Comment on: Tritt et al. (2007) Functional Waning of Naturally Occurring CD4+ Regulatory T-cells Contributes to the Onset of Autoimmune Diabetes: Diabetes 57:113–123, 2007
- 1Cambridge Institute For Medical Research, Addenbrooke’s Hospital, Cambridge, U.K
- 2Division of Veterinary Clinical Studies, Royal School of Veterinary Studies, University of Edinburgh, Midlothian, U.K
- 3Department of Pathology, University of Cambridge, Cambridge, U.K
- Address correspondence and reprint requests to Dr. David C. Thomas, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0XY, U.K. E-mail: tdct2{at}cam.ac.uk
We read with interest the recent study by Tritt et al. (1), which examined the Foxp3+ regulatory T-cells (Tregs) of NOD and BDC2.5NOD mice. The authors found that Tregs from 6- to 8-week-old BDC2.5NOD mice, but not those from 3- to 4-week-old mice, were unable to suppress diabetes in an in vivo transfer model. We feel, however, that a wealth of evidence has underlined the crucial importance of these cells in BDC2.5NOD …
