Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent

TABLE 3

Body mass, fat pad mass, circulating parameters, and tissue triglyceride levels in rats

Low-fat diet MCFAs LCFAs
Body mass (g) 349 ± 7 337 ± 6 387 ± 5*
Epididymal fat (%) 1.0 ± 0.1 1.3 ± 0.1* 1.6 ± 0.05*
Retroperitoneal fat (%) 1.0 ± 0.1 1.3 ± 0.1 2.1 ± 0.2*
Lumbar fat (%) 1.5 ± 0.1 1.5 ± 0.1 2.2 ± 0.1*
Plasma glucose (mmol/l) 7.2 ± 0.2 7.5 ± 0.2 8.1 ± 0.2
Plasma insulin (mU/l) 24 ± 2 31 ± 3 66 ± 5*
Plasma triglycerides (mmol/l) 0.8 ± 0.1 0.9 ± 0.0 1.1 ± 0.2
Muscle triglycerides (μmol/g) 1.7 ± 0.1 1.9 ± 0.2 2.9 ± 0.3*
Liver triglycerides (μmol/g) 4.8 ± 0.3 18.4 ± 0.9* 14.4 ± 2.1*
  • Data are means ± SE for n = 5–9 animals. Fat pad weights are expressed as a percentage of body mass.

  • *P < 0.01 vs. low fat;

  • P < 0.01 vs. MCFAs;

  • P < 0.05 vs. low fat.

This Article

  1. Diabetes vol. 58 no. 11 2547-2554