Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

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FIG. 4.
FIG. 4.

Metabolic endotoxemia positively correlated with inflammation, oxidative stress, and macrophage infiltration markers. Correlations between plasma endotoxin (LPS, EU/ml) and PAI-1 (A), STAMP2 (B), and F4/80 (C) mRNA concentrations; correlations between PAI-1 mRNA concentrations and IL-1 (D), STAMP2 (E), and F4/80 mRNA (F) concentrations; correlations between NADPHox mRNA concentrations and PAI-1 (G), STAMP2 (H), and F4/80 mRNA (I) concentrations in the visceral adipose depots of mice fed normal diet (CT), normal diet and antibiotic (CT-Ab), high-fat diet (HF), or high-fat diet and antibiotics (HF-Ab) for 4 weeks. P < 0.05, inset corresponds to Pearson's r correlation and corresponding P value.

This Article

  1. Diabetes vol. 57 no. 6 1470-1481