Table of Contents

Editorials

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- R. Paul Robertson
2009 Presidential Address: Mentoring … Touching the Future
Diabetes October 2009 58:2165-2167; doi:10.2337/db09-9029

Perspectives in Diabetes

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- Adrian Vella and
- Robert A. Rizza
Application of Isotopic Techniques Using Constant Specific Activity or Enrichment to the Study of Carbohydrate Metabolism
Diabetes October 2009 58:2168-2174; doi:10.2337/db09-0318
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- David M. Harlan,
- Norma Sue Kenyon,
- Olle Korsgren,
- Bart O. Roep,
- and for the Immunology of Diabetes Society
Current Advances and Travails in Islet Transplantation
Diabetes October 2009 58:2175-2184; doi:10.2337/db09-0476

Commentaries

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- Andreas Wiederkehr and
- Claes B. Wollheim
Linking Fatty Acid Stress to β-Cell Mitochondrial Dynamics
Diabetes October 2009 58:2185-2186; doi:10.2337/db09-0967
Select this article
- Norma S. Kenyon and
- Camillo Ricordi
Pretransplant Immune Parameters Associate With Islet Allograft Outcome: Implications for Transplant Strategy?
Diabetes October 2009 58:2187-2188; doi:10.2337/db09-1147

Original Article

Metabolism

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- Anne-Laure Colombani,
- Lionel Carneiro,
- Alexandre Benani,
- Anne Galinier,
- Tristan Jaillard,
- Thibaut Duparc,
- Géraldine Offer,
- Anne Lorsignol,
- Christophe Magnan,
- Louis Casteilla,
- Luc Pénicaud,
- and Corinne Leloup
Enhanced Hypothalamic Glucose Sensing in Obesity: Alteration of Redox Signaling
Diabetes October 2009 58:2189-2197; published ahead of print July 6, 2009, doi:10.2337/db09-0110
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- Erin E. Mulvihill,
- Emma M. Allister,
- Brian G. Sutherland,
- Dawn E. Telford,
- Cynthia G. Sawyez,
- Jane Y. Edwards,
- Janet M. Markle,
- Robert A. Hegele,
- and Murray W. Huff
Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance
Diabetes October 2009 58:2198-2210; published ahead of print July 10, 2009, doi:10.2337/db09-0634
Select this article
- Rachana Shah,
- Yun Lu,
- Christine C. Hinkle,
- Fiona C. McGillicuddy,
- Roy Kim,
- Sridhar Hannenhalli,
- Thomas P. Cappola,
- Sean Heffron,
- XingMei Wang,
- Nehal N. Mehta,
- Mary Putt,
- and Muredach P. Reilly
Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo
Diabetes October 2009 58:2211-2219; published ahead of print July 6, 2009, doi:10.2337/db09-0256
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- Bryan C. Bergman,
- Leigh Perreault,
- Devon M. Hunerdosse,
- Mary C. Koehler,
- Ali M. Samek,
- and Robert H. Eckel
Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking
Diabetes October 2009 58:2220-2227; published ahead of print July 6, 2009, doi:10.2337/db09-0481
Select this article
- Serge Summermatter,
- Helena Marcelino,
- Denis Arsenijevic,
- Antony Buchala,
- Olivier Aprikian,
- Françoise Assimacopoulos-Jeannet,
- Josiane Seydoux,
- Jean-Pierre Montani,
- Giovanni Solinas,
- and Abdul G. Dulloo
Adipose Tissue Plasticity During Catch-Up Fat Driven by Thrifty Metabolism: Relevance for Muscle-Adipose Glucose Redistribution During Catch-Up Growth
Diabetes October 2009 58:2228-2237; published ahead of print July 14, 2009, doi:10.2337/db08-1793

Signal Transduction

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- Silvia Gogg,
- Ulf Smith,
- and Per-Anders Jansson
Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes: The Role of Endothelin-1
Diabetes October 2009 58:2238-2245; published ahead of print July 6, 2009, doi:10.2337/db08-0961
Select this article
- Xiao-Nan Li,
- Jun Song,
- Lin Zhang,
- Scott A. LeMaire,
- Xiaoyang Hou,
- Cheng Zhang,
- Joseph S. Coselli,
- Li Chen,
- Xing Li Wang,
- Yun Zhang,
- and Ying H. Shen
Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
Diabetes October 2009 58:2246-2257; published ahead of print July 10, 2009, doi:10.2337/db08-1512

Obesity Studies

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- Alessandro Pocai,
- Paul E. Carrington,
- Jennifer R. Adams,
- Michael Wright,
- George Eiermann,
- Lan Zhu,
- Xiaobing Du,
- Aleksandr Petrov,
- Michael E. Lassman,
- Guoqiang Jiang,
- Franklin Liu,
- Corey Miller,
- Laurie M. Tota,
- Gaochao Zhou,
- Xiaoping Zhang,
- Michael M. Sountis,
- Alessia Santoprete,
- Elena Capito',
- Gary G. Chicchi,
- Nancy Thornberry,
- Elisabetta Bianchi,
- Antonello Pessi,
- Donald J. Marsh,
- and Ranabir SinhaRoy
Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
Diabetes October 2009 58:2258-2266; published ahead of print July 14, 2009, doi:10.2337/db09-0278

Immunology and Transplantation

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- Robert Hilbrands,
- Volkert A.L. Huurman,
- Pieter Gillard,
- Jurjen H.L. Velthuis,
- Marc De Waele,
- Chantal Mathieu,
- Leonard Kaufman,
- Miriam Pipeleers-Marichal,
- Zhidong Ling,
- Babak Movahedi,
- Daniel Jacobs-Tulleneers-Thevissen,
- Diethard Monbaliu,
- Dirk Ysebaert,
- Frans K. Gorus,
- Bart O. Roep,
- Daniel G. Pipeleers,
- and Bart Keymeulen
Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
Diabetes October 2009 58:2267-2276; doi:10.2337/db09-0160
Select this article
- Matthew J. Parker,
- Song Xue,
- John J. Alexander,
- Clive H. Wasserfall,
- Martha L. Campbell-Thompson,
- Manuela Battaglia,
- Silvia Gregori,
- Clayton E. Mathews,
- Sihong Song,
- Misty Troutt,
- Scott Eisenbeis,
- John Williams,
- Desmond A. Schatz,
- Michael J. Haller,
- and Mark A. Atkinson
Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice
Diabetes October 2009 58:2277-2284; published ahead of print July 23, 2009, doi:10.2337/db09-0557
Select this article
- Shoichiro Tanaka,
- Yoriko Nishida,
- Kaoru Aida,
- Taro Maruyama,
- Akira Shimada,
- Masako Suzuki,
- Hiroki Shimura,
- Soichi Takizawa,
- Masashi Takahashi,
- Daiichiro Akiyama,
- Sayaka Arai-Yamashita,
- Fumihiko Furuya,
- Akio Kawaguchi,
- Masahiro Kaneshige,
- Ryohei Katoh,
- Toyoshi Endo,
- and Tetsuro Kobayashi
Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit: A Mechanism of Accelerated β-Cell Failure in Fulminant Type 1 Diabetes
Diabetes October 2009 58:2285-2291; published ahead of print July 29, 2009, doi:10.2337/db09-0091

Islet Studies

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- Suhuan Liu,
- Cedric Le May,
- Winifred P.S. Wong,
- Robert D. Ward,
- Deborah J. Clegg,
- Marco Marcelli,
- Kenneth S. Korach,
- and Franck Mauvais-Jarvis
Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival
Diabetes October 2009 58:2292-2302; published ahead of print July 8, 2009, doi:10.2337/db09-0257
Select this article
- Anthony J.A. Molina,
- Jakob D. Wikstrom,
- Linsey Stiles,
- Guy Las,
- Hibo Mohamed,
- Alvaro Elorza,
- Gil Walzer,
- Gilad Twig,
- Steve Katz,
- Barbara E. Corkey,
- and Orian S. Shirihai
Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis
Diabetes October 2009 58:2303-2315; published ahead of print July 6, 2009, doi:10.2337/db07-1781
Select this article
- Emma M. Carrington,
- Mark D. McKenzie,
- Elisa Jansen,
- Michelle Myers,
- Stacey Fynch,
- Cameron Kos,
- Andreas Strasser,
- Thomas W. Kay,
- Clare L. Scott,
- and Janette Allison
Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli
Diabetes October 2009 58:2316-2323; published ahead of print July 6, 2009, doi:10.2337/db08-1602
Select this article
- Sandra Ueberberg,
- Juris J. Meier,
- Carmen Waengler,
- Wolfgang Schechinger,
- Johannes W. Dietrich,
- Andrea Tannapfel,
- Inge Schmitz,
- Ralf Schirrmacher,
- Manfred Köller,
- Harald H. Klein,
- and Stephan Schneider
Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo
Diabetes October 2009 58:2324-2334; published ahead of print July 10, 2009, doi:10.2337/db09-0658

Complications

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- Eelco van Duinkerken,
- Martin Klein,
- Niki S.M. Schoonenboom,
- Roel P.L.M. Hoogma,
- Annette C. Moll,
- Frank J. Snoek,
- Cornelis J. Stam,
- and Michaela Diamant
Functional Brain Connectivity and Neurocognitive Functioning in Patients With Long-Standing Type 1 Diabetes With and Without Microvascular Complications: A Magnetoencephalography Study
Diabetes October 2009 58:2335-2343; published ahead of print July 7, 2009, doi:10.2337/db09-0425
Select this article
- Jun Tanaka,
- Li Qiang,
- Alexander S. Banks,
- Carrie L. Welch,
- Michihiro Matsumoto,
- Tadahiro Kitamura,
- Yukari Ido-Kitamura,
- Ronald A. DePinho,
- and Domenico Accili
Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells
Diabetes October 2009 58:2344-2354; doi:10.2337/db09-0167
Select this article
- Prabhakara Reddy Nagareddy,
- Hesham Soliman,
- Guorong Lin,
- Padmesh S. Rajput,
- Ujendra Kumar,
- John H. McNeill,
- and Kathleen M. MacLeod
Selective Inhibition of Protein Kinase C β₂ Attenuates Inducible Nitric Oxide Synthase–Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats
Diabetes October 2009 58:2355-2364; published ahead of print July 8, 2009, doi:10.2337/db09-0432
Select this article
- Tatsuyo Nasu,
- Yohei Maeshima,
- Masaru Kinomura,
- Kumiko Hirokoshi-Kawahara,
- Katsuyuki Tanabe,
- Hitoshi Sugiyama,
- Hikaru Sonoda,
- Yasufumi Sato,
- and Hirofumi Makino
Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy
Diabetes October 2009 58:2365-2375; published ahead of print July 8, 2009, doi:10.2337/db08-1790
Select this article
- Andrea M. Vincent,
- John M. Hayes,
- Lisa L. McLean,
- Anuradha Vivekanandan-Giri,
- Subramaniam Pennathur,
- and Eva L. Feldman
Dyslipidemia-Induced Neuropathy in Mice: The Role of oxLDL/LOX-1
Diabetes October 2009 58:2376-2385; published ahead of print July 10, 2009, doi:10.2337/db09-0047
Select this article
- E. Shen,
- Yanwen Li,
- Ying Li,
- Limei Shan,
- Huaqing Zhu,
- Qingping Feng,
- J. Malcolm O. Arnold,
- and Tianqing Peng
Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia
Diabetes October 2009 58:2386-2395; published ahead of print July 10, 2009, doi:10.2337/db08-0617
Select this article
- Marina Cardellini,
- Rossella Menghini,
- Eugenio Martelli,
- Viviana Casagrande,
- Arianna Marino,
- Stefano Rizza,
- Ottavia Porzio,
- Alessandro Mauriello,
- Anna Solini,
- Arnaldo Ippoliti,
- Renato Lauro,
- Franco Folli,
- and Massimo Federici
TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
Diabetes October 2009 58:2396-2401; doi:10.2337/db09-0280

Genetics

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- Louise G. Grunnet,
- Emma Nilsson,
- Charlotte Ling,
- Torben Hansen,
- Oluf Pedersen,
- Leif Groop,
- Allan Vaag,
- and Pernille Poulsen
Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
Diabetes October 2009 58:2402-2408; published ahead of print July 8, 2009, doi:10.2337/db09-0205
Select this article
- Anna Jonsson,
- Bo Isomaa,
- Tiinamaija Tuomi,
- Jalal Taneera,
- Albert Salehi,
- Peter Nilsson,
- Leif Groop,
- and Valeriya Lyssenko
A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion
Diabetes October 2009 58:2409-2413; published ahead of print July 7, 2009, doi:10.2337/db09-0246
Select this article
- Jianhua Zhao,
- Mingyao Li,
- Jonathan P. Bradfield,
- Kai Wang,
- Haitao Zhang,
- Patrick Sleiman,
- Cecilia E. Kim,
- Kiran Annaiah,
- Wendy Glaberson,
- Joseph T. Glessner,
- F. George Otieno,
- Kelly A. Thomas,
- Maria Garris,
- Cuiping Hou,
- Edward C. Frackelton,
- Rosetta M. Chiavacci,
- Robert I. Berkowitz,
- Hakon Hakonarson,
- and Struan F.A. Grant
Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene
Diabetes October 2009 58:2414-2418; published ahead of print July 10, 2009, doi:10.2337/db09-0506
Select this article
- Kevin S.C. Hamming,
- Daniel Soliman,
- Laura C. Matemisz,
- Omid Niazi,
- Yiqiao Lang,
- Anna L. Gloyn,
- and Peter E. Light
Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K⁺ Channel
Diabetes October 2009 58:2419-2424; doi:10.2337/db09-0143

Errata

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Errata
Diabetes October 2009 58:2425; doi:10.2337/db09-er10a
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Errata
Diabetes October 2009 58:2425; doi:10.2337/db09-er10

Diabetes

Editorials

2009 Presidential Address: Mentoring … Touching the Future

Perspectives in Diabetes

Application of Isotopic Techniques Using Constant Specific Activity or Enrichment to the Study of Carbohydrate Metabolism

Current Advances and Travails in Islet Transplantation

Commentaries

Linking Fatty Acid Stress to β-Cell Mitochondrial Dynamics

Pretransplant Immune Parameters Associate With Islet Allograft Outcome: Implications for Transplant Strategy?

Original Article

Metabolism

Enhanced Hypothalamic Glucose Sensing in Obesity: Alteration of Redox Signaling

Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance

Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo

Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking

Adipose Tissue Plasticity During Catch-Up Fat Driven by Thrifty Metabolism: Relevance for Muscle-Adipose Glucose Redistribution During Catch-Up Growth

Signal Transduction

Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes: The Role of Endothelin-1

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

Obesity Studies

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

Immunology and Transplantation

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice

Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit: A Mechanism of Accelerated β-Cell Failure in Fulminant Type 1 Diabetes

Islet Studies

Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival

Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis

Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo

Complications

Functional Brain Connectivity and Neurocognitive Functioning in Patients With Long-Standing Type 1 Diabetes With and Without Microvascular Complications: A Magnetoencephalography Study

Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells

Selective Inhibition of Protein Kinase C β2 Attenuates Inducible Nitric Oxide Synthase–Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats

Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy

Dyslipidemia-Induced Neuropathy in Mice: The Role of oxLDL/LOX-1

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1

Genetics

Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion

Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel

Errata

Errata

Errata

This Issue

Current Issue

Selective Inhibition of Protein Kinase C β₂ Attenuates Inducible Nitric Oxide Synthase–Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K⁺ Channel