Table of Contents

Perspectives in Diabetes

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- Reza Abdi,
- Paolo Fiorina,
- Chaker N. Adra,
- Mark Atkinson,
- and Mohamed H. Sayegh
Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes
Diabetes July 2008 57:1759-1767; doi:10.2337/db08-0180
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- Deborah A. Cohen
Neurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control
Diabetes July 2008 57:1768-1773; doi:10.2337/db08-0163
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- Carsten Schmitz-Peiffer and
- Trevor J. Biden
Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes
Diabetes July 2008 57:1774-1783; doi:10.2337/db07-1769

Commentaries

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- James A. Levine and
- Ronald M. Davis
The Pol-e-Pill Finally Arrives
Diabetes July 2008 57:1784-1785; doi:10.2337/db08-0108
Select this article
- Kevin D. Niswender and
- Bettina M. Beech
Obesity: Increasing Awareness of Novel Environmental Factors
Diabetes July 2008 57:1786-1787; doi:10.2337/db08-0527
Select this article
- Eddie A. James and
- William W. Kwok
Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes
Diabetes July 2008 57:1788-1789; doi:10.2337/db08-0530

New Methodologies and Databases

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- Eric D. Berglund,
- Candice Y. Li,
- Greg Poffenberger,
- Julio E. Ayala,
- Patrick T. Fueger,
- Shannon E. Willis,
- Marybeth M. Jewell,
- Alvin C. Powers,
- and David H. Wasserman
Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains
Diabetes July 2008 57:1790-1799; published ahead of print April 8, 2008, doi:10.2337/db07-1615

Metabolism

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- Rita Basu,
- Visvanathan Chandramouli,
- Betty Dicke,
- Bernard R. Landau,
- and Robert A. Rizza
Plasma C5 Glucose–to–²H₂O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis During Hyperinsulinemic-Euglycemic Clamps in Either Nondiabetic or Diabetic Humans
Diabetes July 2008 57:1800-1804; published ahead of print April 16, 2008, doi:10.2337/db08-0195

Signal Transduction

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- Zhong Q. Wang,
- William T. Cefalu,
- Xian H. Zhang,
- Yongmei Yu,
- Jianhua Qin,
- Leslie Son,
- Pamela M. Rogers,
- Nazar Mashtalir,
- Justin R. Bordelon,
- Jianping Ye,
- and Nikhil V. Dhurandhar
Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
Diabetes July 2008 57:1805-1813; published ahead of print April 16, 2008, doi:10.2337/db07-1313
Select this article
- Jen-Ying Deng,
- Po-Shiuan Hsieh,
- Jiung-Pang Huang,
- Long-Sheng Lu,
- and Li-Man Hung
Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
Diabetes July 2008 57:1814-1823; published ahead of print April 21, 2008, doi:10.2337/db07-1750

Obesity Studies

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- Liping Qiao,
- Chenhui Zou,
- Deneys R. van der Westhuyzen,
- and Jianhua Shao
Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism
Diabetes July 2008 57:1824-1833; published ahead of print March 28, 2008, doi:10.2337/db07-0435
Select this article
- Johan W.E. Jocken,
- Carsten Roepstorff,
- Gijs H. Goossens,
- Paula van der Baan,
- Marleen van Baak,
- Wim H.M. Saris,
- Bente Kiens,
- and Ellen E. Blaak
Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects: Effect of β-Adrenergic Stimulation
Diabetes July 2008 57:1834-1841; published ahead of print April 8, 2008, doi:10.2337/db07-0857
Select this article
- Chloé C. Féral,
- Jaap G. Neels,
- Christiane Kummer,
- Marina Slepak,
- Jerrold M. Olefsky,
- and Mark H. Ginsberg
Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity
Diabetes July 2008 57:1842-1851; published ahead of print April 21, 2008, doi:10.2337/db07-1751

Immunology and Transplantation

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- Matteo G. Levisetti,
- Danna M. Lewis,
- Anish Suri,
- and Emil R. Unanue
Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice
Diabetes July 2008 57:1852-1860; published ahead of print April 8, 2008, doi:10.2337/db08-0068
Select this article
- Chia-Jen Wang,
- Feng-Cheng Chou,
- Chi-Hong Chu,
- Jen-Chine Wu,
- Shih-Hua Lin,
- Deh-Ming Chang,
- and Huey-Kang Sytwu
Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models
Diabetes July 2008 57:1861-1869; published ahead of print April 16, 2008, doi:10.2337/db07-1260
Select this article
- Johan Olerud,
- Magnus Johansson,
- Jack Lawler,
- Nils Welsh,
- and Per-Ola Carlsson
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
Diabetes July 2008 57:1870-1877; published ahead of print April 16, 2008, doi:10.2337/db07-0724
Select this article
- George Vlad,
- Vivette D. D'Agati,
- Qing-Yin Zhang,
- Zhuoru Liu,
- Eric K. Ho,
- Thalachallour Mohanakumar,
- Mark A. Hardy,
- Raffaello Cortesini,
- and Nicole Suciu-Foca
Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice
Diabetes July 2008 57:1878-1886; published ahead of print April 16, 2008, doi:10.2337/db08-0054

Islet Studies

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- Melkam Kebede,
- Jenny Favaloro,
- Jenny E. Gunton,
- D. Ross Laybutt,
- Margaret Shaw,
- Nicole Wong,
- Barbara C. Fam,
- Kathryn Aston-Mourney,
- Christian Rantzau,
- Anthony Zulli,
- Joseph Proietto,
- and Sofianos Andrikopoulos
Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion: A New Mechanism for Fat-Induced Impairment of β-Cell Function
Diabetes July 2008 57:1887-1895; published ahead of print March 28, 2008, doi:10.2337/db07-1326
Select this article
- Dariush Mokhtari,
- Jason W. Myers,
- and Nils Welsh
MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH₂-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells
Diabetes July 2008 57:1896-1904; published ahead of print April 16, 2008, doi:10.2337/db07-1670

Pathophysiology

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- Paolo Rossetti,
- Francesca Porcellati,
- Natalia Busciantella Ricci,
- Paola Candeloro,
- Patrizia Cioli,
- K. Sreekumaran Nair,
- Fausto Santeusanio,
- Geremia B. Bolli,
- and Carmine G. Fanelli
Effect of Oral Amino Acids on Counterregulatory Responses and Cognitive Function During Insulin-Induced Hypoglycemia in Nondiabetic and Type 1 Diabetic People
Diabetes July 2008 57:1905-1917; published ahead of print April 4, 2008, doi:10.2337/db08-0276
Select this article
- José Manuel Fernández-Real,
- José María Moreno,
- and Wifredo Ricart
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload
Diabetes July 2008 57:1918-1925; published ahead of print April 21, 2008, doi:10.2337/db08-0041
Select this article
- Kristen M. Picha,
- Mark R. Cunningham,
- Daniel J. Drucker,
- Ashok Mathur,
- Tatiana Ort,
- Michael Scully,
- Avery Soderman,
- Tracy Spinka-Doms,
- Vedrana Stojanovic-Susulic,
- Beth Ann Thomas,
- and Karyn T. O'Neil
Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
Diabetes July 2008 57:1926-1934; published ahead of print April 21, 2008, doi:10.2337/db07-1775
Select this article
- Maha Abdulhadi-Atwan,
- Jeremy D. Bushman,
- Sharona Tornovsky-Babaey,
- Avital Perry,
- Abdulsalam Abu-Libdeh,
- Benjamin Glaser,
- Show-Ling Shyng,
- and David H. Zangen
Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence
Diabetes July 2008 57:1935-1940; published ahead of print April 4, 2008, doi:10.2337/db08-0159

Complications

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- Loredana G. Bucciarelli,
- Radha Ananthakrishnan,
- Yuying C. Hwang,
- Michiyo Kaneko,
- Fei Song,
- David R. Sell,
- Christopher Strauch,
- Vincent M. Monnier,
- Shi Fang Yan,
- Ann Marie Schmidt,
- and Ravichandran Ramasamy
RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium
Diabetes July 2008 57:1941-1951; published ahead of print April 16, 2008, doi:10.2337/db07-0326
Select this article
- Julia V. Busik,
- Susanne Mohr,
- and Maria B. Grant
Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators
Diabetes July 2008 57:1952-1965; published ahead of print April 16, 2008, doi:10.2337/db07-1520
Select this article
- Gabriella Gruden,
- Graziella Bruno,
- Nish Chaturvedi,
- Davina Burt,
- Casper Schalkwijk,
- Silvia Pinach,
- Coen D. Stehouwer,
- Daniel R. Witte,
- John H. Fuller,
- Paolo Cavallo Perin,
- and the EURODIAB Prospective Complications Study Group
Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study: A Novel Circulating Marker for Diabetic Neuropathy
Diabetes July 2008 57:1966-1970; published ahead of print April 4, 2008, doi:10.2337/db08-0009

Genetics

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- Elliot S. Stolerman,
- Alisa K. Manning,
- Jarred B. McAteer,
- Josée Dupuis,
- Caroline S. Fox,
- L. Adrienne Cupples,
- James B. Meigs,
- and Jose C. Florez
Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study
Diabetes July 2008 57:1971-1977; published ahead of print April 21, 2008, doi:10.2337/db08-0266
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- Lorna W. Harries,
- Melissa J. Sloman,
- Elizabeth A.C. Sellers,
- Andrew T. Hattersley,
- and Sian Ellard
Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts
Diabetes July 2008 57:1978-1982; published ahead of print April 14, 2008, doi:10.2337/db07-1633
Select this article
- Hui-Qi Qu,
- Struan F.A. Grant,
- Jonathan P. Bradfield,
- Cecilia Kim,
- Edward Frackelton,
- Hakon Hakonarson,
- and Constantin Polychronakos
Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes
Diabetes July 2008 57:1983-1986; published ahead of print April 21, 2008, doi:10.2337/db08-0270
Select this article
- Amanda F. Marvelle,
- Leslie A. Lange,
- Li Qin,
- Linda S. Adair,
- and Karen L. Mohlke
Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
Diabetes July 2008 57:1987-1991; published ahead of print April 21, 2008, doi:10.2337/db07-1700
Select this article
- Konsta Duesing,
- Ghazaleh Fatemifar,
- Guillaume Charpentier,
- Michel Marre,
- Jean Tichet,
- Serge Hercberg,
- Beverley Balkau,
- Philippe Froguel,
- and Fernando Gibson
Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians
Diabetes July 2008 57:1992-1996; published ahead of print April 22, 2008, doi:10.2337/db07-1789

Perspectives in Diabetes

Immunomodulation by Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Type 1 Diabetes

Neurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

Commentaries

The Pol-e-Pill Finally Arrives

Obesity: Increasing Awareness of Novel Environmental Factors

Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes

New Methodologies and Databases

Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains

Metabolism

Plasma C5 Glucose–to–2H2O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis During Hyperinsulinemic-Euglycemic Clamps in Either Nondiabetic or Diabetic Humans

Signal Transduction

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways

Obesity Studies

Adiponectin Reduces Plasma Triglyceride by Increasing VLDL Triglyceride Catabolism

Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects: Effect of β-Adrenergic Stimulation

Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity

Immunology and Transplantation

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice

Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets

Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice

Islet Studies

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion: A New Mechanism for Fat-Induced Impairment of β-Cell Function

MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH2-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells

Pathophysiology

Effect of Oral Amino Acids on Counterregulatory Responses and Cognitive Function During Insulin-Induced Hypoglycemia in Nondiabetic and Type 1 Diabetic People

Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence

Complications

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators

Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study: A Novel Circulating Marker for Diabetic Neuropathy

Genetics

Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study

Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes

Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians

This Issue

Current Issue

Plasma C5 Glucose–to–²H₂O Ratio Does Not Provide an Accurate Assessment of Gluconeogenesis During Hyperinsulinemic-Euglycemic Clamps in Either Nondiabetic or Diabetic Humans

MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH₂-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells