Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

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FIG. 4.
FIG. 4.

Dapagliflozin lowers plasma glucose levels in ZDF rats after single oral doses. Rats were in the fed state at the initiation of the experiment. Access to food was restricted over the first 6 h post-dose, but access to food was restored for the remaining 18 h post-dose. Graphic, Vehicle; ▪, 0.01 mg/kg; Graphic, 0.1 mg/kg; □, 1 mg/kg. *P < 0.0001, †P < 0.05, each vs. vehicle.

This Article

  1. Diabetes vol. 57 no. 6 1723-1729