Enhancement of Muscle Mitochondrial Oxidative Capacity and Alterations in Insulin Action Are Lipid Species Dependent

TABLE 4

Metabolic parameters from hyperinsulinemic-euglycemic clamps in rats

Low-fat diet MCFAs LCFAs
GIR (mg · kg−1 · min−1) 38.4 ± 1.6 31.4 ± 1.3* 21.5 ± 1.6*
Rd (mg · kg−1 · min−1) 36.9 ± 1.3 34.3 ± 1.1 25.9 ± 1.9*
HGO (mg · kg−1 · min−1) −1.5 ± 0.63 3.0 ± 1.1* 4.3 ± 0.4*
Rǵ (red quadriceps) 29.4 ± 2.0 26.5 ± 1.8 16.9 ± 2.7*
Rǵ (red gastrocnemius) 29.7 ± 2.8 26.8 ± 1.4 17.6 ± 0.8*
Rǵ (white gastrocnemius) 7.1 ± 0.6 9.0 ± 0.6* 5.4 ± 0.4*
Rǵ (epididymal fat) 1.8 ± 0.2 2.2 ± 0.2 1.0 ± 0.1*
  • Data are means ± SE for n = 5–7 animals. Plasma levels of glucose and insulin were similar for all groups during the clamp (data not shown).

  • *P < 0.01 vs. low fat;

  • P < 0.01 vs. MCFA. Rǵ, insulin-stimulated 3H-2-deoxyglucose uptake in skeletal muscle or adipose tissue during the clamp (μmol · 100 g−1 · min−1).

This Article

  1. Diabetes vol. 58 no. 11 2547-2554