Response to Comment on: Klöting et al. (2008) Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth: Diabetes 57:2074–2082
- 1Institute for Genetics, Department of Mouse Genetics and Metabolism, University of Cologne and Center of Molecular Medicine Cologne, Cologne, Germany
- 2Department of Medicine, University of Leipzig, Leipzig, Germany
- Corresponding author: Matthias Blüher, bluma{at}medizin.uni-leipzig.de
We thank Bartke and Kopchick (1) for their interest in our study (2) and the important comment that elevated IGF-1 serum concentrations in mice with a conditional inactivation of the IGF-1 receptor in adipose tissue (IGF-1RaP2Cre mice) might be due to elevated growth hormone secretion despite the reported unaltered growth hormone levels in IGF-1RaP2Cre mice at the age of 24 weeks. Indeed, we …
