Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

TABLE 1

Bacterial quantification

Lactobacillus spp. (cells/g cecal content) Bifidobacterium spp. (cells/g cecal content) Bacteroides-Prevotella spp. (cells/g cecal content)
Control 6.6 108 ± 3.4 108a 4.8 106 ± 1.1 106a 4.7 108 ± 5.8 108a
High fat 3.0 107 ± 5.7 106b 5.9 105 ± 2.2 105a 1.2 109 ± 6.4 108b
Control antibiotic 2.1 105 ± 3.8 104c 1.0 104 ± 4.9 103b 5.1 107 ± 4.4 107c
High-fat antibiotic 3.9 105 ± 5.3 104c 4.5 104 ± 2.3 104b 2.1 108 ± 1.9 108a
ob/ob control 3.8 109 ± 1.2 109a 8.5 106 ± 3.8 106a 1.5 108 ± 7.6 107
ob/ob antibiotic 1.8 106 ± 5.7 105b 1.4 106 ± 4.1 105b Nondetectable
  • Data are means ± SE. Data with different letters are significantly different (P < 0.05) according to the post hoc ANOVA or Student's t test statistical analysis.

This Article

  1. Diabetes vol. 57 no. 6 1470-1481