Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 6.
FIG. 6.

Antibiotic treatment improved metabolic parameters of diabetes and obesity in high-fat diet–fed mice. A: Plasma glucose (mmol/l) after an oral glucose load (1 g/kg) in mice fed normal diet (CT), normal diet and antibiotics (CT-Ab), high-fat diet (HF), or high-fat diet and antibiotics (HF-Ab) for 4 weeks. The inset represents the area under curve (AUC) of the same groups. B: Plasma insulin concentration (pmol/l) 30 min before (−30) and 15 min after (15) oral glucose administration of the same groups. C: Insulin resistance index. D: Glucose-induced insulin secretion after oral glucose administration. E: Body weight gain. F: Total energy intake. G: Subcutaneous adipose tissue weight (percent body weight). H: Visceral adipose tissue weight (percent body weight) in mice fed normal diet (CT), normal diet and antibiotics (CT-Ab), high-fat diet (HF), or high-fat diet and antibiotics (HF-Ab) for 4 weeks. Data are means ± SE. Data with different superscript letters are significantly different (P < 0.05) according to the post hoc ANOVA statistical analysis.

This Article

  1. Diabetes vol. 57 no. 6 1470-1481