Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice

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FIG. 2.
FIG. 2.

Ob/ob mice demonstrated significant mechanical (A) and thermal hypersensitivity (B) that coincided with morbid obesity and significant hyperglycemia (boxed area). A: Ob/ob mice had highly variable but significant mechanical hypersensitivity in both right (●) and left paws (○) (*P < 0.05) as compared with age-matched wild-type mice (right paws, ■; left paws, □). Peak mechanical hypersensitivity occurred from 8 to 16 weeks. B: When PWLs were measured, we found significant (*P < 0.001) decreases in both right (●) and left paws (○) of ob/ob mice as compared with age-matched controls. Although that peak decrease was detected from 8 to 16 weeks of age, PWL decreases remained significant as compared with those of wild-type mice throughout the age span. Similarly, there was a significant decrease in thermal PWLs in ob/ob mice from 6 weeks of age as compared with their PWLs at 4 weeks of age (†P < 0.001) (n = 12–18 ob/ob mice; n = 12–18 wild type mice). WT, wild type.

This Article

  1. Diabetes vol. 58 no. 11 2656-2665