Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

TABLE 2

In vitro inhibition of human adipocyte GLUT activity by dapagliflozin, phlorizin, phloretin, and cytochalasin B (20 μmol/l)

No BSA added
4% BSA added
% Inhibition, basal % Inhibition, + insulin % Inhibition, basal % Inhibition, + insulin
Dapagliflozin 9 ± 1 (3) 8 ± 3 (3) 0 (1) 0 (1)
Phlorizin 10 (1) 12 (1) 11 (1) 5 (1)
Phloretin 78 (1) 79 (1) 77 (1) 77 (1)
Cytochalasin B 88 ± 2 (4) 89 ± 0.3 (4) 86 ± 1 (3) 88 ± 1 (3)
  • Data in parentheses are n. BSA, bovine serum albumin.

This Article

  1. Diabetes vol. 57 no. 6 1723-1729