Table of Contents

Editorials

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- Peter C. Butler
Insulin Glargine Controversy: A Tribute to the Editorial Team at Diabetologia
Diabetes November 2009 58:2427-2428; doi:10.2337/db09-9030

Perspectives in Diabetes

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- James R. Bain,
- Robert D. Stevens,
- Brett R. Wenner,
- Olga Ilkayeva,
- Deborah M. Muoio,
- and Christopher B. Newgard
Metabolomics Applied to Diabetes Research: Moving From Information to Knowledge
Diabetes November 2009 58:2429-2443; doi:10.2337/db09-0580

Commentaries

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- Colin N.A. Palmer
Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies
Diabetes November 2009 58:2444-2447; doi:10.2337/db09-1153
Select this article
- Alain G. Bertoni and
- Dalane W. Kitzman
Coronary Artery Calcium: A Clue to the Enigma of Tight Glycemic Control and Cardiovascular Disease?
Diabetes November 2009 58:2448-2449; doi:10.2337/db09-1097

Original Article

New Methodologies and Databases

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- Andreas Schlotterer,
- Georgi Kukudov,
- Farastuk Bozorgmehr,
- Harald Hutter,
- Xueliang Du,
- Dimitrios Oikonomou,
- Youssef Ibrahim,
- Friederike Pfisterer,
- Naila Rabbani,
- Paul Thornalley,
- Ahmed Sayed,
- Thomas Fleming,
- Per Humpert,
- Vedat Schwenger,
- Martin Zeier,
- Andreas Hamann,
- David Stern,
- Michael Brownlee,
- Angelika Bierhaus,
- Peter Nawroth,
- and Michael Morcos
C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction
Diabetes November 2009 58:2450-2456; published ahead of print August 12, 2009, doi:10.2337/db09-0567

Obesity Studies

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- Jin Seo,
- Edgardo S. Fortuno III,
- Jae Myoung Suh,
- Drew Stenesen,
- Wei Tang,
- Elizabeth J. Parks,
- Christopher M. Adams,
- Tim Townes,
- and Jonathan M. Graff
Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
Diabetes November 2009 58:2565-2573; published ahead of print August 18, 2009, doi:10.2337/db09-0335
Select this article
- Shiho Fujisaka,
- Isao Usui,
- Agussalim Bukhari,
- Masashi Ikutani,
- Takeshi Oya,
- Yukiko Kanatani,
- Koichi Tsuneyama,
- Yoshinori Nagai,
- Kiyoshi Takatsu,
- Masaharu Urakaze,
- Masashi Kobayashi,
- and Kazuyuki Tobe
Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice
Diabetes November 2009 58:2574-2582; published ahead of print August 18, 2009, doi:10.2337/db08-1475
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- Iain T.H. Au-Yong,
- Natasha Thorn,
- Rakesh Ganatra,
- Alan C. Perkins,
- and Michael E. Symonds
Brown Adipose Tissue and Seasonal Variation in Humans
Diabetes November 2009 58:2583-2587; published ahead of print August 20, 2009, doi:10.2337/db09-0833

Immunology and Transplantation

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- Kevan C. Herold,
- Barbara Brooks-Worrell,
- Jerry Palmer,
- H. Michael Dosch,
- Mark Peakman,
- Peter Gottlieb,
- Helena Reijonen,
- Sefina Arif,
- Lisa M. Spain,
- Clinton Thompson,
- John M. Lachin,
- and the Type 1 Diabetes TrialNet Research Group
Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes
Diabetes November 2009 58:2588-2595; published ahead of print August 12, 2009, doi:10.2337/db09-0249

Islet Studies

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- Jiang-Yan Yang,
- Jöel Walicki,
- Evrim Jaccard,
- Gilles Dubuis,
- Natasa Bulat,
- Jean-Pierre Hornung,
- Bernard Thorens,
- and Christian Widmann
Expression of the NH₂-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes
Diabetes November 2009 58:2596-2606; published ahead of print August 20, 2009, doi:10.2337/db09-0104
Select this article
- Thierry Alquier,
- Marie-Line Peyot,
- Martin G. Latour,
- Melkam Kebede,
- Christina M. Sorensen,
- Stephane Gesta,
- C. Ronald Kahn,
- Richard D. Smith,
- Thomas L. Jetton,
- Thomas O. Metz,
- Marc Prentki,
- and Vincent Poitout
Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets
Diabetes November 2009 58:2607-2615; published ahead of print August 31, 2009, doi:10.2337/db09-0362

Pathophysiology

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- Konstantinos Kantartzis,
- Andreas Peter,
- Fausto Machicao,
- Jürgen Machann,
- Silvia Wagner,
- Ingmar Königsrainer,
- Alfred Königsrainer,
- Fritz Schick,
- Andreas Fritsche,
- Hans-Ulrich Häring,
- and Norbert Stefan
Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
Diabetes November 2009 58:2616-2623; published ahead of print August 3, 2009, doi:10.2337/db09-0279
Select this article
- Dongming Su,
- Gina M. Coudriet,
- Dae Hyun Kim,
- Yi Lu,
- German Perdomo,
- Shen Qu,
- Sandra Slusher,
- Hubert M. Tse,
- Jon Piganelli,
- Nick Giannoukakis,
- Jian Zhang,
- and H. Henry Dong
FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages
Diabetes November 2009 58:2624-2633; published ahead of print August 3, 2009, doi:10.2337/db09-0232
Select this article
- Scott M. Nelson,
- Philip M. Coan,
- Graham J. Burton,
- and Robert S. Lindsay
Placental Structure in Type 1 Diabetes: Relation to Fetal Insulin, Leptin, and IGF-I
Diabetes November 2009 58:2634-2641; published ahead of print August 18, 2009, doi:10.2337/db09-0739

Complications

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- Peter D. Reaven,
- Thomas E. Moritz,
- Dawn C. Schwenke,
- Robert J. Anderson,
- Michael Criqui,
- Robert Detrano,
- Nicholas Emanuele,
- Moti Kayshap,
- Jennifer Marks,
- Sunder Mudaliar,
- R. Harsha Rao,
- Jayendra H. Shah,
- Steven Goldman,
- Domenic J. Reda,
- Madeline McCarren,
- Carlos Abraira,
- and William Duckworth
Intensive Glucose-Lowering Therapy Reduces Cardiovascular Disease Events in Veterans Affairs Diabetes Trial Participants With Lower Calcified Coronary Atherosclerosis
Diabetes November 2009 58:2642-2648; published ahead of print August 3, 2009, doi:10.2337/db09-0618
Select this article
- Johan Wadén,
- Carol Forsblom,
- Lena M. Thorn,
- Daniel Gordin,
- Markku Saraheimo,
- and Per-Henrik Groop
A1C Variability Predicts Incident Cardiovascular Events, Microalbuminuria, and Overt Diabetic Nephropathy in Patients With Type 1 Diabetes
Diabetes November 2009 58:2649-2655; published ahead of print August 3, 2009, doi:10.2337/db09-0693
Select this article
- Janelle R. Latham,
- Sriyani Pathirathna,
- Miljen M. Jagodic,
- Won Joo Choe,
- Michaela E. Levin,
- Michael T. Nelson,
- Woo Yong Lee,
- Kathiresan Krishnan,
- Douglas F. Covey,
- Slobodan M. Todorovic,
- and Vesna Jevtovic-Todorovic
Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice
Diabetes November 2009 58:2656-2665; published ahead of print August 3, 2009, doi:10.2337/db08-1763
Select this article
- Cheol Whee Park,
- Hyung Wook Kim,
- Ji Hee Lim,
- Ki Dong Yoo,
- Sungjin Chung,
- Seok Joon Shin,
- Hyun Wha Chung,
- Sang Ju Lee,
- Chi-Bom Chae,
- Yong-Soo Kim,
- and Yoon Sik Chang
Vascular Endothelial Growth Factor Inhibition by dRK6 Causes Endothelial Apoptosis, Fibrosis, and Inflammation in the Heart via the Akt/eNOS Axis in db/db Mice
Diabetes November 2009 58:2666-2676; published ahead of print August 12, 2009, doi:10.2337/db09-0136
Select this article
- James F. McGuire,
- Shefali Rouen,
- Eric Siegfreid,
- Douglas E. Wright,
- and Rick T. Dobrowsky
Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy
Diabetes November 2009 58:2677-2686; published ahead of print August 12, 2009, doi:10.2337/db09-0594

Genetics

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- Amélie Bonnefond,
- Martine Vaxillaire,
- Yann Labrune,
- Cécile Lecoeur,
- Jean-Claude Chèvre,
- Nabila Bouatia-Naji,
- Stéphane Cauchi,
- Beverley Balkau,
- Michel Marre,
- Jean Tichet,
- Jean-Pierre Riveline,
- Samy Hadjadj,
- Yves Gallois,
- Sébastien Czernichow,
- Serge Hercberg,
- Marika Kaakinen,
- Susanne Wiesner,
- Guillaume Charpentier,
- Claire Lévy-Marchal,
- Paul Elliott,
- Marjo-Riitta Jarvelin,
- Fritz Horber,
- Christian Dina,
- Oluf Pedersen,
- Robert Sladek,
- David Meyre,
- and Philippe Froguel
Genetic Variant in HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits
Diabetes November 2009 58:2687-2697; published ahead of print August 3, 2009, doi:10.2337/db09-0652
Select this article
- Marcus G. Pezzolesi,
- Pisut Katavetin,
- Masahiko Kure,
- G. David Poznik,
- Jan Skupien,
- Josyf C. Mychaleckyj,
- Stephen S. Rich,
- James H. Warram,
- and Andrzej S. Krolewski
Confirmation of Genetic Associations at ELMO1 in the GoKinD Collection Supports Its Role as a Susceptibility Gene in Diabetic Nephropathy
Diabetes November 2009 58:2698-2702; published ahead of print August 3, 2009, doi:10.2337/db09-0641
Select this article
- John C. Chambers,
- Weihua Zhang,
- Delilah Zabaneh,
- Joban Sehmi,
- Piyush Jain,
- Mark I. McCarthy,
- Philippe Froguel,
- Aimo Ruokonen,
- David Balding,
- Marjo-Riitta Jarvelin,
- James Scott,
- Paul Elliott,
- and Jaspal S. Kooner
Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
Diabetes November 2009 58:2703-2708; published ahead of print August 3, 2009, doi:10.2337/db08-1805

Editorials

Insulin Glargine Controversy: A Tribute to the Editorial Team at Diabetologia

Perspectives in Diabetes

Metabolomics Applied to Diabetes Research: Moving From Information to Knowledge

Commentaries

Novel Insights Into the Etiology of Diabetes From Genome-Wide Association Studies

Coronary Artery Calcium: A Clue to the Enigma of Tight Glycemic Control and Cardiovascular Disease?

Original Article

New Methodologies and Databases

C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction

Metabolism

Muscle Contraction, but Not Insulin, Increases Microvascular Blood Volume in the Presence of Free Fatty Acid–Induced Insulin Resistance

Cleavage of Protein Kinase D After Acute Hypoinsulinemia Prevents Excessive Lipoprotein Lipase–Mediated Cardiac Triglyceride Accumulation

Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice

Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent: Potent Tissue-Specific Effects of Medium-Chain Fatty Acids

The microRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element–Binding Protein-1c/Myocyte Enhancer Factor 2C Pathway

Obesity Studies

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

Brown Adipose Tissue and Seasonal Variation in Humans

Immunology and Transplantation

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

Islet Studies

Expression of the NH2-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

Pathophysiology

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene

FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages

Placental Structure in Type 1 Diabetes: Relation to Fetal Insulin, Leptin, and IGF-I

Complications

Intensive Glucose-Lowering Therapy Reduces Cardiovascular Disease Events in Veterans Affairs Diabetes Trial Participants With Lower Calcified Coronary Atherosclerosis

A1C Variability Predicts Incident Cardiovascular Events, Microalbuminuria, and Overt Diabetic Nephropathy in Patients With Type 1 Diabetes

Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice

Vascular Endothelial Growth Factor Inhibition by dRK6 Causes Endothelial Apoptosis, Fibrosis, and Inflammation in the Heart via the Akt/eNOS Axis in db/db Mice

Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy

Genetics

Genetic Variant in HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits

Confirmation of Genetic Associations at ELMO1 in the GoKinD Collection Supports Its Role as a Susceptibility Gene in Diabetic Nephropathy

Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians

This Issue

Current Issue

Expression of the NH₂-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes