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Table of Contents

August 2008; 57 (8)

Metabolism

    • Patrice Dallaire,
    • Kerstin Bellmann,
    • Mathieu Laplante,
    • Stéphanie Gélinas,
    • Carolina Centeno-Baez,
    • Patrice Penfornis,
    • Marie-Line Peyot,
    • Martin G. Latour,
    • Julien Lamontagne,
    • Maria E. Trujillo,
    • Philipp E. Scherer,
    • Marc Prentki,
    • Yves Deshaies,
    • and André Marette

    Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor-γ Agonism

    Diabetes August 2008 57:1999-2011; published ahead of print May 5, 2008, doi:10.2337/db08-0540
    • Santhosh Satapati,
    • TianTeng He,
    • Takeshi Inagaki,
    • Matthew Potthoff,
    • Matthew E. Merritt,
    • Victoria Esser,
    • David J. Mangelsdorf,
    • Steven A. Kliewer,
    • Jeffrey D. Browning,
    • and Shawn C. Burgess

    Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism

    Diabetes August 2008 57:2012-2021; published ahead of print May 9, 2008, doi:10.2337/db08-0226
    • Susan Sam,
    • Steven Haffner,
    • Michael H. Davidson,
    • Ralph B. D'Agostino, Sr.,
    • Steven Feinstein,
    • George Kondos,
    • Alfonso Perez,
    • and Theodore Mazzone

    Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes

    Diabetes August 2008 57:2022-2027; published ahead of print May 9, 2008, doi:10.2337/db08-0157
    • Laura Tedesco,
    • Alessandra Valerio,
    • Cristina Cervino,
    • Annalisa Cardile,
    • Claudio Pagano,
    • Roberto Vettor,
    • Renato Pasquali,
    • Michele O. Carruba,
    • Giovanni Marsicano,
    • Beat Lutz,
    • Uberto Pagotto,
    • and Enzo Nisoli

    Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

    Diabetes August 2008 57:2028-2036; published ahead of print May 13, 2008, doi:10.2337/db07-1623
    • Ming Bell,
    • Hong Wang,
    • Hui Chen,
    • John C. McLenithan,
    • Da-Wei Gong,
    • Rong-Zee Yang,
    • Daozhan Yu,
    • Susan K. Fried,
    • Michael J. Quon,
    • Constantine Londos,
    • and Carole Sztalryd

    Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

    Diabetes August 2008 57:2037-2045; published ahead of print May 16, 2008, doi:10.2337/db07-1383
    • Darleen A. Sandoval,
    • Didier Bagnol,
    • Stephen C. Woods,
    • David A. D'Alessio,
    • and Randy J. Seeley

    Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

    Diabetes August 2008 57:2046-2054; published ahead of print May 16, 2008, doi:10.2337/db07-1824
    • Victoria A. Payne,
    • Neil Grimsey,
    • Antoinette Tuthill,
    • Sam Virtue,
    • Sarah L. Gray,
    • Edoardo Dalla Nora,
    • Robert K. Semple,
    • Stephen O'Rahilly,
    • and Justin J. Rochford

    The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

    Diabetes August 2008 57:2055-2060; published ahead of print May 5, 2008, doi:10.2337/db08-0184
    • Rachel Ross,
    • Penny Y.T. Wang,
    • Madhu Chari,
    • Carol K.L. Lam,
    • Liora Caspi,
    • Hiraku Ono,
    • Evan D. Muse,
    • Xiaosong Li,
    • Roger Gutierrez-Juarez,
    • Peter E. Light,
    • Gary J. Schwartz,
    • Luciano Rossetti,
    • and Tony K.T. Lam

    Hypothalamic Protein Kinase C Regulates Glucose Production

    Diabetes August 2008 57:2061-2065; published ahead of print May 28, 2008, doi:10.2337/db08-0206

Signal Transduction

    • Reginald L. Austin,
    • Anna Rune,
    • Karim Bouzakri,
    • Juleen R. Zierath,
    • and Anna Krook

    siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle

    Diabetes August 2008 57:2066-2073; published ahead of print April 28, 2008, doi:10.2337/db07-0763
    • Nora Klöting,
    • Linda Koch,
    • Thomas Wunderlich,
    • Matthias Kern,
    • Karen Ruschke,
    • Wilhelm Krone,
    • Jens C. Brüning,
    • and Matthias Blüher

    Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth

    Diabetes August 2008 57:2074-2082; published ahead of print April 28, 2008, doi:10.2337/db07-1538
    • Naoki Kumashiro,
    • Yoshifumi Tamura,
    • Toyoyoshi Uchida,
    • Takeshi Ogihara,
    • Yoshio Fujitani,
    • Takahisa Hirose,
    • Hideki Mochizuki,
    • Ryuzo Kawamori,
    • and Hirotaka Watada

    Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor γ Coactivator-1α in Hepatic Insulin Resistance

    Diabetes August 2008 57:2083-2091; published ahead of print May 16, 2008, doi:10.2337/db08-0144

Obesity Studies

    • Ling Shen,
    • Patrick Tso,
    • Stephen C. Woods,
    • Deborah J. Clegg,
    • Kyna L. Barber,
    • Katherine Carey,
    • and Min Liu

    Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats

    Diabetes August 2008 57:2092-2098; published ahead of print June 16, 2008, doi:10.2337/db08-0291

Immunology and Transplantation

    • Li Li,
    • Bo Wang,
    • Jeffrey A. Frelinger,
    • and Roland Tisch

    T-Cell Promiscuity in Autoimmune Diabetes

    Diabetes August 2008 57:2099-2106; published ahead of print May 20, 2008, doi:10.2337/db08-0383
    • Gilles Besin,
    • Simon Gaudreau,
    • Michaël Ménard,
    • Chantal Guindi,
    • Gilles Dupuis,
    • and Abdelaziz Amrani

    Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes

    Diabetes August 2008 57:2107-2117; published ahead of print May 13, 2008, doi:10.2337/db08-0171
    • Junyan Han,
    • Jinxin Zhong,
    • Wenzhong Wei,
    • Ying Wang,
    • Yafei Huang,
    • Ping Yang,
    • Sharad Purohit,
    • Zheng Dong,
    • Mong-Heng Wang,
    • Jin-Xiong She,
    • Feili Gong,
    • David M. Stern,
    • and Cong-Yi Wang

    Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

    Diabetes August 2008 57:2118-2127; published ahead of print May 13, 2008, doi:10.2337/db07-1499
    • Babak Movahedi,
    • Conny Gysemans,
    • Daniel Jacobs-Tulleneers-Thevissen,
    • Chantal Mathieu,
    • and Daniel Pipeleers

    Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor

    Diabetes August 2008 57:2128-2136; published ahead of print May 20, 2008, doi:10.2337/db07-1705

Islet Studies

    • Zhao V. Wang,
    • James Mu,
    • Todd D. Schraw,
    • Laurent Gautron,
    • Joel K. Elmquist,
    • Bei B. Zhang,
    • Michael Brownlee,
    • and Philipp E. Scherer

    PANIC-ATTAC: A Mouse Model for Inducible and Reversible β-Cell Ablation

    Diabetes August 2008 57:2137-2148; published ahead of print May 9, 2008, doi:10.2337/db07-1631

Pathophysiology

    • Ricardo Rodríguez-Calvo,
    • Lucía Serrano,
    • Teresa Coll,
    • Norman Moullan,
    • Rosa M. Sánchez,
    • Manuel Merlos,
    • Xavier Palomer,
    • Juan C. Laguna,
    • Liliane Michalik,
    • Walter Wahli,
    • and Manuel Vázquez-Carrera

    Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2

    Diabetes August 2008 57:2149-2157; published ahead of print April 28, 2008, doi:10.2337/db08-0176
    • Lin Zhang,
    • Mark B. Cannell,
    • Anthony R.J. Phillips,
    • Garth J.S. Cooper,
    • and Marie-Louise Ward

    Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy

    Diabetes August 2008 57:2158-2166; published ahead of print May 20, 2008, doi:10.2337/db08-0140

Complications

    • Touria Nehiri,
    • Jean-Paul Duong Van Huyen,
    • Mélanie Viltard,
    • Céline Fassot,
    • Didier Heudes,
    • Nicole Freund,
    • Georges Deschênes,
    • Pascal Houillier,
    • Patrick Bruneval,
    • and Martine Lelièvre-Pégorier

    Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring

    Diabetes August 2008 57:2167-2175; published ahead of print April 28, 2008, doi:10.2337/db07-0780
    • Kustaa Hietala,
    • Carol Forsblom,
    • Paula Summanen,
    • and Per-Henrik Groop

    Heritability of Proliferative Diabetic Retinopathy

    Diabetes August 2008 57:2176-2180; published ahead of print April 28, 2008, doi:10.2337/db07-1495
    • Young-Hee Kim,
    • Yoon-Sook Kim,
    • Chang-Hwan Park,
    • In-Yong Chung,
    • Ji-Myong Yoo,
    • Jae-Geun Kim,
    • Byung-Ju Lee,
    • Sang-Soo Kang,
    • Gyeong-Jae Cho,
    • and Wan-Sung Choi

    Protein Kinase C-δ Mediates Neuronal Apoptosis in the Retinas of Diabetic Rats via the Akt Signaling Pathway

    Diabetes August 2008 57:2181-2190; published ahead of print April 28, 2008, doi:10.2337/db07-1431
    • Toshihide Kurihara,
    • Yoko Ozawa,
    • Norihiro Nagai,
    • Kei Shinoda,
    • Kousuke Noda,
    • Yutaka Imamura,
    • Kazuo Tsubota,
    • Hideyuki Okano,
    • Yuichi Oike,
    • and Susumu Ishida

    Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina

    Diabetes August 2008 57:2191-2198; published ahead of print May 16, 2008, doi:10.2337/db07-1281

Pharmacology and Therapeutics

    • Alicia G. Gómez-Valadés,
    • Andrés Méndez-Lucas,
    • Anna Vidal-Alabró,
    • Francese X. Blasco,
    • Miguel Chillon,
    • Ramon Bartrons,
    • Jordi Bermúdez,
    • and José C. Perales

    Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

    Diabetes August 2008 57:2199-2210; published ahead of print April 28, 2008, doi:10.2337/db07-1087
    • Carina P. Tan,
    • Yue Feng,
    • Yun-Ping Zhou,
    • George J. Eiermann,
    • Aleksandr Petrov,
    • Changyou Zhou,
    • Songnian Lin,
    • Gino Salituro,
    • Peter Meinke,
    • Ralph Mosley,
    • Taro E. Akiyama,
    • Monica Einstein,
    • Sanjeev Kumar,
    • Joel P. Berger,
    • Sander G. Mills,
    • Nancy A. Thornberry,
    • Lihu Yang,
    • and Andrew D. Howard

    Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

    Diabetes August 2008 57:2211-2219; published ahead of print May 13, 2008, doi:10.2337/db08-0130

Genetics

    • Joshua P. Lewis,
    • Nicholette D. Palmer,
    • Pamela J. Hicks,
    • Michele M. Sale,
    • Carl D. Langefeld,
    • Barry I. Freedman,
    • Jasmin Divers,
    • and Donald W. Bowden

    Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies

    Diabetes August 2008 57:2220-2225; published ahead of print April 28, 2008, doi:10.2337/db07-1319
    • Maggie C.Y. Ng,
    • Kyong Soo Park,
    • Bermseok Oh,
    • Claudia H.T. Tam,
    • Young Min Cho,
    • Hyoung Doo Shin,
    • Vincent K.L. Lam,
    • Ronald C.W. Ma,
    • Wing Yee So,
    • Yoon Shin Cho,
    • Hyung-Lae Kim,
    • Hong Kyu Lee,
    • Juliana C.N. Chan,
    • and Nam H. Cho

    Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

    Diabetes August 2008 57:2226-2233; published ahead of print May 9, 2008, doi:10.2337/db07-1583
    • Michelle Goldsworthy,
    • Alison Hugill,
    • Helen Freeman,
    • Emma Horner,
    • Kenju Shimomura,
    • Debora Bogani,
    • Guido Pieles,
    • Vesna Mijat,
    • Ruth Arkell,
    • Shoumo Bhattacharya,
    • Frances M. Ashcroft,
    • and Roger D. Cox

    Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

    Diabetes August 2008 57:2234-2244; published ahead of print May 13, 2008, doi:10.2337/db07-0337
    • Yi-Cheng Chang,
    • Pi-Hua Liu,
    • Wei-Jei Lee,
    • Tien-Jyun Chang,
    • Yi-Der Jiang,
    • Hung-Yuan Li,
    • Shan-Shan Kuo,
    • Kuang-Chin Lee,
    • and Lee-Ming Chuang

    Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

    Diabetes August 2008 57:2245-2252; published ahead of print May 16, 2008, doi:10.2337/db08-0377
    • Martine Vaxillaire,
    • Christine Cavalcanti-Proença,
    • Aurélie Dechaume,
    • Jean Tichet,
    • Michel Marre,
    • Beverley Balkau,
    • and Philippe Froguel

    The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

    Diabetes August 2008 57:2253-2257; published ahead of print June 12, 2008, doi:10.2337/db07-1807
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This Issue

August 2008; 57 (8)
  1. Metabolism
  2. Signal Transduction
  3. Obesity Studies
  4. Immunology and Transplantation
  5. Islet Studies
  6. Pathophysiology
  7. Complications
  8. Pharmacology and Therapeutics
  9. Genetics

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