Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

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FIG. 2.
FIG. 2.

Antibiotic treatment reduced the occurrence of visceral adipose tissue inflammation, oxidative stress, and macrophage infiltration markers in high-fat diet–fed mice. Inflammation: PAI-1, IL-1, and TNF-α mRNA concentrations (A, D, and G); oxidative stress: STAMP-2 and NADPHox mRNA concentrations (B and E); macrophage infiltration markers: MCP-1 and F4/80 mRNA concentrations (C and F), visceral adipose tissue oxidative stress levels (lipid peroxides concentrations) (H) in mice fed normal diet (CT), normal diet and antibiotics (CT-Ab), high-fat diet (HF), or high-fat diet and antibiotics (HF-Ab) for 4 weeks. Data are means ± SE. Data with different superscript letters are significantly different (P < 0.05) according to the post hoc ANOVA statistical analysis.

This Article

  1. Diabetes vol. 57 no. 6 1470-1481