Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

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FIG. 2.FIG. 2.
FIG. 2.

Dapagliflozin reduces plasma glucose excursions in normal rats. A: Plasma glucose excursion curves over 1 h post–glucose challenge. ○, Vehicle; ♦, 0.01 mg/kg; ▴, 0.1 mg/kg; ж, 1 mg/kg; ▪, 10 mg/kg. B: The delta area under the curve (AUC) from baseline plasma glucose values for vehicle- and dapagliflozin-treated rats. *P < 0.05, †P < 0.005, each vs. vehicle.

This Article

  1. Diabetes vol. 57 no. 6 1723-1729