Table of Contents

April 2008; 57 (4)

Commentaries

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- John A. Corbett
Thioredoxin-Interacting Protein Is Killing My β-cells!
Diabetes April 2008 57:797-798; doi:10.2337/db08-0055
Select this article
- Benjamin Glaser
Insulin Mutations in Diabetes: The Clinical Spectrum
Diabetes April 2008 57:799-800; doi:10.2337/db08-0116

Metabolism

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- Bee K. Tan,
- Raghu Adya,
- S. Farhatullah,
- Kris C. Lewandowski,
- Paul O’Hare,
- Hendrik Lehnert,
- and Harpal S. Randeva
Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome: Ex Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose
Diabetes April 2008 57:801-808; published ahead of print January 3, 2008, doi:10.2337/db07-0990
Select this article
- Chao-Qiang Lai,
- Katherine L. Tucker,
- Laurence D. Parnell,
- Xian Adiconis,
- Bibiana García-Bailo,
- John Griffith,
- Mohsen Meydani,
- and José M. Ordovás
PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases : The Boston Puerto Rican Health Study
Diabetes April 2008 57:809-816; published ahead of print December 27, 2007, doi:10.2337/db07-1238
Select this article
- Yin Li,
- Changtao Jiang,
- Guoheng Xu,
- Nanping Wang,
- Yi Zhu,
- Chaoshu Tang,
- and Xian Wang
Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro
Diabetes April 2008 57:817-827; published ahead of print January 11, 2008, doi:10.2337/db07-0617
Select this article
- Jenny D. Chiu,
- Joyce M. Richey,
- L. Nicole Harrison,
- Edward Zuniga,
- Cathryn M. Kolka,
- Erlinda Kirkman,
- Martin Ellmerer,
- and Richard N. Bergman
Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal
Diabetes April 2008 57:828-835; published ahead of print January 25, 2008, doi:10.2337/db07-1444
Select this article
- Madhu Chari,
- Carol K.L. Lam,
- Penny Y.T. Wang,
- and Tony K.T. Lam
Activation of Central Lactate Metabolism Lowers Glucose Production in Uncontrolled Diabetes and Diet-Induced Insulin Resistance
Diabetes April 2008 57:836-840; published ahead of print January 9, 2008, doi:10.2337/db07-1464
Select this article
- Jose E. Galgani,
- Leonie K. Heilbronn,
- Koichiro Azuma,
- David E. Kelley,
- Jeanine B. Albu,
- Xavier Pi-Sunyer,
- Steven R. Smith,
- Eric Ravussin,
- and and the Look AHEAD Adipose Research Group
Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate
Diabetes April 2008 57:841-845; published ahead of print February 19, 2008, doi:10.2337/db08-0043

Signal Transduction

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- Sara C. Martinez,
- Katsuya Tanabe,
- Corentin Cras-Méneur,
- Nada A. Abumrad,
- Ernesto Bernal-Mizrachi,
- and M. Alan Permutt
Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis
Diabetes April 2008 57:846-859; published ahead of print January 3, 2008, doi:10.2337/db07-0595
Select this article
- Sean L. McGee,
- Bryce J.W. van Denderen,
- Kirsten F. Howlett,
- Janelle Mollica,
- Jonathan D. Schertzer,
- Bruce E. Kemp,
- and Mark Hargreaves
AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5
Diabetes April 2008 57:860-867; published ahead of print January 9, 2008, doi:10.2337/db07-0843
Select this article
- Byung-Ju Kim,
- Kwang-Hyun Park,
- Chang-Yeol Yim,
- Shin Takasawa,
- Hiroshi Okamoto,
- Mie-Jae Im,
- and Uh-Hyun Kim
Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca²⁺ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets
Diabetes April 2008 57:868-878; published ahead of print January 9, 2008, doi:10.2337/db07-0443
Select this article
- Narkunarajaa Shanmugam,
- James L. Figarola,
- Yan Li,
- Piotr M. Swiderski,
- Samual Rahbar,
- and Rama Natarajan
Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes
Diabetes April 2008 57:879-888; published ahead of print November 14, 2007, doi:10.2337/db07-1204
Select this article
- Tayyeba K. Ali,
- Suraporn Matragoon,
- Bindu A. Pillai,
- Gregory I. Liou,
- and Azza B. El-Remessy
Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes
Diabetes April 2008 57:889-898; published ahead of print February 19, 2008, doi:10.2337/db07-1669

Obesity Studies

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- Alberto O. Chavez,
- Juan C. Lopez-Alvarenga,
- M. Elizabeth Tejero,
- Curtis Triplitt,
- Raul A. Bastarrachea,
- Apiradee Sriwijitkamol,
- Puntip Tantiwong,
- V. Saroja Voruganti,
- Nicolas Musi,
- Anthony G. Comuzzie,
- Ralph A. DeFronzo,
- and Franco Folli
Physiological and Molecular Determinants of Insulin Action in the Baboon
Diabetes April 2008 57:899-908; published ahead of print January 3, 2008, doi:10.2337/db07-0790

Immunology and Transplantation

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- Gillian M. Brodie,
- Maja Wallberg,
- Pere Santamaria,
- F. Susan Wong,
- and E. Allison Green
B-Cells Promote Intra-Islet CD8⁺ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes
Diabetes April 2008 57:909-917; published ahead of print January 9, 2008, doi:10.2337/db07-1256
Select this article
- Hubert Tsui,
- Yin Chan,
- Lan Tang,
- Shawn Winer,
- Roy K. Cheung,
- Geoffrey Paltser,
- Thirumahal Selvanantham,
- Alisha R. Elford,
- James R. Ellis,
- Dorothy J. Becker,
- Pamela S. Ohashi,
- and Hans-Michael Dosch
Targeting of Pancreatic Glia in Type 1 Diabetes
Diabetes April 2008 57:918-928; published ahead of print January 15, 2008, doi:10.2337/db07-0226
Select this article
- Christian Pfleger,
- Henrik B. Mortensen,
- Lars Hansen,
- Christian Herder,
- Bart O. Roep,
- Hillary Hoey,
- Henk-Jan Aanstoot,
- Mirjana Kocova,
- Nanette C. Schloot,
- and on behalf of the Hvidøre Study Group on Childhood Diabetes
Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes
Diabetes April 2008 57:929-937; published ahead of print February 25, 2008, doi:10.2337/db07-1697

Islet Studies

Select this article
- Junqin Chen,
- Geetu Saxena,
- Imran N. Mungrue,
- Aldons J. Lusis,
- and Anath Shalev
Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and β-Cell Apoptosis
Diabetes April 2008 57:938-944; published ahead of print January 2, 2008, doi:10.2337/db07-0715
Select this article
- Merav Fraenkel,
- Mali Ketzinel-Gilad,
- Yafa Ariav,
- Orit Pappo,
- Melis Karaca,
- Julien Castel,
- Marie-France Berthault,
- Christophe Magnan,
- Erol Cerasi,
- Nurit Kaiser,
- and Gil Leibowitz
mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
Diabetes April 2008 57:945-957; published ahead of print January 3, 2008, doi:10.2337/db07-0922
Select this article
- David A. Cano,
- Ingrid C. Rulifson,
- Patrick W. Heiser,
- Lamorna B. Swigart,
- Stella Pelengaris,
- Mike German,
- Gerard I. Evan,
- Jeffrey A. Bluestone,
- and Matthias Hebrok
Regulated β-Cell Regeneration in the Adult Mouse Pancreas
Diabetes April 2008 57:958-966; published ahead of print December 14, 2007, doi:10.2337/db07-0913
Select this article
- Riccarda Granata,
- Fabio Settanni,
- Davide Gallo,
- Letizia Trovato,
- Luigi Biancone,
- Vincenzo Cantaluppi,
- Rita Nano,
- Marta Annunziata,
- Pietro Campiglia,
- Elisa Arnoletti,
- Corrado Ghè,
- Marco Volante,
- Mauro Papotti,
- Giampiero Muccioli,
- and Ezio Ghigo
Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function
Diabetes April 2008 57:967-979; published ahead of print December 27, 2007, doi:10.2337/db07-1104

Pathophysiology

Select this article
- Kieren J. Mather,
- Tohru Funahashi,
- Yuji Matsuzawa,
- Sharon Edelstein,
- George A. Bray,
- Steven E. Kahn,
- Jill Crandall,
- Santica Marcovina,
- Barry Goldstein,
- Ronald Goldberg,
- and for the Diabetes Prevention Program
Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program
Diabetes April 2008 57:980-986; published ahead of print January 11, 2008, doi:10.2337/db07-1419
Select this article
- Frederico G.S. Toledo,
- Elizabeth V. Menshikova,
- Koichiro Azuma,
- Zofia Radiková,
- Carol A. Kelley,
- Vladimir B. Ritov,
- and David E. Kelley
Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content
Diabetes April 2008 57:987-994; published ahead of print February 5, 2008, doi:10.2337/db07-1429

Complications

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- John M. Lachin,
- Saul Genuth,
- David M. Nathan,
- Bernard Zinman,
- Brandy N. Rutledge,
- and for the DCCT/EDIC Research Group
Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited
Diabetes April 2008 57:995-1001; published ahead of print January 25, 2008, doi:10.2337/db07-1618
Select this article
- Cory Toth,
- Ling Ling Rong,
- Christina Yang,
- Jose Martinez,
- Fei Song,
- Noor Ramji,
- Valentine Brussee,
- Wei Liu,
- Jeff Durand,
- Minh Dang Nguyen,
- Ann Marie Schmidt,
- and Douglas W. Zochodne
Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy
Diabetes April 2008 57:1002-1017; published ahead of print November 26, 2007, doi:10.2337/db07-0339
Select this article
- Chris Tikellis,
- Katarzyna Bialkowski,
- Josepha Pete,
- Karen Sheehy,
- Qui Su,
- Colin Johnston,
- Mark E. Cooper,
- and Merlin C. Thomas
ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes
Diabetes April 2008 57:1018-1025; published ahead of print January 30, 2008, doi:10.2337/db07-1212

Original Articles

Pharmacology and Therapeutics

Select this article
- Xinyuan Zhang,
- Shisan Bao,
- Donna Lai,
- Robert W. Rapkins,
- and Mark C. Gillies
Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas
Diabetes April 2008 57:1026-1033; published ahead of print January 3, 2008, doi:10.2337/db07-0982

Current Issue

February 2012, 61 (2)

Print ISSN: 0012-1797
Online ISSN: 1939-327X

Diabetes

Commentaries

Thioredoxin-Interacting Protein Is Killing My β-cells!

Insulin Mutations in Diabetes: The Clinical Spectrum

Metabolism

Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome: Ex Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose

PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases : The Boston Puerto Rican Health Study

Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro

Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal

Activation of Central Lactate Metabolism Lowers Glucose Production in Uncontrolled Diabetes and Diet-Induced Insulin Resistance

Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

Signal Transduction

Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets

Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes

Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes

Obesity Studies

Physiological and Molecular Determinants of Insulin Action in the Baboon

Immunology and Transplantation

B-Cells Promote Intra-Islet CD8+ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes

Targeting of Pancreatic Glia in Type 1 Diabetes

Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes

Islet Studies

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and β-Cell Apoptosis

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

Regulated β-Cell Regeneration in the Adult Mouse Pancreas

Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function

Pathophysiology

Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

Complications

Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited

Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy

ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes

Original Articles

Pharmacology and Therapeutics

Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas

Genetics

Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood

A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients

Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans

Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy

The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men

HNF4α and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy

Variations of the Perforin Gene in Patients With Type 1 Diabetes

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study

Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes in the Women's Health Initiative Observational Study

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: A Report From the French ND (Neonatal Diabetes) Study Group

Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort

The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European Populations: Evidence From an Updated Meta-Analysis in 42,042 Subjects

Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes

Association of Variants in the Sterol Regulatory Element-Binding Factor 1 (SREBF1) Gene With Type 2 Diabetes, Glycemia, and Insulin Resistance: A Study of 15,734 Danish Subjects

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study

This Issue

Current Issue

Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca²⁺ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets

B-Cells Promote Intra-Islet CD8⁺ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes