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Table of Contents

January 2009; 58 (1)

Editorial

    • R. Paul Robertson

    ADA Research Funding in 2009: Where Will We Be?

    Diabetes January 2009 58:1; doi:10.2337/db08-1395

Online Letters

    • Jihane Romanos and
    • Cisca Wijmenga

    Comment on: Barker et al. (2008) Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Diabetes 57:3152–3155, 2008

    Diabetes January 2009 58:e1; doi:10.2337/db08-1312
    • Jennifer M. Barker,
    • Taylor M. Triolo,
    • and George S. Eisenbarth

    Response to Comment on: Barker et al. (2008) Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Diabetes 57:3152–3155, 2008

    Diabetes January 2009 58:e2; doi:10.2337/db08-1386
    • Andrzej Bartke and
    • John Kopchick

    Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082

    Diabetes January 2009 58:e3; doi:10.2337/db08-1308
    • Jens C. Brüning and
    • Matthias Blüher

    Response to Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082

    Diabetes January 2009 58:e4; doi:10.2337/db08-1442

OSA Lecture 2008

    • Matthias von Herrath

    Can We Learn From Viruses How to Prevent Type 1 Diabetes?: The Role of Viral Infections in the Pathogenesis of Type 1 Diabetes and the Development of Novel Combination Therapies

    Diabetes January 2009 58:2-11; doi:10.2337/db08-9027

Commentaries

    • Roland Tisch and
    • Bo Wang

    Role of Plasmacytoid Dendritic Cells in Type 1 Diabetes: Friend or Foe?

    Diabetes January 2009 58:12-13; doi:10.2337/db08-1341
    • Paul M. Stewart and
    • Jeremy W. Tomlinson

    Selective Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 for Patients With Metabolic Syndrome: Is the Target Liver, Fat, or Both?

    Diabetes January 2009 58:14-15; doi:10.2337/db08-1404
    • Matthew J. Watt and
    • Edward W. Kraegen

    Fat Partitioning and Insulin Sensitivity: Robbing Peter to Pay Paul?

    Diabetes January 2009 58:16-17; doi:10.2337/db08-1466
    • Loranne Agius

    Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks

    Diabetes January 2009 58:18-20; doi:10.2337/db08-1470
    • Casey M. Donovan and
    • MaryAnn Bohland

    Hypoglycemic Detection at the Portal Vein: Absent in Humans or Yet to Be Elucidated?

    Diabetes January 2009 58:21-23; doi:10.2337/db08-1437
    • Clive Wasserfall and
    • Mark A. Atkinson

    Taking a Daily Vitamin to Prevent Type 1 Diabetes?

    Diabetes January 2009 58:24-25; doi:10.2337/db08-1479
    • Kyle D. Copps and
    • Morris F. White

    Breathing Room: The (Un)Natural History of Adipose Microhypoxia and Insulin Resistance

    Diabetes January 2009 58:26-27; doi:10.2337/db08-1517
    • Douglas R. Cavener

    Sleeping Beauty, Awake! Regulation of Insulin Gene Expression by Methylation of Histone H3

    Diabetes January 2009 58:28-29; doi:10.2337/db08-1520

New Methodologies and Databases

    • Dustin S. Hittel,
    • Jason R. Berggren,
    • Jane Shearer,
    • Kristen Boyle,
    • and Joseph A. Houmard

    Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women

    Diabetes January 2009 58:30-38; published ahead of print October 3, 2008, doi:10.2337/db08-0943

Metabolism

    • Rita Basu,
    • Ananda Basu,
    • Meagan Grudzien,
    • Paul Jung,
    • Peer Jacobson,
    • Michael Johnson,
    • Ravinder Singh,
    • Michael Sarr,
    • and Robert A. Rizza

    Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans

    Diabetes January 2009 58:39-45; published ahead of print October 13, 2008, doi:10.2337/db08-1079
    • Roland H. Stimson,
    • Jonas Andersson,
    • Ruth Andrew,
    • Doris N. Redhead,
    • Fredrik Karpe,
    • Peter C. Hayes,
    • Tommy Olsson,
    • and Brian R. Walker

    Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans

    Diabetes January 2009 58:46-53; published ahead of print October 13, 2008, doi:10.2337/db08-0969
    • Rasmus Ribel-Madsen,
    • Martin Friedrichsen,
    • Allan Vaag,
    • and Pernille Poulsen

    Retinol-Binding Protein 4 in Twins: Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action

    Diabetes January 2009 58:54-60; published ahead of print October 13, 2008, doi:10.2337/db08-1019
    • Yuichi Ikegami,
    • Kouichi Inukai,
    • Kenta Imai,
    • Yasushi Sakamoto,
    • Hideki Katagiri,
    • Susumu Kurihara,
    • Takuya Awata,
    • and Shigehiro Katayama

    Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells

    Diabetes January 2009 58:61-70; published ahead of print October 17, 2008, doi:10.2337/db07-0690
    • Weili Xu,
    • Chengxuan Qiu,
    • Margaret Gatz,
    • Nancy L. Pedersen,
    • Boo Johansson,
    • and Laura Fratiglioni

    Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study

    Diabetes January 2009 58:71-77; published ahead of print October 24, 2008, doi:10.2337/db08-0586
    • Tracy P. Torres,
    • ReEtta L. Catlin,
    • Robert Chan,
    • Yuka Fujimoto,
    • Noriyasu Sasaki,
    • Richard L. Printz,
    • Christopher B. Newgard,
    • and Masakazu Shiota

    Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats

    Diabetes January 2009 58:78-86; published ahead of print October 24, 2008, doi:10.2337/db08-1119
    • Arnold Leckstrom,
    • Eun Ran Kim,
    • Davie Wong,
    • and Tooru M. Mizuno

    Xenin, a Gastrointestinal Peptide, Regulates Feeding Independent of the Melanocortin Signaling Pathway

    Diabetes January 2009 58:87-94; published ahead of print November 4, 2008, doi:10.2337/db08-0260

Signal Transduction

    • Claire Regazzetti,
    • Pascal Peraldi,
    • Thierry Grémeaux,
    • Rosanna Najem-Lendom,
    • Issam Ben-Sahra,
    • Mireille Cormont,
    • Frédéric Bost,
    • Yannick Le Marchand-Brustel,
    • Jean-François Tanti,
    • and Sophie Giorgetti-Peraldi

    Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

    Diabetes January 2009 58:95-103; published ahead of print November 4, 2008, doi:10.2337/db08-0457

Obesity Studies

    • Ping Jiao,
    • Qiu Chen,
    • Suketu Shah,
    • Jing Du,
    • Bo Tao,
    • Iphigenia Tzameli,
    • Weiqun Yan,
    • and Haiyan Xu

    Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes: Involvement of Nuclear Factor-κB and c-Jun NH2-Terminal Kinase Pathways

    Diabetes January 2009 58:104-115; published ahead of print October 3, 2008, doi:10.2337/db07-1344
    • Adeline Bertola,
    • Vanessa Deveaux,
    • Stéphanie Bonnafous,
    • Déborah Rousseau,
    • Rodolphe Anty,
    • Abdelilah Wakkach,
    • Moncef Dahman,
    • Joan Tordjman,
    • Karine Clément,
    • Siobhán E. McQuaid,
    • Keith N. Frayn,
    • Pierre-Michel Huet,
    • Jean Gugenheim,
    • Sophie Lotersztajn,
    • Yannick Le Marchand-Brustel,
    • Albert Tran,
    • and Philippe Gual

    Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity

    Diabetes January 2009 58:125-133; published ahead of print October 24, 2008, doi:10.2337/db08-0400
    • Wolfgang Lieb,
    • Michael J. Pencina,
    • Katherine J. Lanier,
    • Geoffrey H. Tofler,
    • Daniel Levy,
    • Caroline S. Fox,
    • Thomas J. Wang,
    • Ralph B. D'Agostino, Sr.,
    • and Ramachandran S. Vasan

    Association of Parental Obesity With Concentrations of Select Systemic Biomarkers in Nonobese Offspring: The Framingham Heart Study

    Diabetes January 2009 58:134-137; published ahead of print October 17, 2008, doi:10.2337/db08-0918

Original Article

Obesity Studies

    • Hong Wang,
    • Leslie A. Knaub,
    • Dalan R. Jensen,
    • Dae Young Jung,
    • Eun-Gyoung Hong,
    • Hwi-Jin Ko,
    • Alison M. Coates,
    • Ira J. Goldberg,
    • Becky A. de la Houssaye,
    • Rachel C. Janssen,
    • Carrie E. McCurdy,
    • Shaikh M. Rahman,
    • Cheol Soo Choi,
    • Gerald I. Shulman,
    • Jason K. Kim,
    • Jacob E. Friedman,
    • and Robert H. Eckel

    Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues

    Diabetes January 2009 58:116-124; published ahead of print October 24, 2008, doi:10.2337/db07-1839

Immunology and Transplantation

    • Jennifer S. Allen,
    • Karl Pang,
    • Ania Skowera,
    • Richard Ellis,
    • Chloe Rackham,
    • Biliana Lozanoska-Ochser,
    • Timothy Tree,
    • R. David G. Leslie,
    • Jennifer M. Tremble,
    • Colin M. Dayan,
    • and Mark Peakman

    Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

    Diabetes January 2009 58:138-145; published ahead of print October 3, 2008, doi:10.2337/db08-0964
    • Yang-Hau Van,
    • Wen-Hui Lee,
    • Serina Ortiz,
    • Mi-Heon Lee,
    • Han-Jun Qin,
    • and Chih-Pin Liu

    All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-γ–Producing T-cells Without Affecting Th17 Cells

    Diabetes January 2009 58:146-155; published ahead of print November 4, 2008, doi:10.2337/db08-1154
    • Yang D. Dai,
    • Idania G. Marrero,
    • Philippe Gros,
    • Habib Zaghouani,
    • Linda S. Wicker,
    • and Eli E. Sercarz

    Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

    Diabetes January 2009 58:156-164; published ahead of print November 4, 2008, doi:10.2337/db07-1608
    • Julie Mangada,
    • Todd Pearson,
    • Michael A. Brehm,
    • Linda S. Wicker,
    • Laurence B. Peterson,
    • Leonard D. Shultz,
    • David V. Serreze,
    • Aldo A. Rossini,
    • and Dale L. Greiner

    Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

    Diabetes January 2009 58:165-173; published ahead of print November 4, 2008, doi:10.2337/db08-0275

Islet Studies

    • Etsuko Hisanaga,
    • Masahiro Nagasawa,
    • Kohjiro Ueki,
    • Rohit N. Kulkarni,
    • Masatomo Mori,
    • and Itaru Kojima

    Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

    Diabetes January 2009 58:174-184; published ahead of print November 4, 2008, doi:10.2337/db08-0862
    • Tye G. Deering,
    • Takeshi Ogihara,
    • Anthony P. Trace,
    • Bernhard Maier,
    • and Raghavendra G. Mirmira

    Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

    Diabetes January 2009 58:185-193; published ahead of print November 4, 2008, doi:10.2337/db08-1150

Pathophysiology

    • Paolo Rossetti,
    • Francesca Porcellati,
    • Paola Lucidi,
    • Natalia Busciantella Ricci,
    • Paola Candeloro,
    • Patrizia Cioli,
    • Fausto Santeusanio,
    • Geremia B. Bolli,
    • and Carmine G. Fanelli

    Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans

    Diabetes January 2009 58:194-202; published ahead of print October 13, 2008, doi:10.2337/db08-0641
    • Anna Kotronen,
    • Tuulikki Seppänen-Laakso,
    • Jukka Westerbacka,
    • Tuula Kiviluoto,
    • Johanna Arola,
    • Anna-Liisa Ruskeepää,
    • Matej Orešič,
    • and Hannele Yki-Järvinen

    Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

    Diabetes January 2009 58:203-208; published ahead of print October 24, 2008, doi:10.2337/db08-1074

Complications

    • Pilar Jiménez-Quevedo,
    • Nobuaki Suzuki,
    • Cecilia Corros,
    • Cruz Ferrer,
    • Dominick J. Angiolillo,
    • Fernando Alfonso,
    • Rosana Hernández-Antolín,
    • Camino Bañuelos,
    • Javier Escaned,
    • Cristina Fernández,
    • Marco Costa,
    • Carlos Macaya,
    • Theodore Bass,
    • and Manel Sabaté

    Vessel Shrinkage as a Sign of Atherosclerosis Progression in Type 2 Diabetes: A Serial Intravascular Ultrasound Analysis

    Diabetes January 2009 58:209-214; published ahead of print October 1, 2008, doi:10.2337/db08-0376
    • Ryoichi Arita,
    • Yasuaki Hata,
    • Shintaro Nakao,
    • Takeshi Kita,
    • Muneki Miura,
    • Shuhei Kawahara,
    • Souska Zandi,
    • Lama Almulki,
    • Faryan Tayyari,
    • Hiroaki Shimokawa,
    • Ali Hafezi-Moghadam,
    • and Tatsuro Ishibashi

    Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage

    Diabetes January 2009 58:215-226; published ahead of print October 7, 2008, doi:10.2337/db08-0762
    • Mamta Kanwar and
    • Renu A. Kowluru

    Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy

    Diabetes January 2009 58:227-234; published ahead of print October 13, 2008, doi:10.2337/db08-1025

Pharmacology & Therapeutics

    • Massimo Collino,
    • Manuela Aragno,
    • Sara Castiglia,
    • Chiara Tomasinelli,
    • Christoph Thiemermann,
    • Giuseppe Boccuzzi,
    • and Roberto Fantozzi

    Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β

    Diabetes January 2009 58:235-242; published ahead of print October 7, 2008, doi:10.2337/db08-0691
    • Dale S. Edgerton,
    • Kathryn M.S. Johnson,
    • Doss W. Neal,
    • Melanie Scott,
    • Charles H. Hobbs,
    • Xia Zhang,
    • Alokesh Duttaroy,
    • and Alan D. Cherrington

    Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

    Diabetes January 2009 58:243-249; published ahead of print October 7, 2008, doi:10.2337/db08-0515
    • Jing Xu,
    • David J. Lloyd,
    • Clarence Hale,
    • Shanaka Stanislaus,
    • Michelle Chen,
    • Glenn Sivits,
    • Steven Vonderfecht,
    • Randy Hecht,
    • Yue-Sheng Li,
    • Richard A. Lindberg,
    • Jin-Long Chen,
    • Dae Young Jung,
    • Zhiyou Zhang,
    • Hwi-Jin Ko,
    • Jason K. Kim,
    • and Murielle M. Véniant

    Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

    Diabetes January 2009 58:250-259; published ahead of print October 7, 2008, doi:10.2337/db08-0392

Genetics

    • Michèle M. Sale,
    • Lingyi Lu,
    • Ida J. Spruill,
    • Jyotika K. Fernandes,
    • Kerry H. Lok,
    • Jasmin Divers,
    • Carl D. Langefeld,
    • and W. Timothy Garvey

    Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

    Diabetes January 2009 58:260-267; published ahead of print October 3, 2008, doi:10.2337/db08-0198
    • Steven C. Elbein,
    • Swapan K. Das,
    • D. Michael Hallman,
    • Craig L. Hanis,
    • and Sandra J. Hasstedt

    Genome-Wide Linkage and Admixture Mapping of Type 2 Diabetes in African American Families From the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort

    Diabetes January 2009 58:268-274; published ahead of print October 7, 2008, doi:10.2337/db08-0931
    • Lu Qi,
    • Nader Rifai,
    • and Frank B. Hu

    Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women

    Diabetes January 2009 58:275-278; published ahead of print October 13, 2008, doi:10.2337/db08-0968
    • Dawn K. Coletta,
    • Jennifer Schneider,
    • Shirley L. Hu,
    • Thomas D. Dyer,
    • Sobha Puppala,
    • Vidya S. Farook,
    • Rector Arya,
    • Donna M. Lehman,
    • John Blangero,
    • Ralph A. DeFronzo,
    • Ravindranath Duggirala,
    • and Christopher P. Jenkinson

    Genome-Wide Linkage Scan for Genes Influencing Plasma Triglyceride Levels in the Veterans Administration Genetic Epidemiology Study

    Diabetes January 2009 58:279-284; published ahead of print October 17, 2008, doi:10.2337/db08-0491
    • Yu Yan,
    • Kari E. North,
    • Christie M. Ballantyne,
    • Frederick L. Brancati,
    • Lloyd E. Chambless,
    • Nora Franceschini,
    • Gerardo Heiss,
    • Anna Kottgen,
    • James S. Pankow,
    • Elizabeth Selvin,
    • Suzanne L. West,
    • and Eric Boerwinkle

    Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Context-Specific Risk of Type 2 Diabetes in African American and Caucasian Adults: The Atherosclerosis Risk in Communities Study

    Diabetes January 2009 58:285-289; published ahead of print October 17, 2008, doi:10.2337/db08-0569
    • Struan F.A. Grant,
    • Hui-Qi Qu,
    • Jonathan P. Bradfield,
    • Luc Marchand,
    • Cecilia E. Kim,
    • Joseph T. Glessner,
    • Rosemarie Grabs,
    • Shayne P. Taback,
    • Edward C. Frackelton,
    • Andrew W. Eckert,
    • Kiran Annaiah,
    • Margaret L. Lawson,
    • F. George Otieno,
    • Erin Santa,
    • Julie L. Shaner,
    • Ryan M. Smith,
    • Robert Skraban,
    • Marcin Imielinski,
    • Rosetta M. Chiavacci,
    • Robert W. Grundmeier,
    • Charles A. Stanley,
    • Susan E. Kirsch,
    • Daryl Waggott,
    • Andrew D. Paterson,
    • Dimitri S. Monos,
    • the DCCT/EDIC Research Group,
    • Constantin Polychronakos,
    • and Hakon Hakonarson

    Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

    Diabetes January 2009 58:290-295; published ahead of print October 7, 2008, doi:10.2337/db08-1022
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This Issue

January 2009; 58 (1)
  1. Editorial
  2. Online Letters
  3. OSA Lecture 2008
  4. Commentaries
  5. New Methodologies and Databases
  6. Metabolism
  7. Signal Transduction
  8. Obesity Studies
  9. Original Article
    1. Obesity Studies
  11. Immunology and Transplantation
  12. Islet Studies
  13. Pathophysiology
  14. Complications
  15. Pharmacology & Therapeutics
  16. Genetics

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