Table of Contents

May 2008; 57 (5)

Online Letters to the Editor

    • Sten A. Ivarsson and
    • Åke Lernmark

    Comment on: Edghill et al. (2008) Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood: Diabetes 57:1034–1042, 2008

    Diabetes May 2008 57:e9; doi:10.2337/db08-0091
    • Petra-Susanne Klein

    Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007

    Diabetes May 2008 57:e10; doi:10.2337/db08-0173
    • Joseph DiChiara,
    • Kevin P. Bliden,
    • Udaya S. Tantry,
    • Miruais S. Hamed,
    • Mark J. Antonino,
    • Thomas A. Suarez,
    • Oscar Bailon,
    • Anand Singla,
    • and Paul A. Gurbel

    Response to Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007

    Diabetes May 2008 57:e11; doi:10.2337/db08-0250

Commentaries

    • Anthony J.G. Hanley and
    • Lynne E. Wagenknecht

    Abdominal Adiposity and Diabetes Risk: The Importance of Precise Measures and Longitudinal Studies

    Diabetes May 2008 57:1153-1155; doi:10.2337/db08-0286
    • Bart O. Roep

    Islet Autoreactive CD8 T-cells in Type 1 Diabetes: Licensed to Kill?

    Diabetes May 2008 57:1156; doi:10.2337/db08-0264
    • Alan D. Cherrington

    Central Versus Peripheral Glucose Sensing and the Response to Hypoglycemia

    Diabetes May 2008 57:1158-1159; doi:10.2337/db08-0315
    • Andrea K. Steck and
    • George S. Eisenbarth

    Genetic Similarities Between Latent Autoimmune Diabetes and Type 1 and Type 2 Diabetes

    Diabetes May 2008 57:1160-1162; doi:10.2337/db07-1786

Editorial

    • William T. Cefalu and
    • Karol Watson

    Intensive Glycemic Control and Cardiovascular Disease Observations From the ACCORD Study: Now What Can a Clinician Possibly Think?

    Diabetes May 2008 57:1163-1165; doi:10.2337/db08-0220

Metabolism

    • K. Sreekumaran Nair,
    • Maureen L. Bigelow,
    • Yan W. Asmann,
    • Lisa S. Chow,
    • Jill M. Coenen-Schimke,
    • Katherine A. Klaus,
    • Zeng-Kui Guo,
    • Raghavakaimal Sreekumar,
    • and Brian A. Irving

    Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

    Diabetes May 2008 57:1166-1175; published ahead of print February 19, 2008, doi:10.2337/db07-1556
    • Christopher R. Cederroth,
    • Manlio Vinciguerra,
    • Asllan Gjinovci,
    • Françoise Kühne,
    • Marcella Klein,
    • Manon Cederroth,
    • Dorothée Caille,
    • Mariane Suter,
    • Dietbert Neumann,
    • Richard W. James,
    • Daniel R. Doerge,
    • Theo Wallimann,
    • Paolo Meda,
    • Michelangelo Foti,
    • Françoise Rohner-Jeanrenaud,
    • Jean-Dominique Vassalli,
    • and Serge Nef

    Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism

    Diabetes May 2008 57:1176-1185; published ahead of print April 16, 2008, doi:10.2337/db07-0630
    • Christina Koutsari,
    • Daniel A. Dumesic,
    • Bruce W. Patterson,
    • Susanne B. Votruba,
    • and Michael D. Jensen

    Plasma Free Fatty Acid Storage in Subcutaneous and Visceral Adipose Tissue in Postabsorptive Women

    Diabetes May 2008 57:1186-1194; published ahead of print February 19, 2008, doi:10.2337/db07-0664

Signal Transduction

    • Karim Bouzakri,
    • Pascale Ribaux,
    • Alejandra Tomas,
    • Geraldine Parnaud,
    • Katharina Rickenbach,
    • and Philippe A. Halban

    Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells

    Diabetes May 2008 57:1195-1204; published ahead of print February 14, 2008, doi:10.2337/db07-1469
    • Mourad Ferdaoussi,
    • Saida Abdelli,
    • Jiang-Yan Yang,
    • Marion Cornu,
    • Guy Niederhauser,
    • Dimitri Favre,
    • Christian Widmann,
    • Romano Regazzi,
    • Bernard Thorens,
    • Gérard Waeber,
    • and Amar Abderrahmani

    Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

    Diabetes May 2008 57:1205-1215; published ahead of print February 5, 2008, doi:10.2337/db07-1214
    • Damien Demozay,
    • Jean-Christophe Mas,
    • Stephane Rocchi,
    • and Emmanuel Van Obberghen

    FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes

    Diabetes May 2008 57:1216-1226; published ahead of print January 3, 2008, doi:10.2337/db07-0389
    • Akira Moh,
    • Wenjun Zhang,
    • Sidney Yu,
    • Jun Wang,
    • Xuming Xu,
    • Jiliang Li,
    • and Xin-Yuan Fu

    STAT3 Sensitizes Insulin Signaling by Negatively Regulating Glycogen Synthase Kinase-3β

    Diabetes May 2008 57:1227-1235; published ahead of print February 11, 2008, doi:10.2337/db06-1582
    • Zeynep Dogusan,
    • Mónica García,
    • Daisy Flamez,
    • Lena Alexopoulou,
    • Michel Goldman,
    • Conny Gysemans,
    • Chantal Mathieu,
    • Claude Libert,
    • Decio L. Eizirik,
    • and Joanne Rasschaert

    Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways

    Diabetes May 2008 57:1236-1245; published ahead of print January 25, 2008, doi:10.2337/db07-0844

Obesity Studies

    • Xinmei Zhang,
    • Dennis C.Y. Yeung,
    • Michal Karpisek,
    • David Stejskal,
    • Zhi-Guang Zhou,
    • Feng Liu,
    • Rachel L.C. Wong,
    • Wing-Sun Chow,
    • Annette W.K. Tso,
    • Karen S.L. Lam,
    • and Aimin Xu

    Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

    Diabetes May 2008 57:1246-1253; published ahead of print February 5, 2008, doi:10.2337/db07-1476
    • Elizabeth A. Kirk,
    • Zachary K. Sagawa,
    • Thomas O. McDonald,
    • Kevin D. O'Brien,
    • and Jay W. Heinecke

    Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue

    Diabetes May 2008 57:1254-1261; published ahead of print February 11, 2008, doi:10.2337/db07-1061
    • Tara M. D'Eon,
    • Kerry A. Pierce,
    • Jeffery J. Roix,
    • Andrew Tyler,
    • Hong Chen,
    • and Sandra R. Teixeira

    The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids

    Diabetes May 2008 57:1262-1268; published ahead of print February 14, 2008, doi:10.2337/db07-1186
    • Tomoshige Hayashi,
    • Edward J. Boyko,
    • Marguerite J. McNeely,
    • Donna L. Leonetti,
    • Steven E. Kahn,
    • and Wilfred Y. Fujimoto

    Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans

    Diabetes May 2008 57:1269-1275; published ahead of print February 25, 2008, doi:10.2337/db07-1378

Immunology and Transplantation

    • Claudio Tiberti,
    • Carla Giordano,
    • Mattia Locatelli,
    • Emanuele Bosi,
    • Gian Franco Bottazzo,
    • Raffaella Buzzetti,
    • Domenico Cucinotta,
    • Aldo Galluzzo,
    • Alberto Falorni,
    • and Francesco Dotta

    Identification of Tyrosine Phosphatase 2(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2

    Diabetes May 2008 57:1276-1283; published ahead of print March 10, 2008, doi:10.2337/db07-0874
    • Mark D. McKenzie,
    • Emma M. Carrington,
    • Thomas Kaufmann,
    • Andreas Strasser,
    • David C.S. Huang,
    • Thomas W.H. Kay,
    • Janette Allison,
    • and Helen E. Thomas

    Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells

    Diabetes May 2008 57:1284-1292; published ahead of print February 5, 2008, doi:10.2337/db07-1692
    • Gustavo Fenalti,
    • Christiane S. Hampe,
    • Yasir Arafat,
    • Ruby H.P. Law,
    • J. Paul Banga,
    • Ian R. Mackay,
    • James C. Whisstock,
    • Ashley M. Buckle,
    • and Merrill J. Rowley

    COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

    Diabetes May 2008 57:1293-1301; published ahead of print January 9, 2008, doi:10.2337/db07-1461
    • Martin J. Richer,
    • Nadine Straka,
    • Dianne Fang,
    • Iryna Shanina,
    • and Marc S. Horwitz

    Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor-β

    Diabetes May 2008 57:1302-1311; published ahead of print February 11, 2008, doi:10.2337/db07-1460
    • Emanuela Martinuzzi,
    • Giulia Novelli,
    • Matthieu Scotto,
    • Philippe Blancou,
    • Jean-Marie Bach,
    • Lucy Chaillous,
    • Graziella Bruno,
    • Lucienne Chatenoud,
    • Peter van Endert,
    • and Roberto Mallone

    The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

    Diabetes May 2008 57:1312-1320; published ahead of print February 27, 2008, doi:10.2337/db07-1594
    • Amanda R. Burton,
    • Erica Vincent,
    • Paula Y. Arnold,
    • Greig P. Lennon,
    • Matthew Smeltzer,
    • Chin-Shang Li,
    • Kathryn Haskins,
    • John Hutton,
    • Roland M. Tisch,
    • Eli E. Sercarz,
    • Pere Santamaria,
    • Creg J. Workman,
    • and Dario A.A. Vignali

    On the Pathogenicity of Autoantigen-Specific T-Cell Receptors

    Diabetes May 2008 57:1321-1330; published ahead of print February 25, 2008, doi:10.2337/db07-1129
    • Su-Jin Kim,
    • Cuilan Nian,
    • Doris J. Doudet,
    • and Christopher H.S. McIntosh

    Inhibition of Dipeptidyl Peptidase IV With Sitagliptin (MK0431) Prolongs Islet Graft Survival in Streptozotocin-Induced Diabetic Mice

    Diabetes May 2008 57:1331-1339; published ahead of print February 25, 2008, doi:10.2337/db07-1639

Pathophysiology

    • Elza Muscelli,
    • Andrea Mari,
    • Arturo Casolaro,
    • Stefania Camastra,
    • Giuseppe Seghieri,
    • Amalia Gastaldelli,
    • Jens J. Holst,
    • and Ele Ferrannini

    Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients

    Diabetes May 2008 57:1340-1348; published ahead of print December 27, 2007, doi:10.2337/db07-1315
    • Antonio Ceriello,
    • Katherine Esposito,
    • Ludovica Piconi,
    • Michael A. Ihnat,
    • Jessica E. Thorpe,
    • Roberto Testa,
    • Massimo Boemi,
    • and Dario Giugliano

    Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients

    Diabetes May 2008 57:1349-1354; published ahead of print February 25, 2008, doi:10.2337/db08-0063
    • Luca Valenti,
    • Raffaela Rametta,
    • Paola Dongiovanni,
    • Marco Maggioni,
    • Anna Ludovica Fracanzani,
    • Marco Zappa,
    • Enzo Lattuada,
    • Giancarlo Roviaro,
    • and Silvia Fargion

    Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

    Diabetes May 2008 57:1355-1362; published ahead of print March 3, 2008, doi:10.2337/db07-0714

Complications

    • Owen Chan,
    • Haiying Cheng,
    • Raimund Herzog,
    • Daniel Czyzyk,
    • Wanling Zhu,
    • Ajin Wang,
    • Rory J. McCrimmon,
    • Margretta R. Seashore,
    • and Robert S. Sherwin

    Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia

    Diabetes May 2008 57:1363-1370; published ahead of print March 28, 2008, doi:10.2337/db07-1559
    • Barry E. Levin,
    • Thomas C. Becker,
    • Jun-ichi Eiki,
    • Bei B. Zhang,
    • and Ambrose A. Dunn-Meynell

    Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia

    Diabetes May 2008 57:1371-1379; published ahead of print February 21, 2008, doi:10.2337/db07-1755
    • Maziyar Saberi,
    • MaryAnn Bohland,
    • and Casey M. Donovan

    The Locus for Hypoglycemic Detection Shifts With the Rate of Fall in Glycemia: The Role of Portal–Superior Mesenteric Vein Glucose Sensing

    Diabetes May 2008 57:1380-1386; published ahead of print February 21, 2008, doi:10.2337/db07-1528
    • Rose A. Gubitosi-Klug,
    • Ramaprasad Talahalli,
    • Yunpeng Du,
    • Jerry L. Nadler,
    • and Timothy S. Kern

    5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

    Diabetes May 2008 57:1387-1393; published ahead of print March 17, 2008, doi:10.2337/db07-1217

Pharmacology and Therapeutics

    • Federico Biscetti,
    • Eleonora Gaetani,
    • Andrea Flex,
    • Tamar Aprahamian,
    • Teresa Hopkins,
    • Giuseppe Straface,
    • Giovanni Pecorini,
    • Egidio Stigliano,
    • Roy C. Smith,
    • Flavia Angelini,
    • John J. Castellot, Jr.,
    • and Roberto Pola

    Selective Activation of Peroxisome Proliferator–Activated Receptor (PPAR)α and PPARγ Induces Neoangiogenesis Through a Vascular Endothelial Growth Factor–Dependent Mechanism

    Diabetes May 2008 57:1394-1404; published ahead of print February 11, 2008, doi:10.2337/db07-0765
    • Markus Clemenz,
    • Nikolaj Frost,
    • Michael Schupp,
    • Sandrine Caron,
    • Anna Foryst-Ludwig,
    • Christian Böhm,
    • Martin Hartge,
    • Ronald Gust,
    • Bart Staels,
    • Thomas Unger,
    • and Ulrich Kintscher

    Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan

    Diabetes May 2008 57:1405-1413; published ahead of print January 9, 2008, doi:10.2337/db07-0839
    • Nigel Turner,
    • Jing-Ya Li,
    • Alison Gosby,
    • Sabrina W.C. To,
    • Zhe Cheng,
    • Hiroyuki Miyoshi,
    • Makoto M. Taketo,
    • Gregory J. Cooney,
    • Edward W. Kraegen,
    • David E. James,
    • Li-Hong Hu,
    • Jia Li,
    • and Ji-Ming Ye

    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

    Diabetes May 2008 57:1414-1418; published ahead of print February 19, 2008, doi:10.2337/db07-1552

Genetics

    • Rachel M. Freathy,
    • Nicholas J. Timpson,
    • Debbie A. Lawlor,
    • Anneli Pouta,
    • Yoav Ben-Shlomo,
    • Aimo Ruokonen,
    • Shah Ebrahim,
    • Beverley Shields,
    • Eleftheria Zeggini,
    • Michael N. Weedon,
    • Cecilia M. Lindgren,
    • Hana Lango,
    • David Melzer,
    • Luigi Ferrucci,
    • Giuseppe Paolisso,
    • Matthew J. Neville,
    • Fredrik Karpe,
    • Colin N.A. Palmer,
    • Andrew D. Morris,
    • Paul Elliott,
    • Marjo-Riitta Jarvelin,
    • George Davey Smith,
    • Mark I. McCarthy,
    • Andrew T. Hattersley,
    • and Timothy M. Frayling

    Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

    Diabetes May 2008 57:1419-1426; published ahead of print March 17, 2008, doi:10.2337/db07-1466
    • Gitte Andersen,
    • Kristoffer Sølvsten Burgdorf,
    • Thomas Sparsø,
    • Knut Borch-Johnsen,
    • Torben Jørgensen,
    • Torben Hansen,
    • and Oluf Pedersen

    AHSG Tag Single Nucleotide Polymorphisms Associate With Type 2 Diabetes and Dyslipidemia: Studies of Metabolic Traits in 7,683 White Danish Subjects

    Diabetes May 2008 57:1427-1432; published ahead of print March 3, 2008, doi:10.2337/db07-0558
    • Camilla Cervin,
    • Valeriya Lyssenko,
    • Ekaterine Bakhtadze,
    • Eero Lindholm,
    • Peter Nilsson,
    • Tiinamaija Tuomi,
    • Corrado M. Cilio,
    • and Leif Groop

    Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

    Diabetes May 2008 57:1433-1437; published ahead of print February 29, 2008, doi:10.2337/db07-0299
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This Issue

May 2008; 57 (5)
  1. Online Letters to the Editor
  2. Commentaries
  3. Editorial
  4. Metabolism
  5. Signal Transduction
  6. Obesity Studies
  7. Immunology and Transplantation
  8. Pathophysiology
  9. Complications
  10. Pharmacology and Therapeutics
  11. Genetics

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