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C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction

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FIG. 4.
FIG. 4.

Mitochondrial MG-H1 immunoreactivity in C. elegans. Mitochondria were stained with MitoTracker Deep Red FM (A, D, G, and J), and MG-H1 was visualized by immunostaining with a Texas Red-labeled antibody directed against MG-H1 antibody (B, E, H, and K). Merged staining is shown in C, F, I, and L. Orange color indicates colocalization of MG-H1 with mitochondria. Images are shown for 15-day-old wild-type animals cultured under standard (AC) and high glucose conditions (DF) and 15-day-old transgenic glyoxalase-1–overexpressing animals cultured under standard (GI) and high glucose conditions (JL). Shown are animals from a representative experiment out of three independent experiments, each including 100 nematodes.

This Article

  1. Diabetes vol. 58 no. 11 2450-2456