Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent

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FIG. 3.
FIG. 3.

Immunoblots for markers of mitochondrial metabolism and biogenesis in skeletal muscle and liver from mice fed the low-fat (LF), MCFA, and LCFA diets. Equal amounts of muscle lysates (10–20 μg protein) were resolved by SDS-PAGE and immunoblotted with specific antibodies for PGC-1α, CPT-1, UCP3, and mitochondrial respiratory chain subunits. Densitometric analysis (relative to low-fat controls) for n = 6 animals is presented. *P < 0.05; †P < 0.01 vs. low fat; ‡P < 0.05; §P < 0.01 vs. MCFAs.

This Article

  1. Diabetes vol. 58 no. 11 2547-2554