguez,
- Vincenza Colonna,
- Maria Graziella Persico,
- and Catherine Bourgain
Identification and Replication of a Novel Obesity Locus on Chromosome 1q24 in Isolated Populations of Cilento
Diabetes March 2008 57:783-790; published ahead of print December 27, 2007, doi:10.2337/db07-0970
Select this article
- Shintaro Omori,
- Yasushi Tanaka,
- Atsushi Takahashi,
- Hiroshi Hirose,
- Atsunori Kashiwagi,
- Kohei Kaku,
- Ryuzo Kawamori,
- Yusuke Nakamura,
- and Shiro Maeda
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 With Susceptibility to Type 2 Diabetes in a Japanese Population
Diabetes March 2008 57:791-795; published ahead of print December 27, 2007, doi:10.2337/db07-0979

Online Letters to the Editor

Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4+ Regulatory T-cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007

Response to Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4+ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007

Commentaries

First-Trimester Human Fetal Pancreas Transplantation for Type 1 Diabetes Treatment: An Alternative Approach for Achieving Long-Term Graft Survival?

HLA on Chromosome 6: The Story Gets Longer and Longer

β-Cell Replication by Loosening the Brakes of Glucagon-Like Peptide-1 Receptor Signaling

Rho Kinase Inhibition: A New Approach for Treating Diabetic Nephropathy?

Interaction Between Exercise and Leptin in the Treatment of Obesity

New Methodologies and Databases

Retinal Arteriolar Narrowing Predicts Incidence of Diabetes: The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study

Metabolism

Insulin Signaling Stimulates Insulin Transport by Bovine Aortic Endothelial Cells

The Role of Free-Living Daily Walking in Human Weight Gain and Obesity

Insulin Internalizes GLUT2 in the Enterocytes of Healthy but Not Insulin-Resistant Mice

Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure

Signal Transduction

Resistin Impairs Insulin-Evoked Vasodilation

Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14

Obesity Studies

A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss

Increased Skeletal Muscle Tumor Necrosis Factor-α and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum

Synergy Between Leptin Therapy and a Seemingly Negligible Amount of Voluntary Wheel Running Prevents Progression of Dietary Obesity in Leptin-Resistant Rats

Evidence of an Influence of a Polymorphism Near the INSIG2 on Weight Loss During a Lifestyle Intervention in Obese Children and Adolescents

Immunology and Transplantation

Reduced Immunogenicity of First-Trimester Human Fetal Pancreas

Islet Studies

The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic β-Cell Apoptosis

Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets

Defining Pancreatic Endocrine Precursors and Their Descendants

Pathophysiology

Postnatal Programming of Glucocorticoid Metabolism in Rats Modulates High-Fat Diet–Induced Regulation of Visceral Adipose Tissue Glucocorticoid Exposure and Sensitivity and Adiponectin and Proinflammatory Adipokines Gene Expression in Adulthood

Predictors of Incretin Concentrations in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance

The Effect of Cyclooxygenase-2 Inhibition on Renal Hemodynamic Function in Humans With Type 1 Diabetes

Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling

Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries

Complications

Targeting of RhoA/ROCK Signaling Ameliorates Progression of Diabetic Nephropathy Independent of Glucose Control

In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function

Delayed Recovery of Cognitive Function Following Hypoglycemia in Adults With Type 1 Diabetes: Effect of Impaired Awareness of Hypoglycemia

Pharmacology and Therapeutics

Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes

Different Brain Responses to Hypoglycemia Induced by Equipotent Doses of the Long-Acting Insulin Analog Detemir and Human Regular Insulin in Humans

Reversal of Streptozotocin-Induced Diabetes in Mice by Cellular Transduction With Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1: A Novel Protein Transduction Domain–Based Therapy

Genetics

Analysis of Single Nucleotide Polymorphisms Identifies Major Type 1A Diabetes Locus Telomeric of the Major Histocompatibility Complex

Genetic Variation and Association Analyses of the Nuclear Respiratory Factor 1 (nRF1) Gene in Chinese Patients With Type 2 Diabetes

Identification and Replication of a Novel Obesity Locus on Chromosome 1q24 in Isolated Populations of Cilento

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 With Susceptibility to Type 2 Diabetes in a Japanese Population

This Issue

Current Issue

Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4⁺ Regulatory T-cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007

Response to Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007