Comment on: Barker et al. (2008) Two Single Nucleotide Polymorphisms Identify the Highest-Risk Diabetes HLA Genotype: Diabetes 57:3152–3155, 2008
- From the Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- Corresponding author: Cisca Wijmenga, c.wijmenga{at}medgen.umcg.nl
Barker et al. (1) recently proposed two single nucleotide polymorphisms (SNPs) to identify the highest HLA risk for type 1 diabetes. The SNP rs7454108, genotyped by TaqMan probes, tags the HLA haplotype DR4-DQA1*0301-DQB1*0302 (DR4-DQ8), whereas rs2040410, genotyped using PCR–restriction enzyme digestion, tags DR3-DQA1*0501-DQB1*0201 (DR3-DQ2.5). The initial role of HLA in type 1 diabetes was indicated by association with the HLA-DR3 and -DR4 antigens, but, more recently, the HLA-DQA1 and -DQB1 genes were shown to be …
