Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

TABLE 1

In vitro inhibition of human and rat SGLT2 and SGLT1 by dapagliflozin and phlorizin

Human SGLT2 Human SGLT1 Rat SGLT2 Rat SGLT1
Dapagliflozin 1.12 ± 0.065 (n = 18) 1,391 ± 7 (n = 16) 3.0 ± 0.5 (n = 5) 620 ± 70 (n = 6)
Phlorizin 35.6 ± 4.2 (n = 11) 330 ± 50 (n = 10) 75 ± 8 (n = 4) 302 ± 30 (n = 4)
  • Data are mean EC50 ± SE (nmol/l).

This Article

  1. Diabetes vol. 57 no. 6 1723-1729